Picksley, Steve - University of Bradford - School of Medical Sciences

个人简介

BSc (Hons) Biological Sciences - 2:1 , University of Leicester, 1981. PhD Genetics, University of Nottingham, 1985. PGCE in H.E., University of Bradford, 2001. FHEA, 2001.

研究领域

p53 tumour supressor, MDM2, p53-MDM2 inhibitors

近期论文

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K. Shorter, N.P. Farjo, S.M. Picksley & V.A. Randall (2008) Human hair follicles contain two forms of ATP-sensitive potassium channels, only one of which is sensitive to minoxidil. FASEB J. 22, 1725-1736. D.A. Dart, S.M. Picksley, P.A. Cooper, J.A. Double & M.C.Bibby. (2004) The role of p53 in chemotherapeutic responses to cisplatin, doxorubicin and 5-fluorouracil treatment. Int. J. Oncology 24, 115-125. K.U. Schallreuter, Behrens-Williams, S.C., Khaliq, T.P., Picksley, S.M., Peters, E., Marles, L.K., Westerhof, W., Miehe, B. & Fanghanel, J. (2003) Increased epidermal functioning wild type p53 expression in vitiligo. Exp. Dermatology. 12,268-277. K. Krzewski, D. Kunikowska,, J. Wysocki, A. Kotlarz, P. Thompkins, W. Ashraf, N. Lindsey, S. Picksley, R. Glosnicka & B. Lipinski (2003) Characterization of the anti-DnaJ monoclonal antibodies and their use to compare immunological properties of DnaJ and its human homolog HDJ-1. Cell Stress & Chaperones 8, 8-17. S.M. Picksley, D.A. Dart, M.S. Mansoor & P.M. Loadman. (2001) Current advances in the inhibition of the autoregulatory interaction between the p53 tumour suppressor and MDM2 protein. Expert Opin. Ther. Patents 11:1825-1835. P.J. Coates, R. Nenutil, A. MacGregor, S.M. Picksley, D.H. Crouch, P.A. Hall & E.G. Wright. (2001) Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence. Experimental Cell Research 265, 262-273. M.E. Lomax, D.M. Barnes, T.R. Hupp, S.M. Picksley & R.S. Camplejohn. (1998) Characterization of p53 oligomerisation domain mutations isolated from p53 in a Li-Fraumeni and Li-Fraumeni like family members. Oncogene 17:643-9 A. Bottger, V. Bottger, C. Garcia-Echeveria, P. Chene, C. Garcia-Echeveria, P. Chene, H-K. Hochkeppel, S.F. Howard S.M. Picksley& D.P. Lane. (1997) Molecular characterization of the hdm2-p53 interaction. J. Mol. Biol. 269,744-756. M.E. Lomax, D.M. Barnes, R. Gilchrist, S.M. Picksley, J.M. Varley & R.S. Camplejohn. (1997) Two functional assays employed to detect an unusual mutation in the oligomerisation domain of p53 in a Li-Fraumeni like family. Oncogene. 14,1869-1874. V. Bottger, A. Bottger, S.F. Howard, S.M. Picksley, P. Chene, C. Garcia-Echeverria, H-K. Hochkeppel & D.P. Lane. (1996). Identification of novel MDM2 binding peptides by phage display. Oncogene 13:2141-2147. S.M. Picksley, J.F. Spicer, D.M. Barnes & D.P. Lane. (1996) The p53-MDM2 interaction in a cancer-prone family, and identification of a novel therapeutic target. Acta Oncologica 35:429-434. S.P. Dowell, E. McGoogan, S.M. Picksley, W. El-Deiry, B. Vogelstein & P.A. Hall. Expression of p21, WAF1/CIP1, MDM2 and p53 in vivo: analysis of cytological specimens. (1996) Cytopathology 7:340-351. D.P. Lane, C.W. Stephen, C.A. Midgley, A. Sparks, A. Reid, T. R. Hupp, D.A. Daniels, R. Greaves, A. Reid, B. Vojtesek & S.M. Picksley. (1996) Epitope analysis of the murine p53 tumour suppressor protein. Oncogene 12:2461-2466. S.A. Belinsky, S.K. Middleton, S.M. Picksley, F.F. Hahn & Nikula. K.J. (1996) Alterations in the K-Ras and p53 pathways in X-ray induced lung tumours in the rat. Radiation Research 145:449-456. Z. Lucas, B. Vojtesek, M. Anton, S.M. Picksley & V. Kubalek (1995) Overexpression of p53 and MDM2 proteins in cervical neoplasia. Folia Biologica 41:197-199. D.P. Lane, C.A. Midgley, T.R. Hupp, X. Lu, B. Vojtesek & S.M. Picksley. (1995) On the regulation of the p53 tumour supressor, and its role in the cellular response to DNA damage. Phil. Trans. Royal. Soc. Series B, 347:83-87. S.M. Picksley & D.P. Lane. (1994) p53 and Rb their cellular roles. Curr. Opin. in Cell. Biol. 6:853-858. S.M. Picksley,B. Vojtesek, A. Sparks & D.P. Lane. (1994) Immunochemical analysis of the interaction of p53 with MDM2; - fine mapping of the MDM2 binding site on p53 using synthetic peptides. Oncogene 9:2523-2529. E.S. Hickman, S.M. Picksley& K.H. Vousden. (1994) Cells expressing HPV16 E7 continue cell cycle progression following DNA damage induced p53 activation. Oncogene 9:2177-2182.