个人简介

I completed my BSc (Hons) and PhD in Chemistry at the University of Bristol. My PhD (1995) was supervised by Professor Tom Simpson where I completed the first NMR structure of a protein (actinorhodin ACP) using 500 and 600 MHz homonuclear NNR spectra (never ever again). Actually I did then go on to this again at the University of Alberta, Canada where I completed post-doctoral studies with Professor brian Sykes. During my three years in Canada we solved numerous NMR structures of chemokines, coiled coils, peptides and bacterial surface proteins. In 1999 I established a 600 MHz biological NMR centre in the School of Biological Sciences in Southampton followed by a new biological NMR centre at Bristol in 2003. This facility has grown to encompass two 600 MHz spectrometers as well as associated low field spectrometers as part of the chemistry NMR facility (under Dr Craig Butts). My group works on a range of structural biology problems and to date has deposited over 30 novel protein structures

研究领域

Protein Structure and Function using Biological NMR

My group's work has centred around the use of nuclear magnetic resonance spectroscopy to study protein structure and function. The most high profile of these are based in areas such as cancer, antibiotics and structure aided drug design that are of central importance to the well being of today's society.

近期论文

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Dong, X, Bailey, C, Williams, C, Crosby, J, Simpson, T, Willis, C & Crump, M, 2015, ‘Recognition of extended linear and cyclised polyketide mimics by a Type II acyl carrier protein’. Chemical Science, vol 7., pp. 1779-1785 Shoemark, DK, Williams, C, Fahey, MS, Watson, JJ, Tyler, SJ, Scoltock, SJ, Ellis, R, Wickendon, E, Burton, AJ, Hemmings, JLL, Bailey, CD, Dawbarn, D, Jane, DE, Willis, CL, Sessions, RB, Allen, SJ & Crump, MP, 2015, ‘Design and nuclear magnetic resonance (NMR) structure determination of the second extracellular immunoglobulin tyrosine kinase A (TrkAIg2) domain construct for binding site elucidation in drug discovery’. Journal of Medicinal Chemistry, vol 58., pp. 767-777 Carter, T, Mooibroek, T, Stewart, P, Crump, M, Galan, C & Davis, A, 2016, ‘Platform Synthetic Lectins for Divalent Carbohydrate Recognition in Water’. Angewandte Chemie International Edition, vol 55., pp. 9311?9315 Frago, S, Nicholls, R, Strickland, M, Hughes, J, Williams, C, Garner, L, Surakhy, M, Maclean, R, Rezgui, DAR, Prince, S, Zaccheo, O, Ebner, D, Sanegre, S, Yu, S, Buffa, FM, Crump, M & Hassan, AB, 2016, ‘Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist’. Proceedings of the National Academy of Sciences of the United States of America, vol 113., pp. E2765-E2775 Mooibroek, TJ, Crump, MP & Davis, A, 2016, ‘Synthesis and evaluation of a desymmetrised synthetic lectin: An approach to carbohydrate receptors with improved versatility’. Organic & Biomolecular Chemistry, vol 14., pp. 1930-1933 Wattana-Amorn, P, Charoenwongsa, W, Williams, C, Crump, MP & Apichaisataienchote, B, 2015, ‘Antibacterial activity of cyclo(L-Pro-L-Tyr) and cyclo(D-Pro-L-Tyr) from Streptomyces sp. strain 22-4 against phytopathogenic bacteria’. Natural Product Reports. Butt, A, Higman, VA, Williams, C, Crump, MP, Hemsley, CM, Harmer, N & Titball, RW, 2014, ‘The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation’. Biochemical Journal. Haines, AS, Dong, X, Song, Z, Farmer, R, Williams, C, Hothersall, J, Ploskon, E, Wattana-amorn, P, Stephens, ER, Yamada, E, Gurney, R, Takebayashi, Y, Masschelein, J, Cox, RJ, Lavigne, R, Willis, CL, Simpson, TJ, Crosby, J, Winn, PJ, Thomas, CM & Crump, MP, 2013, ‘A conserved motif flags acyl carrier proteins for β-branching in polyketide synthesis’. Nature Chemical Biology, vol 9., pp. 685-692 Maple, HJ, Garlish, R, Rigau-Roca, L, Porter, J, Whitcombe, I, Prosser, C, Kennedy, J, Henry, A, Taylor, R, Crump, M & Crosby, J, 2012, ‘Automated protein-ligand interaction screening by mass spectrometry’. Journal of Medicinal Chemistry, vol 55., pp. 837-851