个人简介

2014 CETL Hesberg Award for Teaching Fellow (Georgia Tech); 2014 CETL Faculty Award for Academic Outreach (Georgia Tech); 2013 Sigma Xi Young Faculty Award (Georgia Tech); 2012 NOBCChE Lloyd N. Ferguson Young Scientist Award; 2012 Blanchard Assistant Professorship (Georgia Tech School of Chemistry and Biochemistry);2011 NSF CAREER Award; 2009 ORAU Ralph E. Powe Junior Faculty Enhancement Award; 2009 Georgia Tech Thank A Teacher Program Award; 2008 Georgia Tech Thank A Teacher Program Award; 2008 Carl Storm Minority Fellowship, Stereochemistry Gordon Research Conference; 2007 NSF FACES Career Initiation Grant; 2005 NIH Postdoctoral Research Supplement to Promote Diversity; 2004 Ford Foundation Dissertation Fellowship; 2004 NOBCChE/GlaxoSmithKline Lendon Pridgen Dissertation Fellowship; 2002 Johns Hopkins University Chambers Fellowship; 2002 United Negro College Fund/Merck Science Initiative Dissertation Fellowship; 2002 Pfizer Diversity Fellowship

研究领域

Catalysis/Chemical Evolution/Medicinal Chemistry/Organic Chemistry/Synthesis

Method Development. Our group is interested in the design of efficient methodologies to accomplish the formation of carbon-carbon and carbon-heteroatom bonds with the intent to apply the methodology toward the synthesis of complex natural and unnatural targets. Natural Product Synthesis. Approaches to natural products not only inspire the development of new synthetic strategies, but often unveil unexpected and often interesting reactivity. Targets are chosen for their interesting biological activity along with their sheer complexity. We are interested in exploring both modular and convergent approaches to complex targets that enable facile derivatization for the development of combinatorial libraries. Medicinal Chemistry. Medicinal or pharmaceutical chemistry lies at the intersection of chemistry and pharmacy. Our group is interested in the design, synthesis and development of pharmaceutical drugs, or other chemical entities suitable for therapeutic use. We are further interested in the study of their biological properties and their quantitative structure-activity relationships (QSAR). Given that medicinal chemistry is a highly interdisciplinary science, we aim to establish several collaborations with biologists, biochemists, and computational chemists to facilitate the design and development process. In particular, we aim to develop therapeutics toward the treatment of various forms of cancer, HIV, diabetes, and neurological disorders, such as Alzheimer's and Parkinson's disease.

近期论文

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Raynold Shenje, Corey W. Williams, Katherine M. Francois, and Stefan France*. Catalysis and Chemodivergence in the Interrupted, Formal Homo-Nazarov Cyclization Using Allylsilanes. Organic Letters, 2014, 16, 6468. Raynold Shenje, M. Cynthia Martin, and Stefan France*. A Catalytic, Diastereoselective Formal [5+2] Cycloaddition Approach to Azepino[1,2-a]indoles: Putative Donor-Acceptor Cyclobutanes as Reactive Intermediates. Angewandte Chemie International Edition, 2014, 53, 13907. Joel Aponte-Guzmán, J. Evans Taylor, Jr., Elayna Tillman, and Stefan France*. Catalytic, Formal Homo-Nazarov-type Cyclizations of Alkylidene Cyclopropane-1,1-Diesters: Access to Functionalized Arenes and Heteroaromatics. Organic Letters 2014, 16, 3788. M. Cynthia Martin, Dadasaheb V. Patil, and Stefan France.* Functionalizaed 4-Carboxy- and 4-Keto-2,3-dihydropyrroles via Ni(II)-Catalyzed Nucleophilic Amine Ring-Opening Cyclizations of Cyclopropanes. Journal of Organic Chemistry, 2014, 79, 3030. Susan Orwig, Pamela Chi, Yuhong Du, Shannon Hill, Marchello Cavitt, Amirthaa Suntharalingam, Katherine Turnage, Chad A. Dickey, Stefan France, Haian Fu, and Raquel Lieberman. Ligands for Glaucoma-Associated Myocilin Discovered by a Generic Binding Assay. ACS Chemical Biology, 2014, 9, 517. Marchello A. Cavitt, Lien H. Phun, and Stefan France.* Intramolecular Donor-Acceptor Ring-Opening Cyclizations. Chemical Society Reviews, 2014, in press. Lien H. Phun, Joel Aponte-Guzman, and Stefan France.* Acid-Catalyzed Ring-Opening Isomerizations of Cyclopropenes. Synlett 2012, 23, 2723. Dadasaheb V. Patil, Marchello A. Cavitt, Paul Grzybowski, and Stefan France.* A General Intramolecular Friedel-Crafts approach to functionalized pyrrolo[3,2,1-ij]quinolin-4-ones. Chemical Communications, 2012, 48, 10337. Pramod Warrier, Aravind Sathyanarayana, Dadasaheb V. Patil, Stefan France, Yogendra Joshi,* and Amyn Teja. Novel Heat Transfer Fluids for Direct Immersion Phase Change Cooling of Electronic Systems. International Journal of Heat and Mass Transfer, 2012, 55, 3379. Lien H. Phun, Joel Aponte-Guzman, and Stefan France.* In-Catalyzed Cycloisomerization of Cyclopropene-3,3-Dicarbonyl Compounds: Efficient Access to Benzo-fused Heteroaromatics and Heterobiaryls. Angewandte Chemie International Edition, 2012, 51, 3198. Dadasaheb V. Patil, Marchello A. Cavitt, and Stefan France.* Diastereoselective Synthesis of (+/-)-Deethyleburnamonine Using a Catalytic Cyclopropane Ring-Opening/Friedel-Crafts Alkylation Strategy. Heterocycles 2012, 84, 1363. Dadasaheb V. Patil, Marchello A. Cavitt, and Stefan France.* Diastereoselective Intramolecular Friedel-Crafts Cyclizations of Substituted Methyl 2-(1H-indole-carbonyl)acrylates: Efficient Access to Functionalized 1H-pyrrolo[1,2-a]indoles. Organic Letters, 2011, 13, 5820. Kunyun He, Chi-Bun Chan, Xia Liu, Yonghui Jia, Hongbo R. Luo, Stefan A. France, Yang Liu, W. David Wilson, and Keqiang Ye*. Identification of a Molecular Activator for Insulin Receptor with Potent Anti-Diabetic Effects. Journal of Biological Chemistry, 2011, 286, 37379. Dadasaheb V. Patil, Marchello A. Cavitt, Paul Grzybowski, and Stefan France.* An efficient synthesis of hydropyrido[1,2-a]indole-6(7H)-ones via an In(III)-catalyzed tandem cyclopropane ring-opening/Friedel-Crafts alkylation sequence. Chemical Communications 2011, 47, 10278.. E. Paige Stout, Serena Cervantes, Jacques Prudhomme, Stefan France, James J. LaClair, Karine LeRoch, and Julia Kubanek*. Bromophycolide A Targets Heme Crystallization in the Human Malaria Parasite Plasmodium falciparum. ChemMedChem 2011, 6, 1572. Lien H. Phun, Dadasaheb V. Patil, Marchello A. Cavitt, and Stefan France.* A Catalytic Homo-Nazarov Protocol for the Synthesis of Heteroaromatic Ring-Fused Cyclohexanones. Organic Letters 2011, 13, 1952. Dadasaheb V. Patil, Lien H. Phun, and Stefan France.* Indium Triflate-Catalyzed Homo-Nazarov Cyclizations of Alkenyl Cyclopropyl Ketones. Organic Letters 2010, 12, 5684. Xia Liu, Chi-Bun Chan, Sompol Pradoldej, Sung-Wuk Jang, Lien H. Phun, Stefan France, Ge Xiao, Yonghui Jia, Hongbo R. Luo, and Keqiang Ye.* A Synthetic 7,8-Dihydroxyflavone Derivative Promotes Neurogenesis and Exhibits Potent Antidepressant Effect. Journal of Medicinal Chemistry 2010, 53, 8274. Sung-Wuk Jang, Xia Liu, Chi-Bun Chan, Stefan A. France, Iqbal Sayeed, DonaldStein, Wenxue Tang, Xi Lin, Ge Xiao, Raul Andero, Qiang Chang, Kerry J. Ressler, and Keqiang Ye*. Deoxygedunin, a Natural Product with Potent Neurotrophic Activity in Mice. PLoS One 2010, 5, e11528.