Wynn, Richard - UT Southwestern Medical Center

个人简介

Education Graduate School Texas Tech University (1983) Graduate School Texas Tech University (1986) Honors & Awards Distinguished Alumni Distinguished Alumni at McMurry University, Abilene, Texas (2014-2015)

研究领域

Research Interest Cancer Diabetes and Glucose metabolism Heat shock and chaperone proteins Inborn errors of metabolism Structure and function of mitochondrial multienzyme complexes

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Benzothiophene Carboxylate Derivatives as Novel Allosteric Inhibitors of Branched-chain a-Ketoacid Dehydrogenase Kinase. Tso SC, Gui WJ, Wu CY, Chuang JL, Qi X, Skvorak KJ, Dorko K, Wallace AL, Morlock LK, Lee BH, Hutson SM, Strom SC, Williams NS, Tambar UK, Wynn RM, Chuang DT J. Biol. Chem. 2014 Jun Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket. Tso SC, Qi X, Gui WJ, Wu CY, Chuang JL, Wernstedt-Asterholm I, Morlock LK, Owens KR, Scherer PE, Williams NS, Tambar UK, Wynn RM, Chuang DT J. Biol. Chem. 2014 Feb 289 7 4432-43 Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain a-ketoacid dehydrogenase kinase. Tso SC, Qi X, Gui WJ, Chuang JL, Morlock LK, Wallace AL, Ahmed K, Laxman S, Campeau PM, Lee BH, Hutson SM, Tu BP, Williams NS, Tambar UK, Wynn RM, Chuang DT Proc. Natl. Acad. Sci. U.S.A. 2013 May Structural and Thermodynamic Basis for Weak Interactions between Dihydrolipoamide Dehydrogenase and Subunit-binding Domain of the Branched-chain {alpha}-Ketoacid Dehydrogenase Complex. Brautigam CA, Wynn RM, Chuang JL, Naik MT, Young BB, Huang TH, Chuang DT J. Biol. Chem. 2011 Jul 286 26 23476-88 Phenylbutyrate therapy for maple syrup urine disease. Brunetti-Pierri N, Lanpher B, Erez A, Ananieva EA, Islam M, Marini JC, Sun Q, Yu C, Hegde M, Li J, Wynn RM, Chuang DT, Hutson S, Lee B Hum. Mol. Genet. 2011 Feb 20 4 631-40 Determination of protein complex stoichiometry through multisignal sedimentation velocity experiments. Padrick SB, Deka RK, Chuang JL, Wynn RM, Chuang DT, Norgard MV, Rosen MK, Brautigam CA Anal. Biochem. 2010 Dec 407 1 89-103 Subunit and catalytic component stoichiometries of an in vitro reconstituted human pyruvate dehydrogenase complex Brautigam, C.A. Wynn, R.M., Chuang, J.L. and Chuang, D.T. J. Biol Chem. Winter 2009 284 13086-13098 Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity Wynn, R.M., Kato, M., Chuang, J.L., Tso, S.C., Li, J. and Chuang, D.T. J. Biol. Chem. July 2008 283 25305-25315 The two active sites in human branched-chain alpha-keto acid dehydrogenase operate independently without an obligatory alternating-site mechanism. Li J, Machius M, Chuang JL, Wynn RM, Chuang DT J. Biol. Chem. 2007 Apr 282 16 11904-13 Determination of Protein Complex Stoichiometry Though Multisignal Sedimentation Velocity Experiments. Anal Biochem. Jul 24. [Epub ahead of print] PMID: 20667444. Padrick, S.B., Deka, R.K., Chuang, J.L., Wynn, R.M., Chuang, D.T., Norgard, M.V., Rosen, M.K. and Brautigam, C.A. Metabolite regulation of nucleo-cytosolic trafficking of carbohydrate response element binding protein (ChREBP): role of ketone bodies. Nakagawa T, Ge Q, Powlosky R, Wynn RM, Veech RL, Uyeda K J. Biol. Chem. 2013 Aug Structure-based Development of a Robust Novel Inhibitor for Mitochondrial Branched-chain α-Ketoacid Dehydrogenase Kinase. Shih-Chia Tso, Xiangbing Qi, Wen-Jun Gui, Jacinta L. Chuang, Lorraine K. Morlock, Amy L. Wallace, Kamran Ahmed, Sunil Laxman, Philippe M. Campeau, Brendan H. Lee, Susan M. Hutson, Benjamin P. Tu, Noelle S. Williams, Uttam K.Tambar, R. Max Wynn, and David T. Chuang. PNAS 2013 Structural characterization of a unique interface between carbohydrate response element-binding protein (ChREBP) and 14-3-3ß protein. Ge Q, Huang N, Wynn RM, Li Y, Du X, Miller B, Zhang H, Uyeda K J. Biol. Chem. 2012 Dec 287 50 41914-21 Structural and biochemical characterization of human mitochondrial branched-chain a-ketoacid dehydrogenase phosphatase. Wynn RM, Li J, Brautigam CA, Chuang JL, Chuang DT J. Biol. Chem. 2012 Mar 287 12 9178-92 Structural and Biochemical Characterization of Human Mitochondrial Branched-chain a-Ketoacid Dehydrogenase Phosphatase. Wynn, R.M., Jun Li, Chad A. Brautigam, Jacinta L. Chuang, and David T. Chuang JBC 2012 287 9178-92 Structural characterization of a unique interface between Carbohydrate Response Element Binding Protein (ChREBP) and 14-3-3ß Qiang Ge, Niang Huang, R. Max Wynn, Yang Li, Xinlin Du, Bonnie Miller, Hong Zhang and Kosaku Uyeda JBC 2012 287 41914-21 Importin {alpha} binding to a nuclear localization signal of carbohydrate response element-binding protein (ChREBP). Ge Q, Nakagawa T, Wynn RM, Chook YM, Miller BC, Uyeda K The Journal of biological chemistry 2011 Jun 28119-27 Coordinate regulation/localization of the carbohydrate responsive binding protein (ChREBP) by two nuclear export signal sites: discovery of a new leucine-rich nuclear export signal site. Fukasawa M, Ge Q, Wynn RM, Ishii S, Uyeda K Biochem. Biophys. Res. Commun. 2010 Jan 391 2 1166-9 Branched-chain amino acid metabolon: interaction of glutamate dehydrogenase with the mitochondrial branched-chain aminotransferase (BCATm). Islam MM, Nautiyal M, Wynn RM, Mobley JA, Chuang DT, Hutson SM J. Biol. Chem. 2010 Jan 285 1 265-76 Subunit and catalytic component stoichiometries of an in vitro reconstituted human pyruvate dehydrogenase complex. Brautigam CA, Wynn RM, Chuang JL, Chuang DT J. Biol. Chem. 2009 May 284 19 13086-98