Bower, John - University of Bristol

个人简介

2020 – present Regius Professor of Chemistry, University of Liverpool. 2020 – present Visiting Professor of Chemistry, University of Bristol. 2017 – 2020 Professor of Chemistry, University of Bristol. 2016 – 2017 Reader in Organic Chemistry, University of Bristol. 2015 – 2016 Senior Research Fellow/Senior Lecturer, University of Bristol. 2014 – 2015 Proleptic Lectureship, University of Bristol. 2010 – 2018 Royal Society University Research Fellow, University of Bristol. 2008 – 2010 Postdoctoral Associate, University of Oxford (T. J. Donohoe). 2007 – 2008 Postdoctoral Associate, University of Texas at Austin (M. J. Krische). 2003 – 2007 PhD, University of Bristol (T. Gallagher). 1999 – 2003 MSci (Hons., 1st class), University of Bristol. John Bower obtained his MSci degree in Chemistry in 2003 from the University of Bristol. He then remained at Bristol to study for his PhD degree (2007) under the guidance of Professor Timothy Gallagher. During this time his research focused on the development of cyclic sulfamidate based N-heterocyclic methodologies and their application to natural product synthesis. His first postdoctoral appointment (2007-2008) was with Professor Michael Krische at the University of Texas at Austin where he investigated transfer hydrogenative strategies for carbonyl addition. He then undertook a second postdoctoral appointment with Professor Timothy Donohoe at the University of Oxford where he focussed on the use of olefin cross metathesis for heteroaryl synthesis. In 2010, he was awarded a Royal Society University Research Fellowship and commenced his independent career at the University of Bristol. In 2020, he was appointed to the Regius Chair of Chemistry at the University of Liverpool. The group’s research interests lie broadly within the area of asymmetric catalysis with a particular focus on metal-catalysed processes and their application to heterocyclic chemistry. A special emphasis is placed on the development of green processes (i.e. atom economy, step economy and selectivity).

研究领域

Research in the Bower Group is driven by the discovery and development of fundamentally new carbon-carbon and carbon-heteroatom bond forming processes. In particular, we target methods that are operationally simple, green (atom and step economy) and selective (chemo-, regio- and stereoselectivity). In this context, asymmetric transition metal-catalysed processes are of particular interest. The discovery of fundamental reactivity naturally leads to new opportunities in synthetic methodology, total synthesis and mechanism. Current research efforts are focused upon (i) the development of new methodology for heterocyclic chemistry, (ii) the application of these processes to natural product synthesis, (iii) the evaluation of natural product analogues for medicinal purposes and (iv) understanding reaction mechanism to increase the efficiency, scope and applicability of new transformations.

近期论文

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R. L. de Carvalho, J. M. Wood, R. G. Almeida, N. G. Berry, E. N. da Silva Júnior* and J. F. Bower*; The synthesis and reactivity of naphthoquinonynes. Angew. Chem. Int. Ed. 2024, In press. F. Hong, T. P. Aldhous, P. D. Kemmitt and J. F. Bower*; A directed enolization strategy enables byproduct free construction of contiguous stereocentres en route to complex amino acids. Nat. Chem. 2024, In press. C. Jing, W. Mao and J. F. Bower*; Iridium-catalyzed enantioselective alkene hydroalkylation via a heteroaryl-directed enolization-decarboxylation sequence. J. Am. Chem. Soc. 2023, 145, 23918-23924. M. J. S. Smith, W. Tu, C. M. Robertson and J. F. Bower*; Stereospecific aminative cyclizations triggered by intermolecular aza-Prilezhaev alkene aziridination. Angew. Chem. Int. Ed. 2023, 62, e202312797. (Highlighted in Org. Process Res. Dev. DOI: 10.1021/acs.oprd.3c00460) S. A. Scott, J. A. Cadge, G. K. Boden, J. F. Bower* and C. A. Russell*; A hemilabile NHC-gold complex and its application to the redox neutral 1,2-oxyarylation of feedstock alkenes. Angew. Chem. Int. Ed. 2023, 62, e202301526. Y. Zhu, M. J. S. Smith, W. Tu and J. F. Bower*; A stereospecific alkene 1,2-aminofunctionalization platform for the assembly of complex nitrogen containing ring systems. Angew. Chem. Int. Ed. 2023, 62, e202301262. R. J. Adams, P. G. Pringle* and J. F. Bower*; 1,3,5,7-Tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane in e-EROS Encyclopedia of Reagents for Organic Synthesis, Wiley-VCH, 2023, In press. O. O. Sokolova, A. G. Dalling and J. F. Bower*; C-C bond activations of minimally activated cyclopropanes. Synlett 2023, 34, 1317-1326. Invited contribution to a special issue in honour of Professor Masahiro Murakami. J. A. Cadge, P. J. Gates, J. F. Bower* and C. A. Russell*; Migratory insertion of CO into a Au-C bond. J. Am. Chem. Soc. 2022, 144, 19719-19725. C. Jing, B. T. Jones, R. J. Adams and J. F. Bower*; Cyclopropane-fused N-heterocycles via aza-Heck triggered C(sp3)-H functionalization cascades. J. Am. Chem. Soc. 2022, 144, 16749-16754. P. Cooper, A. G. Dalling, E. H. E. Farrar, T. P. Aldhous, S. Grélaud, E. Lester, L. J. Feron, P. D. Kemmitt, M. N. Grayson* and J. F. Bower*; Atom and step economical synthesis of acyclic quaternary centers via iridium-catalyzed hydroarylative cross-coupling of 1,1-disubstituted alkenes. Chem. Sci. 2022, 13, 11183-11189. A. D. J. Calow, D. Dailler and J. F. Bower*; Carbonylative N-heterocyclization via nitrogen-directed C-C bond activation of non-activated cyclopropanes. J. Am. Chem. Soc. 2022, 144, 11069-11074. O. O. Sokolova and J. F. Bower*; An endo-directing group strategy unlocks enantioselective (3+1+2) carbonylative cycloadditions of aminocyclopropanes. Angew. Chem. Int. Ed. 2022, 61, e202205007. G. A. M. Jardim, R. L. de Carvalho, M. P. Nunes, L. A. Machado, L. D. Almeida, K. A. Bahou, J. F. Bower* and E. N. da Silva Júnior*; Looking deep into C–H functionalization: the synthesis and application of cyclopentadienyl and related metal catalysts. Chem. Commun. 2022, 58, 3101-3121. Invited contribution to a thematic collection on the “Functionalization of unreactive C-H bonds”. J. A. Cadge, J. F. Bower* and C. A. Russell*; A systematic study of the effects of complex structure on aryl iodide oxidative addition at bipyridyl-ligated Au(I) centers. Angew. Chem. Int. Ed. 2021, 60, 24976-24981. (open access) B. T. Jones, J. García-Cárceles, L. Caiger, I. R. Hazelden, R. J. Lewis, T. Langer and J. F. Bower*; Complex polyheterocycles and the stereochemical reassignment of pileamartine A via aza-Heck triggered aryl C-H functionalization cascades. J. Am. Chem. Soc. 2021, 143, 15593-15598. (open access) C. Jing, J. J. Farndon and J. F. Bower*; Dearomatizing amination reactions. Chem. Rec. 2021, 21, 2909-2926. Invited contribution to the special issue for the 18th Brazilian Meeting on Organic Synthesis (BMOS). L. G. O’Neil and J. F. Bower*; Electrophilic aminating agents in total synthesis. Angew. Chem. Int. Ed. 2021, 60, 25640-25666. T. P. Aldhous, R. W. M. Chung, A. G. Dalling and J. F. Bower*; Enantioselective intermolecular Murai-type alkene hydroarylation reactions. Synthesis 2021, 53, 2961-2975. Invited contribution to a special issue in honour of Professor Shinji Murai. O. O. Sokolova and J. F. Bower*; Selective carbon-carbon bond cleavage of cyclopropylamine derivatives. Chem. Rev. 2021, In press. Invited contribution to the 2021 thematic issue on “Carbon-Carbon Bond Cleavage in Stereoselective Synthesis.” G.-W. Wang, O. O. Sokolova, T. A. Young, E. M. S. Christodoulou, C. P. Butts and J. F. Bower*; Carbonylative C-C bond activation of aminocyclopropanes using a temporary directing group strategy. J. Am. Chem. Soc. 2020, In press. L. Dantas-Pereira, E. F. Cunha-Junior, V. V. Andrade-Neto, J. F. Bower, G. A. M. Jardim, E. N. da Silva Júnior, E. C. Torres-Santos and R. F. S. Menna-Barreto*; Naphthoquinones and derivatives for chemotherapy: perspectives and limitations of their anti-trypanosomatids activities. Curr. Pharm. Des. 2020, In press. J. García-Cárceles, K. A. Bahou, and J. F. Bower*; Recent methodologies that exploit oxidative addition of C-N bonds to transition metals. ACS Catal. 2020, In press. J. M. Wood, N. S. Satam, R. G. Almeida, V. S. Cristani, D. P. Lima, L. D. Pereira, K. Salomão, R. F. S. Menna-Barreto, I. N. N. Namboothiri,* J. F. Bower* and E. N. da Silva Júnior*; Strategies towards potent trypanocidal drugs: application of Rh-catalyzed [2+2+2] cycloadditions, sulfonyl phthalide annulation and nitroalkene reactions for the synthesis of substituted quinones and their evaluation against Trypanosoma cruzi. Bioorg. Med. Chem. 2020, 28, 115565. A. S. Henderson, J. F. Bower* and M. C. Galan*; Pseudo-enantiomeric carbohydrate-based N-heterocyclic carbenes as promising chiral ligands for enantiotopic discrimination. Org. Biomol. Chem. 2020, 18, 3012-3016. Invited contribution to the themed collection on “Glycosylation: new methodologies for oligosaccharide and glycoconjugate synthesis and their applications”. J. A. Cadge, H. A. Sparkes, J. F. Bower* and C. A. Russell*; Oxidative addition of alkenyl and alkynyl iodides to a Au(I) complex. Angew. Chem. Int. Ed. 2020, 59, 6617-6621. G.-W. Wang, O. Boyd, T. A. Young, S. M. Bertrand and J. F. Bower*; Rhodacyclopentanones as linchpins for the atom economical assembly of diverse polyheterocycles. J. Am. Chem. Soc. 2020, 142, 1740-1745. J. M. Wood, E. N. da Silva Júnior* and J. F. Bower*; Rh-catalyzed [2+2+2] cycloadditions with benzoquinones: de novo access to naphthoquinones for lignan and type II polyketide synthesis. Org. Lett. 2020, 22, 265-269. O. Boyd, G.-W. Wang, O. O. Sokolova, A. D. J. Calow, S. M. Bertrand and J. F. Bower*; Modular access to eight-membered N-heterocycles by directed carbonylative C-C bond activation of aminocyclopropanes. Angew. Chem. Int. Ed. 2019, 58, 18844-18848. X. Ma, I. R. Hazelden, T. Langer, R. H. Munday and J. F. Bower*; Enantioselective aza-Heck cyclizations of N-(tosyloxy)carbamates: synthesis of pyrrolidines and piperidines. J. Am. Chem. Soc. 2019, 141, 3356-3360. (Highlighted in SYNFACTS 2019, 15, 483) A. G. Dalling, T. Yamauchi, N. G. McCreanor, L. Cox and J. F. Bower*; Carbonylative C-C bond activation of electron-poor cyclopropanes: rhodium-catalyzed (3+1+2) cycloadditions of cyclopropylamides. Angew. Chem. Int. Ed. 2019, 58, 221-225. A. D. J. Calow and J. F. Bower*; Rhodium(I)-catalyzed reductive carbon-carbon bond formation in Rhodium catalysis in organic synthesis: methods and reactions, K. Tanaka (Ed.), Wiley-VCH, 2019, pp 133-160. (book chapter) J. J. Farndon, T. A. Young and J. F. Bower*; Stereospecific alkene aziridination using a bifunctional amino-reagent: an aza-Prilezhaev reaction. J. Am. Chem. Soc. 2018, 140, 17846-17850. P. Cooper, G. E. M. Crisenza, L. J. Feron and J. F. Bower*; Iridium-catalyzed α-selective arylation of styrenes by dual C-H functionalization. Angew. Chem. Int. Ed. 2018, 57, 14198-14202. S. Grélaud, P. Cooper, L. J. Feron and J. F. Bower*; Branch-selective and enantioselective iridium-catalyzed alkene hydroarylation via anilide-directed C-H oxidative addition. J. Am. Chem. Soc. 2018, 140, 9351-9356. (Highlighted in SYNFACTS 2018, 14, 1165; Highlighted in Org. Process Res. Dev. 2019, 23, 2287−2301) A. G. Dalling and J. F. Bower*; Synthesis of nitrogen heterocycles via directed carbonylative C-C bond activation of cyclopropanes. Chimia 2018, 72, 595-600. (review article) M. J. Harper, C. J. Arthur, J. Crosby, E. J. Emmett, R. L. Falconer, A. J. Fensham-Smith, P. J. Gates, T. Leman, J. E. McGrady,* J. F. Bower* and C. A. Russell*; Oxidative addition, transmetallation and reductive elimination at a 2,2′-bipyridyl ligated gold center. J. Am. Chem. Soc. 2018, 140, 2743-2747. (open access) I. R. Hazelden, R. C. Carmona, T. Langer, P. G. Pringle and J. F. Bower*; Pyrrolidines and piperidines by ligand-enabled aza-Heck cyclizations and cascades of N-(pentafluorobenzoyloxy)carbamates. Angew. Chem. Int. Ed. 2018, 57, 5124-5128. (open access) G.-W. Wang and J. F. Bower*; Modular access to azepines by directed carbonylative C-C bond activation of aminocyclopropanes. J. Am. Chem. Soc. 2018, 140, 2743-2747. (open access)