Murphy, Carol - University of Birmingham

个人简介

Carol Murphy has a BSc and PhD from University College Dublin, Ireland. She worked with Ulrich Rüther as a post-doctoral fellow at the Differentiation Programme at the European Molecular Biology Laboratory (EMBL) and also in the Cell Biology Programme at the EMBL in the laboratory of Marino Zerial, Heidelberg, Germany. She then moved to the Laboratory of Biological Chemistry at the University of Ioannina (UOI) Medical School, Greece, where she was funded by the EU as “Experienced Scientist”. Since 2001 she has been working as Researcher B at IMBB-BR. Her research interests include the intracellular trafficking of receptors and the control of signalling with extension to human stem cells and human induced pluripotent stem cells. In July 2015 she moved to the School of Biosciences, University of Birmingham as Senior Lecturer in Advanced Biological Imaging.

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Dimitris Basagiannis, Sofia Zografou, Carol Murphy, Theodore Fotsis, Lucia Morbidelli, Marina Ziche, Christopher Bleck, Jason Mercer, and Savvas Christoforidis. VEGF induces signalling and angiogenesis by directing VEGFR2 internalisation via macropinocytosis. J. Cell Sci 2016 in press. Tsolis K, Bagli E, Kanaki K, Zografou S, Carpentier S, Bei E, Savvas Christoforidis S, Zervakis M, Murphy C, Fotsis T, Economou A. Proteome changes during transition from human embryonic to vascular progenitor cells. Accepted in J Proteome Research, 2016, 15: 1995-2007. Kyrkou A, Stellas D, Syrrou M, Klinakis A, Fotsis T, Murphy C: Generation of human induced pluripotent stem cells in defined, feeder-free conditions. Lab Resource, Stem Cell Research, 2016 in press. http://www.sciencedirect.com/science/article/pii/S1873506116300381 Kouroupis D, Kyrkou A, Triantafyllidi E, Katsimpoulas M, Chalepakis G, Goussia A, Georgoulis A, Murphy C, Fotsis T: Generation of stem cell-based bioartificial anterior cruciate ligament (ACL) grafts for effective ACL rupture repair. Stem Cell Research, 2016 in press. http://www.ncbi.nlm.nih.gov/pubmed/27217303 Karali E, Bellou S, Stellas Dimitris, Klinakis Apostolos Murphy C, Fotsis T: ER mediates induction of endothelial cell survival and angiogenesis by VEGF: PLCg via mTORC1 activates ATF6 and PERK. Mol. Cell 2014, 54: 559-72. Kostaras E, Pedersen NM, Stenmark H, Fotsis T, Murphy C: SARA and RNF11 at the crossroads of EGFR signalling and trafficking. Methods Enzymol 2014, 535: 225-47. Bellou S, Pentheroudakis G, Murphy C, Fotsis T: Anti-angiogenesis in cancer therapy: Hercules and Hydra. Cancer Lett. 2013, 338: 291-28. Kyrkou A, Soufi M, Bahtz R, Ferguson C, Bai M, Parton RG, Hoffmann I, Zerial M, Fotsis T, Murphy C: RhoD participates in the regulation of cell-cycle progression and centrosome duplication. Oncogene 2013, 32:1831-1842. Kyrkou A, Soufi M, Bahtz R, Ferguson C, Bai M, Parton RG, Hoffmann I, Zerial M, Fotsis T, Murphy C: The RhoD to centrosomal duplication. Small GTPases 2013, 4: 116-22. Kostaras E, Sflomos G, Pedersen NM, Stenmark H, Fotsis T*, Murphy C*: SARA and RNF11 interact with each other and ESCRT-0 core proteins and regulate degradative EGFR trafficking. Oncogene 2013, 32: 5220-32. * joint last authors. Bellou S, Karali E, Bagli E, Al-Maharik N, Morbidelli L, Ziche M, Adlercreutz H, Murphy C, Fotsis T: The isoflavone metabolite 6-methoxyequol inhibits angiogenesis and suppresses tumor growth. Mol Cancer 2012, 11:35. Sflomos G, Kostaras E, Panopoulou E, Pappas N, Kyrkou A, Politou AS, Fotsis T, Murphy C: ERBIN is a new SARA-interacting protein: competition between SARA and SMAD2 and SMAD3 for binding to ERBIN. J Cell Sci 2011, 124:3209-3222. Bellou S, Hink MA, Bagli E, Panopoulou E, Bastiaens PI, Murphy C, Fotsis T: VEGF autoregulates its proliferative and migratory ERK1/2 and p38 cascades by enhancing the expression of DUSP1 and DUSP5 phosphatases in endothelial cells. Am J Physiol Cell Physiol 2009, 297:C1477-1489. Kardassis D, Murphy C, Fotsis T, Moustakas A, Stournaras C: Control of transforming growth factor beta signal transduction by small GTPases. FEBS J 2009, 276:2947-2965. Murphy C: Endo-fin-ally a SARA for BMP receptors. J Cell Sci 2007, 120:1153-1155. Fyhrquist P, Mwasumbi L, Vuorela P, Vuorela H, Hiltunen R, Murphy C, Adlercreutz H: Preliminary antiproliferative effects of some species of Terminalia, Combretum and Pteleopsis collected in Tanzania on some human cancer cell lines. Fitoterapia 2006, 77:358-366. Papanikolaou A, Papafotika A, Murphy C, Papamarcaki T, Tsolas O, Drab M, Kurzchalia TV, Kasper M, Christoforidis S: Cholesterol-dependent lipid assemblies regulate the activity of the ecto-nucleotidase CD39. J Biol Chem 2005, 280:26406-26414. Panopoulou E, Murphy C, Rasmussen H, Bagli E, Rofstad EK, Fotsis T: Activin A suppresses neuroblastoma xenograft tumor growth via antimitotic and antiangiogenic mechanisms. Cancer Res 2005, 65:1877-1886. Bagli E, Stefaniotou M, Morbidelli L, Ziche M, Psillas K, Murphy C, Fotsis T: Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3'-kinase activity. Cancer Res 2004, 64:7936-7946. Panopoulou E, Gillooly DJ, Wrana JL, Zerial M, Stenmark H, Murphy C*, Fotsis T*: Early endosomal regulation of Smad-dependent signalling in endothelial cells. J Biol Chem 2002, 277:18046-18052.* joint last authors.