Vinader, Victoria - University of Bradford - School of Medical Sciences

个人简介

PhD (Cum Laude) and BSc (First Class Hons) University of Murcia, Spain (1990) Fulbright Fellow, John Hopkins University, Baltimore, USA (1990-1992) Senior Investigator, GlaxoSmithKline, Medicinal Chemistry Department Stevenage, Hertfordshire (1992-2006)

研究领域

Synthetic organic synthesis Drug discovery and Medicinal Chemistry Modulation of chemokine signalling and its potential for anti-metastatic therapy Modulation of formylpeptide receptor signalling and identification of novel anticancer molecules with potential for inhibiting the migration and invasion of brain tumour cells, with a specific focus on the stem cell niche Modulation of metastatic pathways Computational chemistry and molecular modelling

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Study of the Chemotactic Response of Multicellular Spheroids in a Microfluidic Device. Jose M. Ayuso, Haneen A. Basheer, Rosa Monge, Pablo Sánchez-álvarez, Manuel Doblaré, Steven D. Shnyder, Victoria Vinader, Kamyar Afarinkia, Luis J. Fernández, Ignacio Ochoa. PLOS ONE published 07 Oct 2015. 10.1371/journal.pone.0139515 Probing Cytochrome P450-mediated activation with a truncat-ed azinomycin analogue. Victoria Vinader, Maria Sadiq, Mark Sutherland, Mengying Huang, Paul M. Loadman, Lina Elsalem, Steven D. Shnyder, Hongjuan Cui, Kamyar Afarinkia, Mark Searcey, Laurence H. Patterson, Klaus Pors. Med. Chem. Commun., 2015, 6, 187–191 Synthesis of a Pseudo-Disaccharide Library and Its Application to the Characterisation of the Heparanase Catalytic Site. Victoria Vinader, Mohamed H. Haji-Abdullahi, L. H. Patterson, Kamyar Afarinkia, PLOS ONE, published 18 Nov 2013. 10.1371/journal.pone.0082111 Discovery and Computer Aided Potency Optimization of a Novel Class of Small Molecule CXCR4 Antagonists. Victoria Vinader, Djevdet S. Ahmet, Mohaned S. Ahmed, Laurence H. Patterson, Kamyar Afarinkia, PLOS ONE, published 18 Oct 2013.| 10.1371/journal.pone.0078744 Carbasugar Probes to Explore the Enzyme Binding Pocket at the Anomeric Position: Application to the Design of Golgi Mannosidase II Inhibitors. V. Vinader, M.; Afarinkia, K. Current Medicinal Chemistry., 2013 20, (30), 3797-3801 Isolation and Characterisation of All Four Diastereomeric Intermediates From a Horner-Wittig Reaction. Parry, Laura J.; Vinader, Victoria; Scowen, Ian J.; Patel, Vipul K.; Afarinkia, Kamyar. Phosphorus, Sulfur and Silicon and the Related Elements. 2013, 188, 195-199 Synthesis and Biological Evaluation of Colchicine B-Ring Analogues Tethered with Halogenated Benzyl Moieties. Laura Cosentino , Mariano Redondo-Horcajo, Ying Zhao, Ana Rita Santos, Kaniz F. Chowdury ,Victoria Vinader, Qasem M. A. Abdallah , Hamdy Abdel-Rahman , Jérémie Fournier-Dit-Chabert ,Steven D. Shnyder , Paul M. Loadman , Wei-shuo Fang , José Fernando Díaz , Isabel Barasoain, Philip A. Burns, and Klaus Pors. Journal of Medicinal Chemistry. 2012, 55(24), 11062-11066 Synthesis and biological evaluation of colchicine C-ring analogues tethered with aliphatic linkers suitable for prodrug derivatisation Jérémie Fournier-Dit-Chabert, Victoria Vinader, Ana Rita Santos, Mariano Redondo-Horcajo, Aurore Dreneau, Ramkrishna Basak, Laura Cosentino, Gemma Marston, Hamdy Abdel-Rahman, Paul M. Loadman, Steven D. Shnyder, José Fernando Díaz, Isabel Barasoain, Robert A. Falconer, Klaus Pors . Bioorganic & Medicinal Chemistry Letters. 2012, 22(24), 7693-7696 An agarose spot chemotaxis assay for chemokine receptor antagonists. Vinader, V.; Al-Saraireh, Y.; Wiggins, H.L.; Rappoport, J.Z.; Shnyder, S.D.; Patterson, L.H.; Afarinkia, K. J. Pharmacol. Toxicol. Methods, 2011, 64, 213-216 Cycloadditions of chiral carbonyl ylides with imine dipolarophiles as a route to enantiomerically pure α-amino-?-hydroxy acids. Yu Gan, Laurence Harwood, Simon C. Richards, Ian E D Smith, Victoria Vinader. Tetrahedron Asymmetry. 2009, 20, 723-725 Enantioselective synthesis of tetrafluorinated ribose and fructose. Linclau, Bruno; Boydell, A. James; Timofte, Roxana S.; Brown, Kylie J.; Vinader, Victoria; Weymouth-Wilson, Alexander C. Organic & Biomolecular Chemistry. 2009, 7(4), 803-814 Oxazolidinones as novel human CCR8 antagonists. Jin J, Wang Y, Wang F, Kerns JK, Vinader VM, Hancock AP, Lindon MJ, Stevenson GI, Morrow DM, Rao P, Nguyen C, Barrett VJ, Browning C, Hartmann G, Andrew DP, Sarau HM, Foley JJ, Jurewicz AJ, Fornwald JA, Harker AJ, Moore ML, Rivero RA, Belmonte KE, Connor. Bioorganic & Medicinal Chemistry Letters. 2007, 17 (6), 1722-1725 Dissociated nonsteroidal glucocorticoid receptor modulators; Discovery of the agonist trigger in a tetrahydronaphthalene-benzoxazine series. Barker M.; Clackers, M.; Copley, R.; Demaine, D.A.; Humphreys, D.; Inglis, G.G.A.; Johnston, M.J.; Jones, H.T.; Haase, M.V.; House, D.; Loiseau, R.; Nisbet, L.; Pacquet, F.; Skone, P.A.; Shanahan, S.E.; Tape, D.; Vinader, V.M.; Washington, M.; Uings, I.; Upton, R.; Mclay, I.M.; Macdonald, S.J.F. Journal of Medicinal Chemistry 2006, 49 (14), 4216-4231 Conformational arm-wrestling: battles for stereochemical control in benzamides bearing matched and mismatched chiral 2- and 6-substituents. Clayden, J.; Foricher, Y.J.Y.; Helliwell, M.; Johnson, P.; Mitjans, D.; Vinader, V. Organic & Biomolecular Chemistry. 2006, 4 (3), 444-454 Design and Synthesis of New Nonsteroidal Glucocorticoid Modulators through application of an “Agreement Docking” method. Barker, M.; Clackers, M.; Demaine, D.A.; Humphreys, D.; Johnston, M.J.; Jones, H.T.; Pacquet, F.; Pritchard, J.M.; Salter, M.; Shanahan, S.E.; Skone, P.A.; Vinader, V.M.; Uings, I.; McLay, I.M.; Macdonald, S.J.F. Journal of Medicinal Chemistry. 2005, 48 (14), 4507-4510