研究领域

Organic and Biological Chemistry

Professor Russell Cox's research is focussed on the biosynthesis of biologically active compounds by microorganisms. He is particularly interested in how living systems can orchestrate complex reactions to rapidly and efficiently produce structurally diverse and complex compounds from simple precursors. Techniques in use in his research include microbiology, molecular biology, enzymology, analytical chemistry, natural products chemistry and structure elucidation using NMR and mass spectrometry. His teaching activities occur at all stages in the School of Chemistry from level I undergraduate lectures and tutorials through to postgraduate workshops and all between.

近期论文

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Yakasai, AA, Davison, J, Wasil, Z, Halo, LM, Butts, CP, Lazarus, CM, Bailey, AM, Simpson, TJ & Cox, RJ 2011, ‘Nongenetic Reprogramming of a Fungal Highly Reducing Polyketide Synthase’. Journal of the American Chemical Society, vol 133., pp. 10990-10998 Fisch, K, Bakeer, W, Yakasai, A, Song, Z, Pedrick, J, Wasil, Z, Bailey, A, Lazarus, C, Simpson, T & Cox, R 2011, ‘Rational Domain Swaps Decipher Programming in Fungal Highly Reducing Polyketide Synthases and Resurrect an Extinct Metabolite’. Journal of the American Chemical Society, vol 133., pp. 16635 - 16641 Heneghan, M, Yakasai, A, Halo, L, Song, Z, Bailey, A, Simpson, T, Cox, R & Lazarus, C 2010, ‘First Heterologous Reconstruction of a Complete Functional Fungal Biosynthetic Multigene Cluster’. ChemBioChem, vol 11., pp. 1508 - 1512 Halo, L, Marshall, J, Yakasai, A, Song, Z, Butts, C, Crump, M, Heneghan, M, Bailey, A, Simpson, T, Lazarus, C & Cox, R 2008, ‘Authentic heterologous expression of the tenellin iterative polyketide synthase nonribosomal peptide synthetase requires coexpression with an enoyl reductase’. Chembiochem : a European journal of chemical biology, vol 9., pp. 585-594 Cox, RJ 2014, ‘beta-Chain Extension: A New Mode of Carbon-Carbon Bond Formation and Chain Extension by Polyketide Synthases’. Chembiochem : a European journal of chemical biology, vol 15., pp. 27-29 Collemare, J, Griffiths, S, Iida, Y, Jashni, MK, Battaglia, E, Cox, RJ & Wit, PJGMd 2014, ‘Secondary Metabolism and Biotrophic Lifestyle in the Tomato Pathogen Cladosporium fulvum’. PLOS ONE, vol 9.