Peacock, Anna - University of Birmingham

个人简介

Anna Peacock qualified with a MChem (Hons) in Chemistry from the University of York in 2003. She performed her dissertation with Professor Robin N. Perutz and Dr Anne-Kathrin Duhme-Klair on the development of a metal-based lumophore tailored to sense biologically relevant oxometalates. She then went on to study for a PhD with Professor Peter J. Sadler FRS at the University of Edinburgh on the design of osmium(II) arene anticancer complexes. This work resulted in a patent application being filed by the University of Edinburgh. In 2007 Anna moved to a post-doctoral position at the University of Michigan with Professor Vincent L Pecoraro to work on the de novo design of metallopeptides. In 2009 Anna took up her first academic post as a Lecturer in the School of Chemistry here at the University of Birmingham

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Berwick, M. R.; Lewis, D. J.; Pikramenou, Z.; Jones, A. W.; Cooper, H. J.; Wilkie, J.; Britton, M. M.; Peacock, A. F. A.* (2014) “De Novo Design of Ln(III) Coiled Coils for Imaging Applications” Journal of the American Chemical Society, 136, 1166-1169. Oheix, E.; Peacock, A. F. A.* (2014) “Metal-ion-regulated miniature dna-binding proteins based on GCN4 and non-native regulation sites” Chemistry a European Journal,20, 2829-2839. Peacock, A. F. A.*(2013) “Incorporating metals into de novo proteins” Current Opinion in Chemical Biology, 17, 934-939.Invited contribution Special Edition. Eds D. N. Woolfson, S.-C. Hung. Oakley, M. T.*; Oheix, E.; Peacock, A. F. A.*; Johnston, R. L.* (2013) “Computational and Experimental Investigations into the Conformations of Cyclic Tetra-α/β-Peptides” The Journal of Physical Chemistry B, 117, 8122-8134. Oheix, E.; Spencer, N.; Gethings, L. A.; Peacock, A. F. A.* (2013) “Conformational study of an artificial metal-dependent regulation site for use in designer proteins” Zeitschrift für Anorganische und Allgemeine Chemie, 639, 1370-1383. Invited contribution Special Edition. Eds J. Reedijk, B. Krebs. Peacock, A. F. A*; Bullen, G. A.; Gethings, L.; Williams, J. P.; Kriel, F. H.; Coates, J. (2012) “Gold-Phosphine Binding to De Novo Designed Coiled Coil Peptides”, Journal of Inorganic Biochemistry, 117, 298-305. Invited contribution Special Edition. Eds M. Capdevila, J. M. Dominguez-Vera, S. Atrian and ò. Palacios. Zastrow, M.; Peacock, A. F. A.; Stuckey, J.; Pecoraro, V. L. (2012) “Hydrolytic Catalysis and Structural Stabilization in a Designed Metalloprotein” Nature Chemistry, 4, 118-123 4, 118-123. Chakraborty, S.; Touw, D. S.; Peacock, A. F. A.; Stuckey, J. A.; Pecoraro, V. L. (2010) "Structural Comparisons of Apo- and Metallated Three Stranded Coiled Coils Clarify Metal Binding Determinants in Thiolate Containing Designed Peptides", Journal of the American Chemical Society, 132, 13240-13250.. Bergamo, A.; Masi, A.; Peacock, A. F. A.; Habtemariam, A.; Sadler, P. J.; Sava, G. (2010) “In vivo tumour and metastasis reduction and in vitro effects on invasion assays of the ruthenium RM175 and osmium AFAP51 organometallics in the mammary cancer model” Journal of Inorganic Biochemistry, 104, 79-86. Peacock, A. F. A.; Stuckey, J. A.; Pecoraro, V. L. (2009) “Chirally Switching Metal Coordination Environments in Designed Peptides”, Angewandte Chemie International Edition, 48, 7371-7374. Inside Cover. Peacock, A. F. A.; Iranzo, O.; Pecoraro, V. L. (2009) “Harnessing natures ability to control metal ion coordination geometry using de novo designed peptides”, Dalton Transactions, 13, 2271-2280. Cover. Van Rijt, S. H.; Peacock, A. F. A.; Johnstone, R. J. L.; Parsons, S.; Sadler, P. J. (2009) “Organometallic osmium(II) arene anticancer complexes containing picolinate derivatives” Inorganic Chemistry, 48, 1753-1762. Peacock, A. F. A.; Hemmingsen, L.; Pecoraro, V. L. (2008) “Using diastereopeptides to control metal ion coordination in proteins” Proceedings of the National Academy of Science, USA, 105, 16566-16571. Peacock, A. F. A.; Sadler, P. J. (2008) “Medicinal Organometallic Chemistry: Designing Metal Arene Complexes as Anticancer Agents” Chemistry an Asian Journal, 3, 1890-1899. VIP article. Kostrhunova, H.; Florian, J.; Novakova, O.; Peacock, A. F. A.; Sadler, P. J.; Brabec, V. (2008) “DNA interactions of monofunctional organometallic osmium(II) antitumor complexes in cell-free media” Journal of Medicinal Chemistry, 51, 3635-3643. Peacock, A. F. A.; Habtemariam, A.; Moggach, S. A.; Prescimone, A.; Parsons, S.; Sadler, P. J. (2007) “Chloro Half-Sandwich Osmium(II) Complexes: Influence of Chelated N,N-Ligands on Hydrolysis, Guanine Binding and Cytotoxicity” Inorganic Chemistry, 46, 4049-4059. Peacock, A. F. A.; Parsons, S.; Sadler, P. J. (2007) “Tuning the Hydrolytic Chemistry of Osmium Arene Complexes with N,O-Chelating Ligands to Achieve Cancer Cell Cytotoxicity” Journal of the American Chemical Society, 129, 3348-3357., 129, 3348-3357. Peacock, A. F. A.; Melchart, M.; Deeth R. J.; Habtemariam, A.; Parsons, S.; Sadler, P. J. (2007) “Osmium(II) and Ruthenium(II) Arene Maltolato Complexes: Rapid Hydrolysis and Nucleobase Binding” Chemistry a European Journal, 13, 2601-2613. Yan, Y. N.; Melchart, M.; Habtemariam, A.; Peacock, A. F. A.; Sadler, P. J. (2006) “Catalysis of Regioselective Reduction of NAD+ by Ruthenium(II) Arene Complexes Under Biologically-Relevant Conditions” Journal of Biological Inorganic Chemistry, 11, 483-488. Peacock, A. F. A.; Habtemariam, A.; Fernández, R.; Walland, V.; Fabbiani, F. P. A.; Parsons, S.; Aird, R. E.; Jodrell, D. I.; Sadler, P. J. (2006) “Tuning the Reactivity of Osmium(II) and Ruthenium(II) Arene Complexes under Physiological Conditions” Journal of the American Chemical Society, 128, 1739-1748., 128, 1739-1748. Peacock, A. F. A.; Batey, H. D.; Raendler, C.; Whitwood, A. C.; Perutz, R. N.; Duhme-Klair, A.-K. (2005) “A Metal-Based Lumophore Tailored To Sense Biologically Relevant Oxometalates” Angewandte Chemie, International Edition, 44, 1712-1714., 44, 1712-1714.