个人简介

Chuvash State University, Russia (MD, 1982) People's Friendship University, Russia (PhD, 1988)

研究领域

Skin is a complex organ which establishes interface between the external environment and internal milieu and provides conditions for survival and comfortable life. The research program of our laboratory is focused on the systems analysis of the molecular mechanisms that control the development and regeneration of the skin and its appendages (hair follicles, sweat glands, mammary glands, etc.). Major signalling pathways that control skin development are also implicated in skin carcinogenesis, and we are interested in further understanding mechanisms that govern normal versus neoplastic cell fate decision in the epidermis, hair follicle and mammary gland. We are also focused on delineating mechanisms that underlie the cutaneous responses to cancer treatment including chemotherapy-associated hair loss.

Systems biology of the mammalian integument, Development and regeneration of the skin and its appendages, Molecular mechanisms controlling normal versus neoplastic keratinocyte differentiation and skin carcinogenesis, Mechanisms of the cutaneous response to chemotherapy

近期论文

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Mardaryev AN, Gdula MR, Yarker JL, Emelianov VN, Poterlowicz K, Sharov AA, Sharova TY, Scarpa JA, Chambon P, Botchkarev VA, Fessing MY.p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells.Development. 2014 Jan;141(1):101-11. doi: 10.1242/dev.103200. http://www.ncbi.nlm.nih.gov/pubmed/24346698 Botchkarev VA, Fessing MY, Botchkareva NV, Westgate G, Tobin DJ.First international symposium "epigenetic control of skin development and regeneration": how chromatin regulators orchestrate skin functions.J Invest Dermatol. 2013 Aug;133(8):1918-21. doi: 10.1038/jid.2013.126. http://www.ncbi.nlm.nih.gov/pubmed/23856928 Gdula MR, Poterlowicz K, Mardaryev AN, Sharov AA, Peng Y, Fessing MY, Botchkarev VA.Remodeling of Three-Dimensional Organization of the Nucleus during Terminal Keratinocyte Differentiation in the Epidermis.J Invest Dermatol. 2013 Feb 13. doi: 10.1038/jid.2013.66. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/23407401 Paus R, Haslam IS, Sharov AA, Botchkarev VA.Pathobiology of chemotherapy-induced hair loss.Lancet Oncol. 2013 Feb;14(2):e50-9. doi: 10.1016/S1470-2045(12)70553-3. Review. http://www.ncbi.nlm.nih.gov/pubmed/23369683 Liu B, Liu YF, Du YR, Mardaryev AN, Yang W, Chen H, Xu ZM, Xu CQ, Zhang XR,Botchkarev VA, Zhang Y, Xu GL.Cbx4 regulates the proliferation of thymic epithelial cells and thymus function.Development. 2013 Feb;140(4):780-8. doi: 10.1242/dev.085035. http://www.ncbi.nlm.nih.gov/pubmed/23362346 Kohwi-Shigematsu T, Poterlowicz K, Ordinario E, Han HJ, Botchkarev VA, Kohwi Y.Genome organizing function of SATB1 in tumor progression.Semin Cancer Biol. 2013 Apr;23(2):72-9. doi: 10.1016/j.semcancer.2012.06.009. Epub 2012 Jul 4. http://www.ncbi.nlm.nih.gov/pubmed/22771615 Botchkarev VA, Gdula MR, Mardaryev AN, Sharov AA, Fessing MY.Epigenetic Regulation of Gene Expression in Keratinocytes.J Invest Dermatol. 2012 Jul 5. doi: 10.1038/jid.2012.182. http://www.ncbi.nlm.nih.gov/pubmed/22763788 Mardaryev AN, Meier N, Poterlowicz K, Sharov AA, Sharova TY, Ahmed MI, Rapisarda V, Lewis C, Fessing MY, Ruenger TM, Bhawan J, Werner S, Paus R, Botchkarev VA.Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury.Development. 2011 Nov;138(22):4843-52. http://www.ncbi.nlm.nih.gov/pubmed/22028024 Fessing MY, Mardaryev AN, Gdula MR, Sharov AA, Sharova TY, Rapisarda V, Gordon KB, Smorodchenko AD, Poterlowicz K, Ferone G, Kohwi Y, Missero C, Kohwi-Shigematsu T, Botchkarev VA.p63 regulates Satb1 to control tissue-specific chromatin remodelling during development of the epidermis. J Cell Biol.2011 Sep 19;194(6):825-39. http://www.ncbi.nlm.nih.gov/pubmed/21930775 Ahmed MI, Mardaryev AN, Lewis CJ, Sharov AA, Botchkareva NV.MicroRNA-21 is an important downstream component of BMP signalling in epidermal keratinocytes.J Cell Sci. 2011 Oct 15; 124(Pt 20):3399-404. http://www.ncbi.nlm.nih.gov/pubmed/21984808 Peters EM, Liezmann C, Spatz K, Daniltchenko M, Joachim R, Gimenez-Rivera A, Hendrix S, Botchkarev VA, Brandner JM, Klapp BF.Nerve growth factor partially recovers inflamed skin from stress-induced worsening in allergic inflammation.J Invest Dermatol. 2011 Mar;131(3):735-43. http://www.ncbi.nlm.nih.gov/pubmed/21085186 Sharov AA, Schroeder M, Sharova TY, Mardaryev AN, Peters EM, Tobin DJ, Botchkarev VA.Matrix Metalloproteinase-9 Is Involved in the Regulation of Hair Canal Formation.J Invest Dermatol. 2010 Sep 30. [Epub ahead of print] No abstract available. Mardaryev AN, Ahmed MI, Vlahov NV, Fessing MY, Gill JH, Sharov AA,Botchkareva NV.Micro-RNA-31 controls hair cycle-associated changes in gene expression programs of the skin and hair follicle. FASEB J. 2010 Oct;24(10):3869-81 http://www.ncbi.nlm.nih.gov/pubmed/20522784 Lyubimova A, Garber JJ, Upadhyay G, Sharov A, Anastasoaie F, Yajnik V, Cotsarelis G, Dotto GP, Botchkarev V, Snapper SB.Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice.J Clin Invest. 2010 Feb 1;120(2):446-56. doi: 10.1172/JCI36478. Epub 2010 Jan 11. http://www.ncbi.nlm.nih.gov/pubmed/20071778 Fessing MY, Atoyan R, Shander B, Mardaryev AN, Botchkarev VV Jr, Poterlowicz K, Peng Y, Efimova T, Botchkarev VA.BMP signaling induces cell-type-specific changes in gene expression programs of human keratinocytes and fibroblasts.J Invest Dermatol. 2010 Feb;130(2):398-404. Epub 2009 Aug 27. http://www.ncbi.nlm.nih.gov/pubmed/19710687 Sharov AA, Mardaryev AN, Sharova TY, Grachtchouk M, Atoyan R, Byers HR, Seykora JT, Overbeek P, Dlugosz A, Botchkarev VA.Bone morphogenetic protein antagonist noggin promotes skin tumorigenesis via stimulation of the Wnt and Shh signaling pathways.Am J Pathol. 2009 Sep;175(3):1303-14. Epub 2009 Aug 21. http://www.ncbi.nlm.nih.gov/pubmed/19700758 Atoyan RY, Sharov AA, Eller MS, Sargsyan A, Botchkarev VA, Gilchrest BA.Oligonucleotide treatment increases eumelanogenesis, hair pigmentation and melanocortin-1 receptor expression in the hair follicle.Exp Dermatol. 2007 Aug;16(8):671-7. http://www.ncbi.nlm.nih.gov/pubmed/17620094 Siebenhaar F, Sharov AA, Peters EM, Sharova TY, Syska W, Mardaryev AN, Freyschmidt-Paul P, Sundberg JP, Maurer M, Botchkarev VA.Substance P as an immunomodulatory neuropeptide in a mouse model for autoimmune hair loss (alopecia areata).J Invest Dermatol. 2007 Jun;127(6):1489-97. Epub 2007 Feb 1. http://www.ncbi.nlm.nih.gov/pubmed/17273166 Fessing MY, Sharova TY, Sharov AA, Atoyan R, Botchkarev VA.Involvement of the Edar signaling in the control of hair follicle involution (catagen).Am J Pathol. 2006 Dec;169(6):2075-84.http://www.ncbi.nlm.nih.gov/pubmed/17148670