Hotchin, Neil - University of Birmingham

个人简介

Dr Neil Hotchin was born in Lincolnshire and did his first degree in Biology at the University of York. His PhD at the Royal Postgraduate Medical School (now part of Imperial College) was on the role of Epstein Barr Virus in the development of Burkitt’s Lymphoma. After his PhD he worked as a postdoctoral Research Fellow at the Imperial Research Cancer Research Fund (now the Cancer Research UK London Research Institute) where he first became interested in how cell adhesion to extracellular matrix regulates cell function. He continued this work in the MRC Laboratory for Molecular Cell Biology at University College London before moving to Birmingham to set up his own research group

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Clarke K, Daubon T, Turan N, Soulet F, Zahari MM, Ryan KR, Durant S, He S, Herbert J, Ankers J, Heath JK, Bjerkvig R, Bicknell R, Hotchin NA*, Bikfalvi A*, Falciani F*. (2015). Inference of Low and High-Grade Glioma Gene Regulatory Networks Delineates the Role of Rnd3 in Establishing Multiple Hallmarks of Cancer. PLOS Genet. 11, e1005325 (* joint senior authors) Scales TM, Jayo A, Obara B, Holt MR, Hotchin NA, Berditchevski F and Parsons M (2013). a3b1 integrins regulate CD151 complex assembly and membrane dynamics in carcinoma cells within 3D environments. Oncogene 32, 3965-3979. Lim J, Thompson J, May RC, Hotchin NA and Caron E. (2013). Regulator of G-Protein Signalling-14 (RGS-14) regulates the activation of aMb2 integrin during phagocytosis. PLOS ONE 8, e69163. Lock FE, Ryan KR, Poulter NS, Parsons M, Hotchin NA (2012) Differential Regulation of Adhesion Complex Turnover by ROCK1 and ROCK2. PLOS ONE 7, e31423. Ryan KR, Lock FE, Heath JK, Hotchin NA. (2012). Plakoglobin-dependent regulation of keratinocyte apoptosis by Rnd3. J. Cell Sci. 125, 3202-3209. Lim J and Hotchin NA (2012). Signalling mechanisms of the leukocyte integrin aMb2: Current and future perspectives. Biol. Cell 104, 631-640. Lim J, Hotchin NA, Caron E (2011). Ser756 of β2 integrin controls Rap1 activity during inside-out activation of αMβ2. Biochem. J. 437, 461-467. Lock FE and Hotchin NA (2009). Distinct roles for ROCK1 and ROCK2 in the regulation of keratinocyte differentiation. PLOS ONE 4, e8190. Brookes MJ, Boult J, Roberts K, Cooper BT, Hotchin NA, Matthews G, Iqbal T, Tselepis C (2008). A role for iron in Wnt signaling. Oncogene 27, 966-975. Turner FE, Broad S, Khanim FL, Jeanes A, Talma S, Hughes S, Tselepis C, Hotchin NA (2006). Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes. J. Biol. Chem. 281, 21321-21331. Latysheva N, Muratov G, Rajesh S, Padgett M, Hotchin NA, Overduin M, Berditchevski F (2006). Syntenin-1 is a new component of tetraspanin-enriched microdomains: mechanisms and consequences of the interaction of syntenin-1 with CD63. Mol.Cell Biol. 20, 7707-7718. Sawada S,Yoshimoto M, Odintsova E, Hotchin NA and Berditchevski F (2003). The tetraspanin CD151 functions as a negative regulator in the adhesion-dependent activation of Ras. J. Biol. Chem. 278, 26323-26326. McMullan R, Lax S, Robertson VH, Radford DR, Broad S, Watt FM, Rowles A, Croft DR, Olson MF and Hotchin NA (2003). Keratinocyte differentiation is regulated by the Rho and ROCK signaling pathway. Curr. Biol.13, 2185-2189. Akhtar N and Hotchin NA (2001). RAC1 regulates adherens junctions through endocytosis of E-cadherin. Mol. Biol. Cell 12, 847-862. Hotchin NA, Cover TL and Akhtar N (2000). Cell vacuolation induced by the VacA cytotoxin of Helicobacter pylori is regulated by the Rac1 GTPase. J. Biol. Chem. 275, 14009-14012.