个人简介

World Bank-FOMEC Program, Argentina, Postdoctoral Fellowship - 2000; National Research Council, Argentina (CONICET), Postdoctoral Fellowship - 2000; Antorchas Foundation, Argentina, Postdoctoral Fellowship - 2000; Society of Analytical Chemists of Pittsburgh Award - 2004; American Society for Mass Spectrometry Research Award - 2005, "Professor Doctor Federico Luis Leloir" Award (Special Mention, Buenos Aires Univ.)-2006, Blanchard Assistant Professorship (Georgia Institute of Technology)-2006, NSF CAREER Award-2007; 3M Non-tenured Faculty Award-2008; CETL/BP Junior Faculty Teaching Excellence Award – 2009, Ron A. Hites Award for Outstanding Research Publication in the Journal of the American Society for Mass Spectrometry-2010, Sigma Xi (GT Chapter) Best Faculty Paper Award-2010, Hesburgh Award Teaching Fellow-2011, Vasser-Wooley Faculty Fellow-2012

研究领域

Analytical Chemistry/Characterization/Chemical and Biological Imaging/Chemical Biology/Chemical Evolution/Medicinal Chemistry/Planetary Science and Astrobiology

Our group is developing new types of ambient plasma, laser, and spray-based ion generation technologies that can be used for a number of applications, including those in the field and in space, or as new detectors for traditional chemical separation approaches, such as LC. We focus a large amount of our efforts on understanding the ionization mechanisms prevailing in ambient ion generation, and the fluid dynamic processes affecting ion transmission. We are also developing new instrumentation for applying ambient ionization approaches in microprobe MS imaging (MSI) modes. Ambient MSI applications in our lab include studies in traumatic brain injuries, imaging of surface chemical defenses on marine algae, and imaging of organics on minerals. All these projects are pursued in collaboration with researchers at GT (BME, Center for Chemical Evolution, Biology) or elsewhere.

近期论文

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“Electro-Thermal Vaporization Direct Analysis in Real Time-Mass Spectrometry (DART-ETV-MS) For Sensitive and High Throughput Water Contaminant Analysis During Space Missions”, Prabha Dwivedi, Thomas F. Limero, William T. Wallace, Daniel B. Gazda, Ariel V. Macatangay, Facundo M. Fernández. Anal. Chem., 2013, 85(20), 9898. [http://dx.doi.org/10.1021/ac402365k] “Mass Spectrometry-Recent Advances in Direct Open Air Surface Sampling/Ionization”, Maria Eugenia Monge, Glenn Harris, Prabha Dwivedi, Facundo M. Fernández, Chem. Rev. 2013, 113(4), 2269–2308. [http://dx.doi.org/10.1021/cr300309q] “Sensitivity “Hot Spots” in the Direct Analysis In Real Time Mass Spectrometry of Nerve Agent Simulants”, Glenn A. Harris, Caitlin E. Falcone and Facundo M. Fernández. J. Am. Soc. Mass Spectrom., 2012, 23, 153–161. [http://dx.doi.org/10.1007/s13361-011-0276-8] “Ambient Sampling/Ionization Mass Spectrometry: Applications and Current Trends", Glenn Harris, Asiri Galhena, Facundo M. Fernández, Anal. Chem., 2011, 83, 4508-4538. [http://dx.doi.org/10.1021/ac200918u] “Rapid Direct Analysis in Real Time (DART) Mass Spectrometric Detection of Juvenile Hormone III and its Terpene Precursors”, Arti T. Navare, Jaime G. Mayoral, Marcela Nouzova, Fernando G. Noriega, Facundo M. Fernández. Anal. Bioanal. Chem., 2010, 398, 3005-3013. [http://dx.doi.org/10.1007/s00216-010-4269-4] “Direct Analysis in Real Time (DART) Mass Spectrometric Analysis of Juvenile Hormone III its and Terpene Precursors”, Arti T. Navare, Jaime G. Mayoral, Marcela Nouzova, Fernando G. Noriega, Facundo M. Fernández*. Anal. Bioanal. Chem., 2010, 398, 3005-3013. [http://dx.doi.org/10.1007/s00216-010-4269-4 “In-line Pneumatically-Assisted Atmospheric Pressure Matrix-Assisted Laser Desorption/Ionization Ion Trap Mass Spectrometry”, Arti T Navare, Facundo M Fernández, J. Mass. Spectrom. 2010, 45(6), 635-642. [http://dx.doi.org/10.1002/jms.1749] “Comparison of the Internal Energy Deposition of Direct Analysis in Real Time and Electrospray Ionization Time-of-Flight Mass Spectrometry”, Glenn A. Harris, Dana M. Hostetler, Christina Y. Hampton, and Facundo M. Fernández, J. Am. Soc. Mass. Spectrom. 2010, 21, 855-863. [http://dx.doi.org/10.1016/j.jasms.2010.01.019] "Transmission-Mode Direct Analysis in Real Time and Desorption Electrospray Ionization Mass Spectrometry of Insecticide-Treated Bednets for Malaria Control”, José J. Pérez, Glenn A. Harris, Joseph E. Chipuk, Jennifer S. Brodbelt, Michael D. Green, Christina Y. Hampton, Facundo M. Fernández, Analyst, 2010, 135, 712-719. [http://dx.doi.org/10.1039/b924533b] “Microplasma Discharge Ionization Source for Ambient Mass Spectrometry” Joshua Symonds, Asiri Galhena, Facundo M. Fernández, Thomas Orlando, Anal. Chem., 2010, 82, 621-627. [http://dx.doi.org/10.1021/ac901964m] “Desorption Electrospray/Metastable-Induced Ionization (DEMI): A Flexible Multimode Ambient Ion Generation Technique”, Leonard Nyadong, Asiri S. Galhena, Facundo M. Fernández, Anal. Chem., 2009, 81, 7788-7794. [http://dx.doi.org/10.1021/ac9014098] “Beta Electron-Assisted Direct Chemical Ionization (BADCI) Probe for Ambient Mass Spectrometry”, Jennifer Steeb, Asiri S. Galhena, Leonard Nyadong, Jiří Janata and Facundo M. Fernández, Chem. Comm., 2009, 4699-4701. [http://dx.doi.org/10.1039/B909072J] “Simulations and Experimental Investigation of Atmospheric Transport in an Ambient Metastable-Induced Chemical Ionization Source”, Glenn A. Harris, Facundo M. Fernández*, Anal. Chem., 2009, 81, 322-329. [http://dx.doi.org/10.1021/ac802117u] “On-chip solid-phase extraction pre-concentration/focusing substrates coupled to atmospheric pressure matrix-assisted laser desorption/ionization ion trap mass spectrometry for high sensitivity biomolecule analysis”, Arti Navare, Marcela Nouzova, Fernando G. Noriega, Salvador Hernández-Martínez, Christoph Menzel, Facundo M. Fernández, Rap. Comm. Mass Spectrom., 2009, 23, 477-486. [http://dx.doi.org/10.1002/rcm.3890] “Desorption electrospray ionization reactions between host crown ethers and the influenza neuraminidase inhibitor oseltamivir for the rapid screening of Tamiflu”, Leonard Nyadong, Edward G. Hohenstein, Kristin Johnson, C. David Sherrill, Michael D. Green, and Facundo M. Fernández, The Analyst, 2008, 133, 1513-1522. [http://dx.doi.org/10.1039/b809471c] “Recent developments in ambient ionization techniques for high-throughput mass spectrometry”, Glenn A. Harris, Leonard Nyadong, Facundo M. Fernández, The Analyst, 2008, 133, 1297 – 1301. [http://dx.doi.org/10.1039/b806810k] “Comparison of the internal energy deposition of Venturi-assisted electrospray ionization and a Venturi-assisted array of micromachined ultrasonic electrosprays (AMUSE)”, Christina Y. Hampton, Catherine J. Silvestri, Thomas P. Forbes, Mark J. Varady, J. Mark Meacham, F. Levent Degertekin, Andrei G. Fedorov, Facundo M. Fernández, J. Am. Soc. Mass Spectrom., 2008, 19, 1320-1329. [http://dx.doi.org/10.1016/j.jasms.2008.06.012] “Direct quantitation of active ingredients in solid artesunate antimalarials by noncovalent complex forming reactive desorption electrospray ionization mass spectrometry”, Leonard Nyadong, Sameer Late, Michael D. Green, Ajay Banga, Facundo M. Fernández, J. Am. Soc. Mass Spectrom., 2008, 19, 380-388. [http://dx.doi.org/10.1016/j.jasms.2007.11.016] “Analytical performance of a Venturi-assisted array of micromachined ultrasonic electrosprays (AMUSE) coupled to ion trap mass spectrometry for the analysis of peptides and proteins”, Christina Y. Hampton, Thomas P. Forbes, Mark J. Varady, J. Mark Meacham, Andrei G. Fedorov, F. Levent Degertekin, Facundo M. Fernández, Anal. Chem., 2007, 79, 8154-8161. [http://dx.doi.org/10.1021/ac071297n] “Reactive desorption electrospray ionization linear ion trap mass spectrometry of genuine and latest-generation counterfeit antimalarials”, Leonard Nyadong, Michael D. Green, Victor de Jesus, Paul N. Newton, Facundo M. Fernández, Anal. Chem., 2007, 79, 2150-2157. [http://dx.doi/org/10.1021/ac062205h] “Characterization of solid counterfeit drug samples by desorption electrospray ionization and direct-analysis-in-real-time coupled to time-of-flight mass spectrometry”, Facundo M. Fernández, Robert B. Cody, Michael D. Green, Christina Y. Hampton, Rose McGready, Sivong Sengaloundeth, Nicholas J. White, Paul N. Newton, ChemMedChem, 2006, 1, 702-705. [http://dx.doi.org/10.1002/cmdc.200600041]