Viant, Mark - University of Birmingham

个人简介

On completion of a BSc in Chemistry (1991) and PhD in Chemical Physics (1994), both at the University of Southampton, Viant spent almost a decade in the USA, initially as a Royal Commission for the Exhibition of 1851 Postdoctoral Researcher at the University of California (UC) Berkeley (chemistry) and subsequently as a postdoctoral researcher and then independent faculty member at UC Davis (environmental toxicology). Here, he pioneered the application of metabolomics to environmental health issues in aquatic organisms. In 2003 he relocated to the University of Birmingham as a NERC Advanced Fellow with the remit to further develop metabolomics in environmental toxicology. With funding from the NERC, BBSRC, MRC, Wellcome Trust, Wolfson Foundation, EU, Environment Agency and several US agencies, Viant has established a large and active research group in environmental metabolomics. In 2008 he was appointed to Reader in Metabolomics, in 2009 became the Director of the NERC Biomolecular Analysis Facility for Metabolomics, and in 2010 secured his current Chair in Metabolomics. He has served as the President of the international Metabolomics Society since 2012. His achievements in metabolomics research have recently been recognised by the University of Birmingham’s highest award, the Joseph Chamberlain Award for Academic Advancement (2013)

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L. Mirbahai, A. D. Southam, U. Sommer, T. D. Williams, J. P. Bignell, M. R. Viant, J. K. Chipman, Disruption of DNA methylation via S-adenosylhomocysteine is a key process in high incidence liver carcinogenesis in fish. J. Proteome Research 12, 2895-2904 (2013). J. A. Kirwan, D. I. Broadhurst, R. L. Davidson, M. R. Viant, Characterising and correcting batch variation in an automated direct infusion mass spectrometry (DIMS) metabolomics workflow. Anal. Bioanal. Chem. 405, 5147-5157 (2013). W. B. Dunn, A. Erban, R. J. M. Weber, D. J. Creek, M. Brown, R. Breitling, T. Hankemeier, R. Goodacre, S. Neumann, J. Kopka, M. R. Viant, Mass appeal: metabolite identification in mass spectrometry-focused untargeted metabolomics. Metabolomics 9, S44-66 (2013). M. R. Viant, and U. Sommer, Mass spectrometry based environmental metabolomics: A primer and review. Metabolomics 9, S144-158 (2013). R. J. M. Weber, E. Li, J. Bruty, S. He, M. R. Viant, MaConDa: a publicly accessible Mass spectrometry Contaminants Database. Bioinformatics 28, 2856-2857 (2012). C. Ludwig, J. M. Easton, A. Lodi, S. Tiziani, S. Manzoor, A. D. Southam, J. J. Byrne, L. M. Bishop, S. He, T. N. Arvanitis, U. L. Günther, M. R. Viant, Birmingham Metabolite Library: A publicly accessible database of 1-D 1H and 2-D 1H J-resolved NMR spectra of authentic metabolite standards (BML-NMR). Metabolomics 8, 8-18 (2012). O. Hrydziuszko, M. R. Viant, Missing values in mass spectrometry based metabolomics: an undervalued step in the data processing pipeline. Metabolomics 8, 161-174 (2012). T. D. Williams, N. Turan, A. M. Diab, H. Wu, C. Mackenzie, K. L. Bartie, O. Hrydziuszko, B. P. Lyons, G. D. Stentiford, M. J. Herbert, K. J. Abraham, I. Katsiadaki, M. J. Leaver, J. B. Taggart, S. G. George, M. R. Viant, J. K. Chipman, F. Falciani, Towards a System Level Understanding of Non-Model Organisms Sampled from the Environment: A Network Biology Approach. PLoS Comp. Biol. 7, e1002126 (2011). I. R?mer, T. A. White, M. Baalousha, J. K. Chipman, M. R. Viant, J. R. Lead, Aggregation and dispersion of silver nanoparticles in exposure media for aquatic toxicity tests. J. Chromatogr. A 1218, 4226-4233 (2011). R. J. M. Weber, A. D. Southam, U. Sommer, M. R. Viant, Characterization of isotopic abundance measurements in high resolution FT-ICR and Orbitrap mass spectra for improved confidence of metabolite identification. Anal. Chem. 83, 3737-3743 (2011). A. D. Southam, A. Lange, A. Hines, E. M. Hill, Y. Katsu, T. Iguchi, C. R. Tyler, M. R. Viant, Metabolomics reveals target and off-target toxicities of a model organophosphate pesticide to roach (Rutilus rutilus): Implications for biomonitoring. Environ. Sci. Technol. 45, 3759-3767 (2011). H. C. Poynton, N. S. Taylor, J. Hicks, K. Colson, S. Chan, C. Clark, L. Scanlan, A. V. Loguinov, C. Vulpe, M. R. Viant, Metabolomics of Microliter Hemolymph Samples Enables an Improved Understanding of the Combined Metabolic and Transcriptional Responses of Daphnia magna. Environ. Sci. Technol. 45, 3710-3717 (2011). N. S. Taylor, R. J. M. Weber, T. A. White, M. R. Viant, Discriminating between different acute chemical toxicities via changes in the daphnid metabolome. Toxicol. Sci. 118, 307–317 (2010). R. J. M. Weber, M. R. Viant, MI-Pack: Increased confidence of metabolite identification in mass spectra by integrating accurate masses and metabolic pathways. Chemometrics and Intelligent Laboratory Systems 104, 75-82 (2010). A. Hines, F. J. Staff, J. Widdows, R. Compton, F. Falciani, M. R. Viant, Discovery and validation of metabolic signatures for predicting whole organism toxicology. Toxicol. Sci. 115, 369-378 (2010) – selected as Highlight Article for this Issue. E. M. Santos, J. S. Ball, T. D. Williams, H. Wu, F. Ortega, R. van Aerle, I. Katsiadaki, F. Falciani, M. R. Viant, J. K. Chipman, C. R. Tyler, Identifying health impacts of exposure to copper using transcriptomics and metabolomics in a fish model. Environ. Sci. Technol. 44, 820-826 (2010). C. Ludwig, M. R. Viant, Two-dimensional J-resolved NMR spectroscopy: Review of a key methodology in the metabolomics toolbox. Phytochemical Analysis 21, 22-32 (2010). T. G. Payne, A. D. Southam, T. N. Arvanitis, M. R. Viant, A signal filtering method for improved quantification and noise discrimination in Fourier transform ion cyclotron resonance mass spectrometry-based metabolomics data. J. Amer. Soc. Mass Spectrom. 20, 1087-1095 (2009). N. S. Taylor, R. J. M. Weber, A. D. Southam, T. G. Payne, O. Hrydziuszko, T. N. Arvanitis, M. R. Viant, A new approach to toxicity testing in Daphnia magna: Application of high throughput FT-ICR mass spectrometry metabolomics. Metabolomics 5, 44-58 (2009). J. G. Bundy, M. P. Davey, M. R. Viant, Environmental metabolomics: A critical review and future perspectives. Metabolomics 5, 3-21 (2009).