Tomlinson, Michael - University of Birmingham

个人简介

Dr Mike Tomlinson grew up in Birmingham before studying as an undergraduate at the University of Bath. His postdoctoral studies were carried out at the Sir William Dunn School of Pathology with Drs Neil Barclay, Alan Williams and Mark Wright, as a member of Magdalen College, University of Oxford. He worked on tetraspanins on immune cells at a time when the field was in its infancy. In 1996 he moved to the United States to study signal transduction by immune cell antigen receptors as a post-doctoral researcher, firstly with Drs Joe Bolen and Jim Johnston at DNAX Research Institute in Palo Alto, and secondly with Dr Art Weiss at the University of California in San Francisco. Dr Tomlinson returned to the United Kingdom in 2004 to join Dr Steve Watson’s empire in the University of Birmingham Medical School. He soon began his own research group through a MRC New Investigator Award fellowship to study the regulation of platelet receptor signalling by tetraspanin microdomains. In 2009 he joined the School of Biosciences, funded by a Senior Fellowship from the British Heart Foundation, to study the organisation of platelet and endothelial cell surface proteins by tetraspanin microdomains

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Rubinstein E, Charrin S and Tomlinson MG (2013). Organisation of tetraspanin web. In Tetraspanins (Berditchevski F and Rubinstein E, eds), Springer, Dordrecht, pp. 47-90. Haining EJ, Yang J, Bailey RL, Khan K, Collier R, Tsai S, Watson SP, Frampton J, Garcia P and Tomlinson MG (2012). The TspanC8 subgroup of tetraspanins interacts with a disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression. J. Biol. Chem. 287: 39753-39765. Bailey RL, Herbert JM, Kabir K, Heath VL, Bicknell R and Tomlinson MG (2011). The emerging role of tetraspanin microdomains on endothelial cells. Biochem. Soc. Trans. 39: 1667–1673. Tomlinson MG (2011). Analysis of the platelet and megakaryocyte transcriptomes using serial analysis of gene expression. In Platelet Proteomics (Garcia A and Senis YA, eds), Wiley, pp. 209-230. Haining EJ, Yang J and Tomlinson MG (2011). Tetraspanin microdomains: fine-tuning platelet function. Biochem. Soc. Trans. 39: 518-523. Hughes CE, Pollitt AY, Mori J, Eble JA, Tomlinson MG, Hartwig JH, O’Callaghan CA, Futterer K and Watson SP (2010). CLEC-2 activates Syk through dimerisation. Blood 115: 2947-2955. Tomlinson MG (2009). Platelet tetraspanins: small but interesting. J. Thromb. Haemost. 7: 2070-2073. Senis YA*, Tomlinson MG*, Ellison S, Mazharian A, Lim J, Zhao Y, Kornerup KN, Auger JM, Thomas SG, Dhanjal T, Kalia N, Zhu JW, Weiss A and Watson SP. (2009). The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis. Blood 113: 4942-4954. (*Denotes joint first author). Protty MB, Watkins NA, Colombo D, Thomas SG, Heath VL, Herbert JMJ, Bicknell R, Senis YA, Ashman LK, Berditchevski F, Ouwehand WH, Watson SP and Tomlinson MG (2009). Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains. Biochem. J. 417: 391-400. Mori J, Pearce AC, Spalton JC, Grygielska B, Eble JA, Tomlinson MG, Senis YA and Watson SP. (2008). G6b-B inhibits constitutive and agonist-induced signalling by GPVI and CLEC-2. J. Biol. Chem. 283: 35419-35427. Tomlinson MG, Calaminus SD, Berlanga O, Auger JM, Bori-Sanz T, Meyaard L and Watson SP (2007). Collagen promotes sustained GPVI signalling in platelets and cell lines. J. Thromb. Haemost.5: 2274-2283. Senis YA, Tomlinson MG, Garcia A, Dumon S, Heath VL, Herbert J, Cobbold SP, Spalton JC, Ayman S, Antrobus R, Zitzmann N, Bicknell R, Frampton J, Authi KS, Martin A, Wakelam MJ and Watson SP (2007). A comprehensive proteomics and genomics analysis reveals novel transmembrane proteins in human platelets and mouse megakaryocytes including G6b-B, a novel immunoreceptor tyrosine-based inhibitory motif protein. Mol. Cell. Prot. 6: 548-564. Fuller GL, Williams JA, Tomlinson MG, Eble JA, Hanna SL, Pohlmann S, Suzuki-Inoue K, Ozaki Y, Watson SP and Pearce AC (2007). The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signalling cascade. J. Biol. Chem. 282: 12397-12409. Berlanga O, Bori-Sanz T, James JR, Frampton J, Davis SJ, Tomlinson MG and Watson SP (2007). GPVI oligomerisation in cell lines and platelets. J. Thromb. Haemost 5: 1026-1033. Garcia A, Senis Y, Tomlinson MG and Watson SP (2006). Platelet genomics and proteomics. In Platelets (Michelson AD, ed), Academic Press/Elsevier Science, New York, pp. 99-116.