Riches, Kirsten - University of Bradford - School of Medical Sciences

个人简介

2005-2008: PhD in Cardiovascular Medicine, University of Leeds 1999-2003: 1st class BSc (Hons) Biology (Molecular and Cellular), University of Huddersfield 2015-current: Lecturer in Biochemistry, University of Bradford 2008-2015: Post-doctoral Research Fellow (cardiovascular cell dysfunction in Type 2 diabetes and abdominal aortic aneurysm), University of Leeds 2004-2005: Research Technician, University of Bradford

研究领域

Diabetes, vascular biology, smooth muscle cells, endothelial cells, epigenetics

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Porter KE, Riches K. Vascular Smooth Muscle as a Target for Novel Therapeutics. Curr Diab Rep. 2015;15(10):72 Roberts AC, Gohil J, Hudson L, Connolly K, Warburton P, Suman R, O'Toole P, O'Regan DJ, Turner NA, Riches K, Porter KE. Aberrant phenotype in human endothelial cells of diabetic origin: implications for saphenous vein graft failure? J Diabetes Res. 2015;2015:409432 Riches K, Alshanwani AR, Warburton P, O'Regan DJ, Ball SG, Wood IC, Turner NA, Porter KE. Elevated expression levels of miR-143/5 in saphenous vein smooth muscle cells from patients with Type 2 diabetes drive persistent changes in phenotype and function. J Mol Cell Cardiol. 2014;74:240-50 Sedgwick B, Riches K, Bageghni SA, O'Regan DJ, Porter KE, Turner NA. Investigating inherent functional differences between human cardiac fibroblasts cultured from nondiabetic and Type 2 diabetic donors. Cardiovasc Pathol. 2014;23(4):204-10 Riches K, Warburton P, O'Regan DJ, Turner NA, Porter KE. Type 2 diabetes impairs venous, but not arterial smooth muscle cell function: possible role of differential RhoA activity. Cardiovasc Revasc Med. 2014;15(3):141-8 Riches K, Angelini TG, Mudhar GS, Kaye J, Clark E, Bailey MA, Sohrabi S, Korossis S, Walker PG, Scott DJ, Porter KE. Exploring smooth muscle phenotype and function in a bioreactor model of abdominal aortic aneurysm. J Transl Med. 2013;11:208 Riches K, Franklin L, Maqbool A, Peckham M, Adams M, Bond J, Warburton P, Feric NT, Koschinsky ML, O'Regan DJ, Ball SG, Turner NA, Porter KE. Apolipoprotein(a) acts as a chemorepellent to human vascular smooth muscle cells via integrin αVβ3 and RhoA/ROCK-mediated mechanisms. Int J Biochem Cell Biol. 2013;45(8):1776-83 Porter KE, Riches K. The vascular smooth muscle cell: a therapeutic target in Type 2 diabetes? Clin Sci (Lond). 2013;125(4):167-82 Riches K, Porter KE. Lipoprotein(a): Cellular effects and molecular mechanisms. Cholesterol. 2012; 2012:923289 Nintasen R, Riches K, Mughal RS, Viriyavejakul P, Chaisri U, Maneerat Y, Turner NA, Porter KE. Divergent effects of 17-β-estradiol on human vascular smooth muscle and endothelial cell function diminishes TNF-α-induced neointima formation. Biochem Biophys Res Commun. 2012;420(4):828-33 Cheong A, Li J, Sukumar P, Kumar B, Zeng F, Riches K, Munsch C, Wood IC, Porter KE, Beech DJ. Potent suppression of vascular smooth muscle cell migration and human neointimal hyperplasia by KV1.3 channel blockers. Cardiovasc Res. 2011;89(2):282-9 Riches K, Hettiarachchi NT, Porter KE, Peers C. Hypoxic remodelling of Ca2+ stores does not alter human cardiac myofibroblast invasion. Biochem Biophys Res Commun. 2010;403(3-4):468-72 Mughal RS, Scragg JL, Lister P, Warburton P, Riches K, O'Regan DJ, Ball SG, Turner NA, Porter KE. Cellular mechanisms by which proinsulin C-peptide prevents insulin-induced neointima formation in human saphenous vein. Diabetologia. 2010 Aug;53(8):1761-71 Bennett CE, Nsengimana J, Bostock JA, Cymbalista C, Futers TS, Knight BL, McCormack LJ, Prasad UK, Riches K, Rolton D, Scarrott T, Barrett JH, Carter AM. CCAAT/enhancer binding protein alpha, beta and delta gene variants: associations with obesity related phenotypes in the Leeds Family Study. Diab Vasc Dis Res. 2010;7(3):195-203 Al-Shawaf E, Naylor J, Taylor H, Riches K, Milligan CJ, O'Regan D, Porter KE, Li J, Beech DJ. Short-term stimulation of calcium-permeable transient receptor potential canonical 5-containing channels by oxidized phospholipids. Arterioscler Thromb Vasc Biol. 2010;30(7):1453-9 Madi HA, Riches K, Warburton P, O'Regan DJ, Turner NA, Porter KE. Inherent differences in morphology, proliferation, and migration in saphenous vein smooth muscle cells cultured from nondiabetic and Type 2 diabetic patients. Am J Physiol Cell Physiol. 2009;297(5):C1307-17 Maqbool A, Turner NA, Galloway S, Riches K, O'Regan DJ, Porter KE. The -1562C/T MMP-9 promoter polymorphism does not predict MMP-9 expression levels or invasive capacity in saphenous vein smooth muscle cells cultured from different patients. Atherosclerosis. 2009;207(2):458-65 Riches K, Morley ME, Turner NA, O'Regan DJ, Ball SG, Peers C, Porter KE. Chronic hypoxia inhibits MMP-2 activation and cellular invasion in human cardiac myofibroblasts. J Mol Cell Cardiol. 2009;47(3):391-9 Morley ME, Riches K, Peers C, Porter KE. Hypoxic inhibition of human cardiac fibroblast invasion and MMP-2 activation may impair adaptive myocardial remodelling. Biochem Soc Trans. 2007;35(5):905-7