Bhatt, Apoorva - University of Birmingham

个人简介

2011-Present: Lecturer in Molecular Microbiology 2006-2011: Medical Research Council Fellow (Career Development Award) 2002-2006: Research Associate, Howard Hughes Medical Institute, Albert Einstein College of Medicine 2000-2002: Research Associate, University of Cambridge 1996-2000: PhD, John Innes Centre, Norwich

近期论文

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Ly D., Kasmar A.G., Cheng T.Y., de Jong A., Huang S., Roy S., Bhatt A., van Summeren R.P., Altman J.D., Jacobs W.R. Jr, Adams E.J., Minnaard A.J., Porcelli S.A. and Moody D.B. (2013) CD1c tetramers detect ex vivo T cell responses to processed phosphomycoketide antigens. J Exp Med 2013 210:729-741. Varela C., Rittmann D., Singh A., Krumbach K., Bhatt K., Eggeling L., Besra G.S. and Bhatt A. (2012) MmpL genes are associated with mycolic acid metabolism in mycobacteria and corynebacteria. Chem Biol 19:498-506. Yamada H., Bhatt A., Danev R., Fujiwara N., Maeda S., Mitarai S., Chikamatsu K., Aono A., Nitta K., Jacobs WR Jr. and Nagayama K. (2012) Non-acid-fastness in Mycobacterium tuberculosis ΔkasB mutant correlates with the cell envelope electron density. Tuberculosis 92:351-357. Sarkar D., Sidhu M., Singh A., Chen J., Lammas D.A., van der Sar A.M., Besra G.S. and Bhatt A. (2011) Identification of a glycosyltransferase from Mycobacterium marinum involved in the addition of a caryophyllose moiety in lipooligosaccharides. J Bacteriol 193:2336-2340. Alderwick L.J., Lloyd G.S., Ghadbane H., May J.W., Bhatt A., Eggeling L., Fütterer K., and Besra G.S. (2011) The C-terminal domain of the Arabinosyltransferase Mycobacterium tuberculosis EmbC is a lectin-like carbohydrate binding module. PLoS Pathog 7(2):e1001299. Khan S., Nagarajan N.S., Parikh A., Samantaray S., Singh A., Kumar D., Roy R.P., Bhatt A. and Nandicoori V.K. (2010) Phosphorylation of enoyl-ACP reductase InhA impacts mycobacterial growth and survival. J Biol Chem 285: 37860-37871. Taylor R.C., Brown A.K., Singh A., Bhatt A. and Besra G.S. (2010) Characterization of a beta-hydroxybutyryl-CoA dehydrogenase from Mycobacterium tuberculosis. Microbiol 156: 1975-1982. Birch H.L., Alderwick L.J., Appelmelk B.J., Maaskant J., Bhatt A., Singh A., Nigou J., Eggeling L., Geurtsen J. and Besra G.S. (2010) A truncated lipoglycan from mycobacteria with altered immunological properties. Proc Natl Acad Sci 107: 2634-2639. Chen J., Kriakov J., Singh A., Jacobs Jr. W.R., Besra G.S. and Bhatt A. (2009) Defects in glycopeptidolipid biosynthesis confer phage I3 resistance in Mycobacterium smegmatis Microbiol 155: 4050-4057. Brown A.K., Taylor R.C., Bhatt A., Fütterer K. and Besra G.S. (2009) Platensimycin activity against mycobacterial b-ketoacyl-ACP synthases. PLoS ONE 17: e6306. Bhatt A., Brown A.K., Singh A., Minnkin D.E. and Besra G.S. (2008) Loss of a mycobacterial gene encoding a reductase leads to an altered cell wall containing b-oxo-mycolic acid analogs and accumulation of ketones. Chem Biol 15: 930-939. Bhatt A. and Jacobs Jr. W.R. (2008) Testing gene essentiality in mycobacteria using specialized transduction and inducible promoters. Mycobacteria Protocols, 2nd Ed, Humana Press. Ed. Tanya Parish and Amanda Brown. Bhowruth V., Alderwick L.J., Brown A.K., Bhatt A. and Besra G.S. (2008) Tuberculosis: a balanced diet of lipids and carbohydrates. Biochem Soc Trans 36: 555–565. Birch H.L., Alderwick L.J., Bhatt A., Rittman D., Krumbach K., Singh A., Yu B., Lowary T.L., Eggeling L. and Besra G.S. (2008) Biosynthesis of mycobacterial arabinogalactan: identification of a novel ?(1→3) arabinofuranosyltransferase. Mol Microbiol 65: 1191-1206. Mishra A.K., Alderwick L.J., Rittman D., Wang C., Bhatt A., Jacobs Jr. W.R., Takayama K., Eggeling L. and Besra G.S. (2008) Identification of a novel a(1→6) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505 affords a lipomannan- and lipoarabinomannan-deficient mutant. Mol Microbiol 68: 1595-1613. Dover L.G., Bhatt A., Bhowruth V., Willcox B.E. and Besra G.S. (2008) New drugs and vaccines for drug-resistant Mycobacterium tuberculosis infections. Expert Rev Vaccines 7: 481-497 Bhatt A./Brown A.K?., Singh A., Saparia E., Evans A.F. and Besra G.S. (2007) Identification of the dehydratase component of the mycobacterial mycolic acid synthesizing fatty acid synthase-II complex. Microbiol 153: 4166-4173.[ ? Equal authorship]. Brown A.K., Papaemmanouil A., Bhowruth V., Bhatt A., Dover L.G. and Besra G.S. (2007) Flavonoid inhibitors as novel antimycobacterial agents targeting Rv0636, a putative dehydratase enzyme involved in Mycobacterium tuberculosis fatty acid synthase II. Microbiol 153: 3314-3322. Bhatt A., Molle V., Besra G.S., Jacobs Jr. W.R. and Kremer L. (2007) The Mycobacterium tuberculosis FAS-II condensing enzymes: their role in mycolic acid biosynthesis, acid fastness, pathogenesis and in drug development. Mol Microbiol64: 1442-1454. Bhatt A., Fujiwara N., Bhatt K., Gurcha S.S., Kremer L., Chen B., Chan J., Porcelli S., Kobayashi K., Besra G.S. and Jacobs Jr. W.R. (2007) Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice. Proc Natl Acad Sci (USA) 104: 5157-5162.