Dafforn, Tim - University of Birmingham

个人简介

I began my science career studying protein engineering under Professor J. John Holbrook at the Bristol University

近期论文

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Berwick MR, Lewis DJ, Jones AW, Parslow RA, Dafforn TR, Cooper HJ, Wilkie J, Pikramenou Z, Britton MM, Peacock AF. De Novo Design of Ln(III) Coiled Coils for Imaging Applications. J Am Chem Soc. 2014 Jan 16. Brown I, Dafforn TR, Fryer PJ, Cox PW Kinetic study of the thermal denaturation of a hyperthermostable extracellular α-amylase from Pyrococcus furiosus. Biochim Biophys Acta. 2013 Dec;1834(12):2600-5. Bonander N, Jamshad M, Oberthür D, Clare M, Barwell J, Hu K, Farquhar MJ, Stamataki Z, Harris HJ, Dierks K, Dafforn TR, Betzel C, McKeating JA, Bill RM Production, purification and characterization of recombinant, full-length human claudin-1. PLoS One. 2013 May 21;8(5):e64517 Abdul-Wahab MF, Homma T, Wright M, Olerenshaw D, Dafforn TR, Nagata K, Miller AD. The pH sensitivity of murine heat shock protein 47 (HSP47) binding to collagen is affected by mutations in the breach histidine cluster. J Biol Chem. 2013 Feb 8;288(6):4452-61. Pacheco-Gómez R, Cheng X, Hicks MR, Smith CJ, Roper DI, Addinall S, Rodger A, Dafforn TR. Tetramerization of ZapA is required for FtsZ bundling. Biochem J. 2013 Feb 1;449(3):795-802. Hicks, M.R., A. Rodger, Y.P. Lin, N.C. Jones, S.V. Hoffmann, and T.R. Dafforn, Rapid Injection linear dichroism for studying the kinetics of biological processes. Analytical Chemistry, 2012. In Press. McNab, G.L., T.R. Dafforn, A. Wood, E. Sapey, and R.A. Stockley, A novel model and molecular therapy for Z alpha-1 antitrypsin deficiency. Mammalian genome : official journal of the International Mammalian Genome Society, 2012. 23(3-4): p. 241-9. Pacheco-Gomez, R., J. Kraemer, S. Stokoe, H.J. England, C.W. Penn, E. Stanley, A. Rodger, J. Ward, M.R. Hicks, and T.R. Dafforn, Detection of Pathogenic Bacteria Using a Homogeneous Immunoassay Based on Shear Alignment of Virus Particles and Linear Dichroism. Analytical Chemistry, 2012. 84(1): p. 91-97. Turner, D.J., I. Portman, T.R. Dafforn, A. Rodger, D.I. Roper, C.J. Smith, and M.S. Turner, The Mechanics of FtsZ Fibers. Biophysical Journal, 2012. 102(4): p. 731-8. Jamshad, M., Y.P. Lin, T.J. Knowles, R.A. Parslow, C. Harris, M. Wheatley, D.R. Poyner, R.M. Bill, O.R.T. Thomas, M. Overduin, and T.R. Dafforn, Surfactant-free purification of membrane proteins with intact native membrane environment. Biochemical Society Transactions, 2011. 39: p. 813-818. Kosmoliaptsis, V., T.R. Dafforn, A.N. Chaudhry, D.J. Halsall, J.A. Bradley, and C.J. Taylor, High Resolution Three-Dimensional Modelling of Hla Class I Structure and Surface Electrostatic Potential Reveals the Molecular Basis for Alloantibody Binding Epitopes. Transplant International, 2011. 24: p. 89-89. Kosmoliaptsis, V., T.R. Dafforn, A.N. Chaudhry, D.J. Halsall, J.A. Bradley, and C.J. Taylor, High-resolution, three-dimensional modeling of human leukocyte antigen class I structure and surface electrostatic potential reveals the molecular basis for alloantibody binding epitopes. Human Immunology, 2011. 72(11): p. 1049-1059. Pacheco-Gomez, R., D.I. Roper, T.R. Dafforn, and A. Rodger, The pH Dependence of Polymerization and Bundling by the Essential Bacterial Cytoskeltal Protein FtsZ. Plos One, 2011. 6(6). Bromley, E.H.C., K.J. Channon, P.J.S. King, Z.N. Mahmoud, E.F. Banwell, M.F. Butler, M.P. Crump, T.R. Dafforn, M.R. Hicks, J.D. Hirst, A. Rodger, and D.N. Woolfson, Assembly Pathway of a Designed alpha-Helical Protein Fiber. Biophysical Journal, 2010. 98(8): p. 1668-1676. Damianoglou, A., A. Rodger, C. Pridmore, T.R. Dafforn, J.A. Mosely, J.M. Sanderson, and M.R. Hicks, The Synergistic Action of Melittin and Phospholipase A2 with Lipid Membranes: Development of Linear Dichroism for Membrane-Insertion Kinetics. Protein and Peptide Letters, 2010. 17(11): p. 1351-1362. Kosmoliaptsis, V., A.N. Chaudhry, L.D. Sharples, D.J. Halsall, T.R. Dafforn, J.A. Bradley, and C.J. Taylor, Structural and Physiochemical Computer Modelling of HLA Class II Predicts the Occurrence and Magnitude of Humoral Immune Responses to Alloantigen. American Journal of Transplantation, 2010. 10: p. 45-45. Mardakheh, F.K., G. Auciello, T.R. Dafforn, J.Z. Rappoport, and J.K. Heath, Nbr1 Is a Novel Inhibitor of Ligand-Mediated Receptor Tyrosine Kinase Degradation. Molecular and Cellular Biology, 2010. 30(24): p. 5672-5685. Marshall, K.E., M.R. Hicks, T.L. Williams, S.V. Hoffmann, A. Rodger, T.R. Dafforn, and L.C. Serpell, Characterizing the Assembly of the Sup35 Yeast Prion Fragment, GNNQQNY: Structural Changes Accompany a Fiber-to-Crystal Switch. Biophysical Journal, 2010. 98(2): p. 330-338.