Mirbahai, Leda - University of Birmingham

个人简介

Dr Leda Mirbahai completed her PhD in the field of environmental toxico-epigenomics at the University of Birmingham. Her research established a new insight into epigenetic mechanisms associated with tumourigenesis which resulted in publication of the first comprehensive DNA methylation profiling of adult zebrafish liver alongside the first application of Methylated DNA Immunoprecipitation (MeDIP) combined with de novo high-throughput DNA sequencing in any un-sequenced species. During subsequent postdoctoral appointments at the University of Birmingham and FHNW in Switzerland, she gained substantial training in the use of alternative models, such as Daphnia for epigenetic research. Dr Mirbahai joined the faculty of the University of Birmingham in August 2015, as part of the Birmingham Fellows program

近期论文

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Olsvik, P.A., Williams, T.D., Tung, H., Mirbahai, L., Sanden, M., Skjaerven, K.H., Ellingsen, S. (2014) Impacts of TCCDD and MeHg on DNA methylation in zebrafish (Danio rerio). Comp Biochem Physiol C Toxicol Pharmacol. S1532-0456(14)00077-5. Zucchi, S*., Mirbahai, L*., Castiglioni, S., Chew, G., Fent, K. (2014) Transcriptional and physiological responses induced by binary mixtures of drospirenone and progesterone in zebrafish (Danio rerio). Environ Sci Technol. 48(6): 3523-31 (* co-first author) Mirbahai, L., Chipman, J.K. (2014) Epigenetic memory of environmental organisms: a reflection of life-time stressor exposures. Mutation Research: Genet. Toxicol. Environ. Mutagen. 764-765: 10-17 Williams, T.D., Mirbahai, L., Chipman, J.K. (2014) The toxicological application of transcriptomics and epigenomics in zebrafish and other teleosts. Brief Funct Genomics. 13(2):157-71. (invited review paper) Mirbahai, L., Southam, A.D., Sommer, U., Williams, T.D., Bignell, J.P., Lyons, B.P., Viant, M.R., Chipman, J.K. (2013) Disruption of DNA methylation via S-adenosylhomocysteine is a key process in high incidence liver carcinogenesis in fish. J Proteome Res. 12(6) 2895-2904 Chan, T., Williams, T.D., Mally, A., Hamberger, C., Mirbahai, L., Hickling, K., Chipman, J.K. (2012) Gene expression and epigenetic changes by furan in rat liver. Toxicology. 292 (2-3): 63-70 Mirbahai, L., Yin, G., Bignell, J.P., Li, N., Williams, T.D., Chipman, J.K. (2011) DNA methylation in liver tumorigenesis in fish from the environment. Epigenetics. 6(11) 1319-1333 [Publication of this paper led to an interview by GenomeWeb news] Mirbahai, L., Williams, T.D., Zhan, H., Gong, Z., Chipman, J.K. (2011) Comprehensive profiling of zebrafish hepatic proximal promoter CpG island methylation and its modification during chemical carcinogenesis. BMC Genomics, 12 1-16 Mirbahai, L., Kershaw, R.M., Green, R.M., Hayden, R.E., Meldrum, R.A., Hodges, N.J. (2010) Use of a molecular beacon to track the activity of base excision repair protein OGG1 in live cells. DNA Repair, 9 144-152