McGhee, Kevin - Bournemouth University - Department of Life & Environmental Science

个人简介

I have a BSc (Hons) in Biomedical Sciences from the University of Paisley, Scotland during which, I was awarded a Leonardo da Vinci scholarship in 1999 to work at the NAVBC University College Dublin, Ireland. After completing my degree, I returned to Ireland to undertake a Health Research Board funded PhD in Psychiatric Genetics at Trinity College Dublin, Ireland. My supervisors were Professor Michael Gill and Professor Aiden Corvin, Psychiatry, TCD. In 2006, I moved to the University of Edinburgh for post-doctoral work under the supervision of Professor Douglas Blackwood, Division of Psychiatry. I was based in the laboratory of Professor David Porteous (Medical Genetics), at the Molecular Medicine Centre. The post was funded during my time there by Generation Scotland, the Chief Scientist's Office (Scotland), Organon and Wyeth. It provided many opportunities for international collaboration: the Broad Institute (MIT and Harvard, USA); the University of North Carolina (USA); and the Centre for Molecular Medicine and Therapeutics at the University of British Columbia (Vancouver, Canada) as well as my membership of the International Schizophrenia Consortium. My second post-doctoral position was under Professor Ian Deary (Psychology, University of Edinburgh) investigating the genetics of cognitive ageing funded by a BBSRC grant and provided opportunity for collaboration with the University of Manchester. Prior to joining BU I briefly held a Teaching Fellow's post in Nursing Studies (Biology) at the University of Edinburgh under Dr Jenny Tocher and spent three years as a part time lecturer in Human Biology (concurrent with my PhD studies) within the School of Nursing and Midwifery at Trinity College Dublin (under Dr Gabrielle McKee).

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O'Dushlaine, C., McGhee, K.A. et al., 2015. Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. NATURE NEUROSCIENCE, 18 (2), 199-209. Lee, S.H., McGhee, K.A. et al., 2013. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. NATURE GENETICS, 45 (9), 984-+. Schork, A.J. et al., 2013. All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs. PLoS Genet, 9 (4), e1003449. Terwisscha van Scheltinga AF, Bakker SC, van Haren NE, Derks EM, Buizer-Voskamp JE, Boos HB, Cahn W, Hulshoff Pol HE, Ripke S, Ophoff RA, Kahn RS; Psychiatric Genome-wide Association Study Consortium, 2013. Genetic schizophrenia risk variants jointly modulate total brain and white matter volume. Biological Psychiatry. Cross-Disorder Group of the Psychiatric Genomics Consortium, Smoller JW, Craddock N, Kendler K, Lee PH, Neale BM, Nurnberger JI, Ripke S, Santangelo S, Sullivan PF., 2013. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet. Jia P, Wang L, Fanous AH, Chen X, Kendler KS; International Schizophrenia Consortium, Zhao Z., 2012. A bias-reducing pathway enrichment analysis of genome-wide association data confirmed association of the MHC region with schizophrenia. Journal of Medical Genetics. Derks EM, Vorstman JA, Ripke S, Kahn RS; Schizophrenia Psychiatric Genomic Consortium, Ophoff RA., 2012. Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis. PLoS One. Jia P, Wang L, Fanous AH, Pato CN, Edwards TL; International Schizophrenia Consortium, Zhao Z., 2012. Network-assisted investigation of combined causal signals from genome-wide association studies in schizophrenia. PLoS Computational Biology. Keller MC, Simonson MA, Ripke S, Neale BM, Gejman PV, Howrigan DP, Lee SH, Lencz T, Levinson DF, Sullivan PF; Schizophrenia Psychiatric Genome-Wide Association Study Consortium., 2012. Runs of homozygosity implicate autozygosity as a schizophrenia risk factor. PLoS Genetics. Richards AL, Jones L, Moskvina V, Kirov G, Gejman PV, Levinson DF, Sanders AR; Molecular Genetics of Schizophrenia Collaboration (MGS); International Schizophrenia Consortium (ISC), Purcell S, Visscher PM, Craddock N, Owen MJ, Holmans P, O'Donovan MC., 2012. Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain. Molecular Psychaitry, Feb17(2):, 193-201. Chen, X. et al., 2011. GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia. Molecular Psychiatry, 16 (11), 1117-1129. Sklar, P. et al., 2011. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nature Genetics, 43 (10), 977-985. Ripke, S. et al., 2011. Genome-wide association study identifies five new schizophrenia loci. Nature Genetics, 43 (10), 969-978. Davies, G., McGhee, K. et al., 2011. Genome-wide association studies establish that human intelligence is highly heritable and polygenic. Mol Psychiatry, 16 (10), 996-1005. Chen, J., Lee, G., Fanous, A.H., Zhao, Z., Jia, P., O'Neill, A., Walsh, D., Kendler, K.S., Chen, X. and International Schizophrenia Consortium, 2011. Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia. Schizophr Res, 131 (1-3), 43-51. Luciano, M., McGhee, K.A. et al., 2011. Whole genome association scan for genetic polymorphisms influencing information processing speed. Biol Psychol, 86 (3), 193-202. Bridges M, Heron EA, O'Dushlaine C, Segurado R; International Schizophrenia Consortium (ISC), Morris D, Corvin A, Gill M, Pinto C., 2011. Genetic classification of populations using supervised learning. PLoS One. Chen J, Lee G, Fanous AH, Zhao Z, Jia P, O'Neill A, Walsh D, Kendler KS, Chen X; International Schizophrenia Consortium., 2011. Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia. Schizophrenia Research. Houlihan, L.M., McGhee, K.A. et al., 2010. Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time. American Journal of Human Genetics, 86, 626-31. Gilks, W.P., Allott, E.H., Donohoe, G., Cummings, E., Consortium, I.S., Gill, M., Corvin, A.P., Morris, D.W. and McGhee, K.A., 2010. Replicated genetic evidence supports a role for HOMER2 in schizophrenia. Neuroscience Letters, 468, 229-33.