Leach, Lindsey Jane - University of Birmingham

个人简介

Lindsey gained a PhD in Statistical Genetics at the University of Birmingham under the supervision of Professor Z Luo and Professor Michael J Kearsey. She then worked with Professor Nicholas Harberd as a Postdoctoral Researcher in the Department of Plant Sciences, University of Oxford and gained experience in next generation sequencing and bioinformatic analysis of polyploid plant genomes. Lindsey returned to Birmingham appointed as a Birmingham Fellow in the School of Biosciences in March 2012.

研究领域

My research interests lie in the dissection of complex trait phenotypes in human, plant and animal populations into their underlying genetic components. This central problem in statistical genetics consists of multiple interrelated parts, from genetic and epigenetic studies to identify genetic variants involved, transcriptomics to explore the genome-wide expression patterns, to the related fields of proteomics and metabolomics. Integrating knowledge from each level of information has the potential to build realistic understanding of the molecular networks underpinning complex trait variation.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Leach, L.J., Belfield, E., Jiang, C. et al. (2014). Patterns of homoeologous gene expression shown by RNA sequencing in hexaploid bread wheat. BMC Genomics. 15: 276. Wang, L., Jiang, N., Wang, L., Fang, O., Leach, L.J., et al. 3' untranslated regions mediate transcriptional interference between convergent genes both locally and ectopically in S cerevisiae. PLoS Genetics. 10: e1004021. Yang, S., Liu, Y., Jiang, N., Chen, J., Leach, L.J., et al. (2014). Genome-wide eQTLs and heritability for gene expression traits in unrelated individuals. BMC Genomics. 15: 13. Wu, X., Liu, T., Fang, O., Leach, L.J., et al. (2013). miR-194 suppresses metastasis of non-small cell lung cancer through regulating expression of BMP1 and p27(kip1). Oncogene. doi:10.1038/onc.2013.108. Mithani, A., Belfield, E., Brown, C., Jiang, C., Leach, L.J., et al. (2013). HANDS: a tool for genome-wide discovery of subgenome-specific base identity in polyploids. BMC Genomics. 14: 653. Jiang, N., Wang, M., Jia, T., Leach, L.J., et al. (2011). A robust statistical method for association-based eQTL analysis. PLoS One 6(8): e231912. doi:10.1371/journal.pone.0023192. Wang M., Jiang N., Jia T., Leach L.J., Cockram J., Thomas B., Ramsay L., Waugh R. and Luo Z.W. (2011). Genome-wide association mapping of agronomic and morphologic traits in highly structured populations of barley cultivars. Theor. Appl. Genet. doi 10.1007/s00122-011-1697-2. Leach, L.J., Wang, L. Kearsey, M.J. and Luo, Z.W. (2010). Multilocus tetrasomic linkage analysis using Hidden Markov chain model. PNAS. 107: 4270 – 4274. Lu, C., Hu, X., Wang, G., Leach, L.J., et al. (2010). Why do essential proteins tend to be clustered in the yeast interactome network? Molecular Biosystems. doi: 10.1039/b921069e. Wang, M., Hu, X., Li, G., Leach, L.J., Potokina, E., Duka, A., Waugh, R., Kearsey, M.J., Luo, Z. (2009). Robust detection and genotyping of single feature polymorphisms from gene expression data. PLoS Computational Biology. 5(3): e1000317. Jiang, N., Leach, L.J., et al. (2008). Methods for evaluating gene expression from Affymetrix microarray datasets. BMC Bioinformatics. 9:284. Lu, C., Zhang, Z., Leach, L. et al. (2007). Impacts of yeast metabolic network structure on enzyme evolution. Genome Biology. 8:407. Leach, L. J., Zhang, Z., Lu, C.Q., Kearsey, M. J. and Luo, Z. W. (2007). The role of cis regulatory motifs and genetical control of expression in the divergence of yeast duplicate genes. Mol. Biol. Evol. 24(11): 2556-2565. Luo, Z.W., Zhang, Z., Leach, L. et al. (2006). Constructing genetic linkage maps under a tetrasomic model. Genetics. 172: 2635-2645. Hu, X.H., Wang, M.H., Tan, T., Li, J.R., Leach, L. et al. (2006). Genetic dissection of ethanol tolerance in budding yeast S. cerevisiae. Genetics. 175:1479-1487. Wu, X., Liu, T., Fang, O., Leach, L J., Hu. X., and Luo, Z. miR-194 suppresses metastasis of non-small cell lung cancer through regulating expression of BMP1 and p27(kip1). Oncogene . doi:10.1038/onc.2013.108.