Grainger, David - University of Birmingham

个人简介

David’s first degree (Biochemistry) was awarded by the University of Birmingham in 1999. Following this, David trained as a teacher at the University of Wolverhampton (2000). Keen to reengage with the cutting edge research that he had been exposed to as an undergraduate, David returned to Birmingham to complete his PhD studies (2004). Employment as a post-doctoral research associate followed. During this time David developed the use of high-throughput techniques to map gene regulatory events in bacteria. In 2008 David was awarded a prestigious Career Development Fellowship by the Wellcome Trust and used this grant to set up his research group at the University of Warwick. During this time David established collaborations with biophysical scientists and began studying DNA and its interactions at the single-molecule level.

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Singh SS, Singh N, Bonocora RP, Fitzgerald DM, Wade JT, Grainger DC (2014) Widespread suppression of intragenic transcription initiation by H-NS. Genes Dev. (advanced access) Singh SS and Grainger DC (2013) H-NS Can Facilitate Specific DNA-binding by RNA Polymerase in AT-rich Gene Regulatory Regions. PLoS Genet. 9(6):e1003589 Chintakayala K, Singh SS, Rossiter AE, Shahapure R, Dame RT, Grainger DC (2013) E. coli Fis Protein Insulates the cbpA Gene from Uncontrolled Transcription. PLoS Genet. 9(1): e1003152. Dame RT, Kalmykowa OJ, Grainger DC (2011) Chromosomal macro-domains and associated proteins: implications for DNA organization and replication in Gram negative bacteria. PLoS Genet. 7(6): e1002123.