Marie Krachler, Anne - University of Birmingham

个人简介

Following completion of an MSc degree in Chemical Engineering at the University of Technology in Vienna, Anne-Marie undertook her PhD research at the University of York as a Marie Curie Early Stage Fellow. Her graduate work under the supervision of Prof. Colin Kleanthous focused on the biochemical and structural characterization of protein-protein complexes involved in maintaining integrity of the cell envelope of Gram-negative bacteria. As a postdoctoral research fellow at UT Southwestern Medical Center in Dallas, Anne-Marie studied the activity of virulence factors from pathogenic bacteria and discovered and entirely new family of proteins involved in host-pathogen interactions

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Hawley CA, Watson CA, Orth K, Krachler AM (2013). A MAM7 peptide-based inhibitor of Staphylococcus aureus adhesion does not interfere with in vitro host cell function. PLoS One. 8(11):e81216. Altura MA, Heath-Heckman EAC, Gillette A, Kremer N, Krachler AM, Brennan C, Ruby EG, Orth K, McFall-Ngai MJ (2013). The first engagement of partners in the Euprymna scolopes-Vibrio ischeri sumbiosis is a two-step process initiated by a few environmental symbiont cells. Env Microbiol. doi: 10.1111/1462-2920.12179. Krachler AM and Orth K (2013). Made to Stick: Anti-Adhesion Therapy for Bacterial Infections. ASM Microbe. July 2013. Krachler AM and Orth K (2013). Targeting the bacteria-host interface: Strategies in anti-adhesion therapy. Virulence. 4(4):284-94. Krachler AM, Mende K, Murray C and Orth K (2012). In vitro characterization of Multivalent Adhesion Molecule 7-based inhibition of multidrug-resistant bacteria isolated from wounded military personnel. Virulence. 3(4):389-99. Zhang L, Krachler AM, Broberg CA, Li Y, Mirzaei H, Gilpin CJ, Orth K (2012). Type III effector VopC mediates invasion for Vibrio species. Cell Rep. 1(5):453-60. Krachler AM and Orth K (2012). Use of the bacterial Multivalent Adhesion Molecule 7 as an antimicrobial agent. Virulence. 3(1):68-71. (Article featured on the cover). Krachler AM, Woolery AR, Orth K (2011). Manipulation of host kinase signalling pathways by bacterial pathogens. J Cell Biol. 195(7):1083-92. Krachler AM, Orth K (2011). Functional characterization of the interaction between the bacterial adhesin Multivalent Adhesion Molecule (MAM) 7 and its host cell ligands. J Biol Chem. 286(45):38939-47. Krachler AM, Ham H, Orth K (2011). Outer membrane adhesion factor multivalent adhesion molecule 7 initiates host cell binding by Gram-negative pathogens. Proc Natl Acad Sci U S A. 108(28):11614-9. (Article highlighted in Nature 2011, 475:9 and in Nature Rev Microbiol 2011, 9(9):627). Orth K, Ham H, Krachler AM (2011). Modulating bacterial MAM polypeptides in pathogenic disease. WO Patent 2,012,138,570. Krachler AM and Orth K (2010). Black Spot, Black Death, Black Pearl: Tales of Bacterial Effectors. Book Chapter in Avancées et nouvelles technologies en Toxinologie – Advances and new technologies in Toxinology (SFET, ed.). ISSN 1760 – 6004