Lovering, Andrew - University of Birmingham

个人简介

I grew up in Wales (Barry to be precise) and studied for both my undergraduate degree (Biochemistry) and PhD (structural biology of therapeutic enzymes) at the University of Birmingham, before beginning a 6 and a half year stint in Canada in the laboratory of Natalie Strynadka at the University of British Columbia, Vancouver. These postdoctoral years involved the study of how bacteria build their cell walls, and the associated targeting of these processes by antibiotics (funded by two fellowships from MSFHR & CIHR). I thus began a bit of a love affair with bacteria, bacterial disease, mechanisms of infection & disease control. Now, Vancouver may be the world’s most liveable city, but it’s not Birmingham. So, in 2010 I came back to the UK to start my own group looking into how we can utilise a “living antibiotic”, the bacterium Bdellovibrio bacteriovorus, to tackle bacterial pathogens

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Lambert C, Lerner TR, Bui NK, Somers H, Aizawa S, Liddell S, Clark A, Vollmer W, Lovering AL, Sockett RE. Interrupting peptidoglycan deacetylation during Bdellovibrio predator-prey interaction prevents ultimate destruction of prey wall, liberating bacterial-ghosts. Sci Rep. 2016 May 23;6:26010. Rajasekar KV, Lovering AL, Dancea F, Scott DJ, Harris SA, Bingle LE, Roessle M, Thomas CM, Hyde EI, White SA. Flexibility of KorA, a plasmid-encoded, global transcription regulator, in the presence and the absence of its operator. Nucleic Acids Res. 2016 Mar 25. Lambert C, Cadby IT, Till R, Bui NK, Lerner TR, Hughes WS, Lee DJ, Alderwick LJ, Vollmer W, Sockett ER, Lovering AL. Ankyrin-mediated self-protection during cell invasion by the bacterial predator Bdellovibrio bacteriovorus. Nat Commun. 2015 Dec 2;6:8884. Ba X, Harrison EM, Lovering AL, Gleadall N, Zadoks R, Parkhill J, Peacock SJ, Holden MT, Paterson GK, Holmes MA. Old drugs to treat resistant bugs: methicillin-resistant Staphylococcus aureus isolates with mecC are susceptible to a combination of penicillin and clavulanic acid.Antimicrob Agents Chemother. 2015 pii: AAC.01469-15 Prehna G, Ramirez, BE, Lovering AL. The Lifestyle Switch Protein Bd0108 of Bdellovibrio bacteriovorus is an Intrinsically Disordered Protein. PLoS One Dec 2014; 9(12):e115390[recommended by Faculty of 1000] Cadby IT, Lovering AL. Molecular Surveillance of the Subtle Septum: Discovering a New Mode of Peptidoglycan Synthesis in Streptococci. Mol Micro. 2014; Cadby IT, Lovering AL. Life in the “Old Bag” Yet: Structure of Peptidoglycan L,D-Carboxypeptidases. Structure. 2014; 22(7): 932-4. Ras GTPase-Like Protein MglA, a Controller of Bacterial Social-Motility in Myxobacteria, Has Evolved to Control Bacterial Predation by BdellovibrioDavid S. Milner, Rob Till, Ian Cadby, Andrew L. Lovering, Sarah M. Basford, Emma B. Saxon, Susan Liddell, Laura E. Williams, R. Elizabeth Sockett Research Article | published 10 Apr 2014 | PLOS Genetics 10.1371/journal.pgen.1004253 Structural and Biochemical Analysis of a Unique Phosphatase from Bdellovibrio bacteriovorusReveals Its Structural and Functional Relationship with the Protein Tyrosine Phosphatase Class of PhytaseRobert J. Gruninger, John Thibault, Michael J. Capeness, Robert Till, Steven C. Mosimann, R. Elizabeth Sockett, Brent L. Selinger, Andrew L. Lovering Research Article | published 09 Apr 2014 | PLOS ONE 10.1371/journal.pone.0094403 Capeness MJ, Lambert C, Lovering AL, Uchida K, Chaudhuri R, Alderwick LJ, Lee DJ-,Swarbreck D, Till R, Aizawa S-I , Sockett RE. Activity of Bdellovibriohit Locus Proteins, Bd0108 and Bd0109, Links Type IVa Pilus Extrusion/Retraction Status to Prey-Independent Growth Signalling. PLoS OneNov 2013; 10.1371/journal.pone.0079759 Lovering AL, Gretes MC, Safadi SS, Danel F, De Castro L, Page MG, Strynadka NC. Structural Insights into the Anti- Methicillin-Resistant Staphylococcus aureus (MRSA) Activity of Ceftobiprole. J Biol Chem. 2012 (Epub)http://www.ncbi.nlm.nih.gov/pubmed/22815485 Anwari K, Webb CT, Poggio S, Perry AJ, Belousoff M, Celik N, Ramm G, Lovering A, Sockett RE, Smit J, Jacobs-Wagner C, Lithgow T. The Evolution of New Protein Subunits of the Bacterial Outer Membrane BAM Complex. Mol Microbiol. 2012 84(5) 832-44http://www.ncbi.nlm.nih.gov/pubmed/22524202 Usha V, Lloyd AJ, Lovering AL, Besra GS. Structure and function of Mycobacterium tuberculosis meso-di aminopimelic acid (DAP) biosynthetic enzymes. FEMS Microbiol Lett.2012 Feb 16. doi: 10.1111Pubmed link: http://www.ncbi.nlm.nih.gov/pubmed/22339732 Lerner TR, Lovering AL, Bui NK, Uchida K, Aizawa S, Vollmer W, Sockett RE. Specialized Peptidoglycan Hydrolases Sculpt the Intra-bacterial Niche of Predatory Bdellovibrio and Increase Population Fitness. PLoS Pathog.2012 Feb;8(2):e1002524.PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22346754 Lovering AL, Capeness MJ, Lambert C, Hobley L, Sockett RE.The Structure of an unconventional HD-GYP Protein from BdellovibrioReveals the Roles of Conserved Residues in This Class of Cyclic-di-GMP Phosphodiesterases. mBio. 2011 Oct 11;2(5). Lovering AL, Safadi SS, Strynadka NCJ. Structural Perspective of Peptidoglycan Biosynthesis and Assembly. Ann Rev Biochem.2012 81. Accepted Sept 2011. Usha V, Gurcha SS, Lovering AL, Lloyd AJ, Papaemmanouil A, Reynolds RC, Besra GS.Identification of novel diphenyl urea inhibitors of Mt-GuaB2 active against Mycobacterium tuberculosis. Microbiology. 2011 157(1) 290-9. Alderwick LJ, Lloyd GS, Lloyd AJ, Lovering AL, Eggeling L, Besra GS.Biochemical characterization of the Mycobacterium tuberculosisphosphoribosyl-1-pyrophosphate synthetase. Glycobiology. 2011 21(4) 410-25. Cosgriff S, Chintakayala K, Chim YT, Chen X, Allen S, Lovering AL, Grainger DC.Dimerization and DNA-dependent aggregation of the Escherichia colinucleoid protein and chaperone CbpA. Mol Microbiol. 2010 77(5) 1289-300. Lovering AL, Lin LC, Sewell EW, Brown ED, Strynadka NC.Structure of the cell wall teichoic acid polymerase TagF: details of membrane-binding and catalysis. Nature Struct Mol Biol. 2010 17(5) 582-9.