Wu, Shwu-Yuan - UT Southwestern Medical Center

个人简介

Education Graduate School Yang-Ming Medical College - China (1986), Biochemistry Graduate School University of Rochester (1993), Biochemistry Honors & Awards Postdoctoral Fellow Aaron Diamond Foundation (1995) Elon Huntington Hooker Graduate Fellowship University of Rochester (1993)

研究领域

Research Interest Chromatin and Epigenetics Human Papillomaviruses p53 Tumor Supressor Protein Post-Translational Modifications Transcription and Gene Regulation

近期论文

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Brd4 links chromatin targeting to HPV transcriptional silencing Wu, S.-Y., A.Y. Lee, S.Y. Hou, J.K. Kemper, H. Erdjument-Bromage, P. Tempst, and C.-M. Chiang Genes Dev. 2006 20 2383-2396 Human Mediator enhances activator-facilitated recruitment of RNA polymerase II and promoter recognition by TATA-binding protein (TBP) independently of TBP-associated factors Wu, S.-Y., T. Zhou, and C.-M. Chiang Mol. Cell. Biol. 2003 23 6229-6242 TATA-binding protein-associated factors enhance the recruitment of RNA polymerase II by transcriptional activators Wu, S.-Y. and C.-M. Chiang J. Biol. Chem. 2001 276 34235-34243 Isolation of mouse TFIID and functional characterization of TBP and TFIID in mediating estrogen receptor and chromatin transcription Wu, S.-Y., M.C. Thomas, S.Y. Hou, V. Likhite, and C.-M. Chiang J. Biol. Chem. 1999 274 23480-23490 TAFII-independent activation mediated by human TBP in the presence of the positive cofactor PC4 Wu, S.-Y., E. Kershnar, and C.-M. Chiang EMBO J. 1998 17 4478-4490 The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation Wu, S.-Y. and C.-M. Chiang J. Biol. Chem. 2007 282 13141-13145 CTCF interacts with and recruits the largest subunit of RNA polymerase II to CTCF target sites genome-wide Chernukhin, I., S. Shamsuddin, S.Y. Kang, R. Bergstrom, Y.-W. Kwon, W. Yu, J. Whitehead, R. Mukhopadhyay, F. Docquier, D. Farrar, I. Morrison, M. Vigneron, S.-Y. Wu, C.-M. Chiang, D. Loukinov, V. Lobanenkov, and E. Klenova Mol. Cell. Biol. 2007 27 1631-1648 Recruitment of TFIIH to the HIV LTR is a rate-limiting step in the emergency of HIV from latency Kim, Y.K., C.F. Bourgeois, R. Pearson, M. Tyagi, M.J. West, J. Wong, S.-Y. Wu, C.-M. Chiang, and J. Karn EMBO J. 2006 25 3596-3604 Dynamic localization of the human papillomavirus type 11 origin binding protein E2 through mitosis while in association with the spindle apparatus Dao, L.D., A. Duffy, B.A. Van Tine, S.-Y. Wu, C.-M. Chiang, T.R. Broker, and L.T. Chow J. Virol. 2006 80 4792-4800 SREBP-1c and Sp1 interact to regulate transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in the liver Chakravarty, K., S.-Y. Wu, C.-M. Chiang, D. Samols, and R.W. Hanson J. Biol. Chem. 2004 279 15385-15395