Huber, Damon - University of Birmingham

个人简介

Damon attended Iowa State University from 1996 to 2000 where he majored in Microbiology and minored in Chemistry and Music. As a student, he worked in the lab of Greg Phillips, who piqued Damon’s interest in bacterial genetics. After graduating with his Bachelor’s of Science in 2000, he attended Harvard University where he studied bacterial genetics with Jon Beckwith at Harvard Medical School. During his time in Dr Beckwith’s lab, Damon developed a fascination for the connection between protein folding and the transport of proteins across biological membranes, and he was awarded a PhD for his work on these subjects in 2006. He subsequently moved to Bernd Bukau’s lab at the University of Heidelberg in Germany, where he was an Alexander von Humboldt Fellow. While in Dr Bukau’s group, he discovered a novel pathway for the cotranslational recognition of substrate proteins by the Sec translocation pathway. In 2012, Damon was selected for a Birmingham Fellowship, and he moved into the newly created Institute for Microbiology and Infection at the University of Birmingham in 2013

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Oh E, Becker AH, Sandikci A, Huber D, Chaba R, Gloge F, Nichols RJ, Typas A, Gross CA, Kramer G, Weissman JS, Bukau B. (2011) Selective ribosome profiling reveals the cotranslational chaperone action of Trigger Factor in vivo. Cell. 147:1295-308. Huber D, Rajagopalan N, Preissler S, Rocco MA, Merz F, Kramer G, and Bukau B. (2011) SecA interacts with ribosomes in order to facilitate posttranslational translocation in bacteria. Mol Cell. 41:343-53 Mogk A, Huber D, and Bukau B. (2011) Integrating Protein Homeostasis Strategies in Prokaryotes. Cold Spring Harb Perspect Biol. 3(4). pii: a004366. doi: 10.1101/cshperspect.a004366 Huber D, Chaffotte A, Eser M, Planson A, and Beckwith J. (2010) Amino acid residues important for folding of thioredoxin are revealed only by study of the physiologically relevant reduced form of the protein. Biochemistry. 49:8922-8 Huber D and Bukau B. (2008) DegP: A Protein Death Star. Structure. 16:989-90 Desvaux M, Scott-Tucker A, Turner SM, Cooper LM, Huber D, Nataro JP, Henderson IR. (2007) A conserved extended signal peptide region directs posttranslational protein translocation via a novel mechanism. Microbiology. 153:59-70 Huber D and Beckwith J. (2006) Phage Display extends its reach. Nat Biotechnol. 24:793-4 Huber D, Cha M, Debarbieux L, Planson AG, Cruz N, López G, Tasayco ML, Chaffotte A, and Beckwith J. (2005) A selection for mutants that interfere with folding of E. coli thioredoxin-1 in vivo. Proc Natl Acad Sci USA. 102:18872-7 Huber D, Boyd D, Xia Y, Olma MH, Gerstein M, Beckwith J. (2005) Use of thioredoxin as a reporter to identify a subset of Escherichia coli signal sequences that promote signal recognition particle-dependent translocation. J Bacteriol. 187:2983-91 Schierle CF, Berkmen M, Huber DR, Kumamoto C, Boyd D, Beckwith J. (2003) The DsbA signal sequence directs efficient, co-translational export of passenger proteins to the E. coli periplasm via the SRP pathway. J Bacteriol. 185:5706-13 Leeds JA, Boyd D, Huber DR, Sonoda GK, Luu HT, Engelman DM, Beckwith J. (2001) Genetic selection for and molecular dynamic modeling of a protein transmembrane domain multimerization motif from a random Escherichia coli genomic library. J Mol Biol. 313:181-95 Phillips GJ, Park SK, and Huber D. (2000) High copy number plasmids compatible with commonly used cloning vectors. Biotechniques. 28: 400-402, 404, 406