Wheatley, Mark - University of Birmingham

个人简介

2007-present Chair of Biochemical Pharmacology.University of Birmingham. 2005-2007 Reader in Biochemistry, University of Birmingham. 1995-2005 Senior Lecturer in Biochemistry, University of Birmingham. 1988-1995 Lecturer in Biochemistry, University of Birmingham/

近期论文

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Wheatley, M., Wootten, D., Conner, M.T., Simms, J., Kendrick, R., Logan, R.T., Poyner, D.R. and Barwell, J. (2011) Lifting the lid on G-protein-coupled receptors: The role of the extracellular loops. Brit. J. Pharmacol. (in press). Wootten, D.L., Simms, J., Massoura, A.J., Trim, J.E. and Wheatley, M. (2011) Agonist-specific requirement for a glutmate in transmembrane helix 1 of the oxytocin receptor. Mol. Cell. Endocrinol, 333, 20-27. Jamshad, M., Lin, Y.P., Knowles, T.J., Parslow, R.A., Harris, C., Wheatley, M., Poyner, D.R., Bill, R.M., Thomas, O.R., Overduin, M., Dafforn, T.R. (2011) Surfactant-free purification of membrane proteins with intact native membrane environment. Biochem. Soc. Trans. 39: 813-818. Qi, T., Simms, J., Bailey, R.J., Wheatley, M., Rathbone, D.L., Hay, D.L. and Poyner, D.R. (2010) Structure-function analysis of RAMP1-RAMP3 chimeras. Biochemistry 49: 522-531. Mumford, A.D., Dawood, B.B., Daly, M.E., Murden, S.L., Williams, M.D., Protty, M.B., Spalton, J.C., Wheatley, M., Mundell, S.J. and Watson, S. (2010) A novel thromboxane A2 receptor D304N variant which abrogates ligand binding in a patient with a bleeding diathesis. Blood 115: 363-369. Simms, J., Hay, D.L., Bailey, R.J., Konycheva, G., Bailey, G., Wheatley, M. and Poyner, D.R. (2009) Structure-function analysis of RAMP1 by alanine mutagenesis. Biochemistry 48: 198-205. MacKinnon, A.C., Tufail-Hanif, U., Wheatley, M., Rossi, A.G., Haslett, C., Seckl, M. and Sethi, T. (2009) Targeting V1a vasopressin receptors with [Arg6, D-Trp7,9, NmePhe8]Substance P (6-11) identifies a strategy to develop novel anti-cancer therapies. Brit. J. Pharmacol. 156: 36-47. Conner, M., Hicks, M.R., Dafforn, T., Knowles, T.J., Ludwig, C., Staddon, S., Overduin, M., Günther, U.L., Thome, J., Wheatley, M., Poyner, D.R. and Conner, A.C. (2008) Functional and biophysical analysis of the C-terminus of the CGRP-receptor; a Family B GPCR. Biochemistry 47: 8434-8444. Conner, M., Hawtin, S.R., Simms, J., Wootten, D., Lawson, Z., Conner, A., Parslow, R.A. and Wheatley, M. (2007) Systematic analysis of the entire second extracellular loop of the V1a vasopressin receptor: key residues, conserved throughout a G-protein-coupled receptor family, identified. J. Biol. Chem. 282: 17405-17412. Wheatley, M., Simms, J., Hawtin, S.R., Wesley, V.J., Wootten, D., Conner, M., Lawson, Z., Conner, A.C., Baker, A., Cashmore, Y., Kendrick, R. and Parslow, R.A. (2007) Extracellular loops and ligand binding to a sub-family of Family A G-protein-coupled receptors. Biochem. Soc. Trans. 35: 717-720. Hawtin, S.R., Simms, J., Conner, M., Lawson, Z., Parslow, R.A., Trim, J., Sheppard A. and Wheatley, M. (2006) Charged extracellular residues, conserved throughout a G-protein-coupled receptor family, are required for ligand binding, receptor activation and cell-surface expression. J. Biol. Chem. 281: 38478-38488. Conner, A.C., Simms, J., Conner, M.T., Wootten, D.L., Wheatley, M. and Poyner, D.R. (2006) Diverse functional motifs within the three intracellular loops of the CGRP1 receptor. Biochemistry 45: 12976-12985. Simms, J., Hay, D.L., Wheatley, M. and Poyner, D.R. (2006) Characterization of the structure of RAMP1 by mutagenesis and molecular modeling. Biophys. J. 91: 662-669. Conner, A.C., Simms, J., Howitt, S.G., Wheatley, M. and Poyner, D.R. (2006) The second intracellular loop of the CGRP-receptor provides molecular determinants for signal transduction and cell surface expression. J. Biol. Chem. 281: 1644-1651. Hawtin, S.R., Wesley, V.J., Simms, J., Argent, C.H., Latif, K. and Wheatley, M. (2005) The N-terminal juxtamembrane segment of the V1a vasopressin receptor provides two independent epitopes required for high affinity agonist binding and signaling. Mol. Endocrinol. 19: 2871-2881. Hawtin, S.R., Ha, S.N., Pettibone, D.J. and Wheatley, M. (2005) A Gly/Ala switch contributes to high affinity binding of benzoxazinone-based non-peptide oxytocin receptor antagonists. FEBS Letts. 579: 349-356.