Fan, Yun - University of Birmingham - School of Biosciences

个人简介

Dr Fan was initially trained as a molecular biologist in China. He then completed his PhD in the field of Neurobiology in Switzerland. He subsequently worked at the University of Texas MD Anderson Cancer Center and the University of Massachusetts Medical School in the United States during which time his research focused on regulation of program cell death (apoptosis) and its related compensatory cell proliferation.

近期论文

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Li M., Lindblad J.L., Perez E., Bergmann A. and Fan Y. (2016). Autophagy-independent function of Atg1 for apoptosis-induced compensatory proliferation. BMC Biol. 14:70. Fogarty C.E., Diwanji N., Lindblad J.L., Tare M., Amcheslavsky A., Makhijani K., Brückner K., Fan Y. and Bergmann A. (2016). Extracellular Reactive Oxygen Species Drive Apoptosis-Induced Proliferation via Drosophila Macrophages. Curr Biol 26(5): 575-584. Fan Y* and Bergmann A* (2014). Multiple mechanisms modulate distinct cellular susceptibilities towards apoptosis in the developing Drosophila eye. Dev Cell 30(1):48-60.(*corresponding authors) http://www.ncbi.nlm.nih.gov/pubmed/24981611 Fan Y*, Wang S, Hernandez J, Yenigun VB, Hertlein G, Fogarty CE, Lindblad JL and Bergmann A* (2014). Genetic models of apoptosis-induced proliferation decipher activation of JNK and identify a requirement of EGFR signaling for tissue regenerative responses in Drosophila. PLoS Genetics 10(1): e1004131.(*corresponding authors) http://www.ncbi.nlm.nih.gov/pubmed/24497843 Huang Q, Tang X, Wang G, Fan Y, Ray L, Bergmann A, Belenkaya TY, Ling X, Yan D, Lin Y, Ye X, Shi W, Zhou X, Lu F, Qu J and Lin X (2014). Ubr3 E3 ligase regulates apoptosis by controlling the activity of DIAP1 in Drosophila. Cell Death Differ 21(12):1961-70.http://www.ncbi.nlm.nih.gov/pubmed/25146930 Christiansen AE, Ding T, Fan Y, Graves HK, Herz HM, Lindblad JL and Bergmann A (2012). Non-cell autonomous control of apoptosis by ligand-dependent Hedgehog signaling in Drosophila. Cell Death Differ20(2):302-11.http://www.ncbi.nlm.nih.gov/pubmed/23018595 Lee TV*, Fan Y*, Wang S, Srivastava M, Broemer M, Meier P and Bergmann A (2011). Drosophila IAP1-mediated ubiquitylation controls processing, but not protein stability, of the initiator caspase DRONC. PLoS Genetics7 (9): e1002261.(*co-first authors) http://www.ncbi.nlm.nih.gov/pubmed/21909282 Fan Y, Lee T, Xu D, Chen Z, Lamblin AF, Steller H and Bergmann A (2010). Dual roles of Drosophila p53 in cell death and cell differentiation. Cell Death Differ17 (6): 912-921.http://www.ncbi.nlm.nih.gov/pubmed/19960025 Fan Y and Bergmann A (2010). The cleaved-Caspase-3 antibody is a marker of Caspase-9-like DRONC activity in Drosophila. Cell Death Differ17 (3), 534-539.http://www.ncbi.nlm.nih.gov/pubmed/19960024 Xu D, Woodfield SE, Lee TV, Fan Y, Antonio C and Bergmann A (2009). Genetic control of programmed cell death (apoptosis) in Drosophila. Fly (Austin) 3(1):78-90.http://www.ncbi.nlm.nih.gov/pubmed/19182545 Fan Y and Bergmann A (2008). Apoptosis-induced compensatory proliferation. The Cell is dead. Long live the Cell! Trends Cell Biol18 (10), 467-473.http://www.ncbi.nlm.nih.gov/pubmed/18774295 Fan Y and Bergmann A (2008). Distinct mechanisms of apoptosis-induced compensatory proliferation in proliferating and differentiating tissues in the Drosophila eye. Dev Cell14 (3), 339-410. (evaluated by Faculty of 1000 Biology as “Must Read”)http://www.ncbi.nlm.nih.gov/pubmed/18331718