Afarinkia, Kamyar - University of Bradford - School of Medical Sciences

个人简介

PhD & Diploma of Imperial College (London), BSc (Hons) & Associateship of the Royal College of Science, London.

研究领域

Drug Discovery and Medicinal Chemistry; Modulation of chemotactic signalling and its potential for cancer therapy; Inhibitors of glycosyl hydrolases (e.g. heparanase, golgi mannosidase II); Synthetic Organic Chemistry Diels-Alder cycloadditions of 2(H)-pyrones, 2(H)-pyridones and 2(H)-1,4-oxazin-2-ones; Asymmetric synthesis using chiral phosphorus; Total synthesis of biologically interesting and structurally unusual natural products; Peptide turn mimetics

近期论文

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Ayuso, J. M.; Basheer, H. A.; Monge, R.; Sánchez-álvarez, P.; Doblaré, M.; Shnyder, S. D.; Vinader, V.; Afarinkia, K.; Fernández, L. J.; Ignacio Ochoa “Study of the chemotactic responses of multicellular spheroids in a microfluidic device” PLoS ONE, 10(10), e0139515, (2015) Vinader, V.; Sadiq, M.; Sutherland, M.; Huang, M.; Loadman, P. M.; Elsalem L.; Shnyder, S. D.; Cui, H.; Afarinkia, K.; Searcey, M.; Patterson, L. H.; Pors, K “Probing cytochrome P450-mediated activation with a truncated azinomycin analogue” Medicinal Chemistry Communications, 6, 187-191, (2015) Vinader, V.; Haji Abdullahi, M.; Patterson L.H.; Afarinkia, K. “Synthesis of a Pseudo-Disaccharide Library and its Application to the Characterisation of the Heparanase Catalytic Site” PLoS ONE, 8(11), e82111, (2013) Vinader, V.; Ahmet, D.S.; Ahmed M.S.; Patterson L.H.; Afarinkia, K. “Discovery and Computer Aided Potency Optimization of a Novel Class of Small Molecule CXCR4 Antagonists” PLoS ONE, 8(10), e78744, (2013) Vinader, V.; Afarinkia, K. “Carbasugar Probes to Explore the Enzyme Binding Pocket at the Anomeric Position: Application to the Design of Golgi Mannosidase II Inhibitors” Current Medicinal Chemistry, 20, 3797-3801. (2013) Parry, L.J.; Vinader, V.; Scowen I. J., Patel, V. K.; Afarinkia, K. “Isolation and Characterisation of all Four Diastereomeric Intermediates from a Horner-Wittig Reaction” Phosphorus Sulfur and Silicon and the Related Elements 188(1-3), 195-199 (2013)