Thomas, Owen - University of Birmingham - School of Chemical Engineering

个人简介

Professor and Director of Biochemical Engineering, School of Chemical Engineering, UoB (since April 2004) Associate Professor of Biotechnological Separation Processes, Center for Process Biotechnology, Technical University of Denmark, Lyngby, Denmark (Nov 1996 – Mar 2004) Visiting Professor, Institüt für Technische Chemie, Forschungszentrum Karlsruhe GmbH, Leopoldshafen, Germany (June 2000 – Sept 2000) Founding member and Director of Research and Development, GeneCare ApS, DK-2800 Lyngby, Denmark (Nov 1997 – Apr 1998) Senior Research Fellow and Honorary Lecturer, The Advanced Centre for Biochemical Engineering, UCL, London, UK (Oct 1990 – Nov 1996) Wellcome/MRC Postdoctoral Research Associate, Department of Biochemistry, University of Cambridge, UK (Jul 1987 – Oct 1990)

近期论文

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Cao, P. Müller, T.K.H., Ketterer, B., Ewert, S., Theodosiou, E., Thomas, O.R.T. and Franzreb, M. (2015) Integrated system for temperature-controlled fast protein liquid chromatography. II. Optimized adsorbents and ‘single column continuous operation’ J. Chromatogr. A, online 3 June 2015, doi: 10.1016/jchroma.2015.05.039. Hsu, C.-C., Thomas, O.R.T. and Overton, T.W. (2015) Periplasmic expression in and release of Fab fragments from Escherichia coli using stress minimization. J. Chem. Technol. Biotechnol., online 21 March 2015, doi: 10.1002/jctb.4672. Jamshad, M., Grimard, V., Idini, I., Knowles, T.J., Dowle, M.R., Schofield, N. Sridhar, P., Lin, Y-P., Finka, R., Wheatley, M., Thomas, O.R.T., Palmer, R.E., Overduin, M., Govaerts, C., Ruysschaert, J-M., Edler, K.J., Dafforn, T.R. (2015) Structural analysis of a nanoparticle containing a lipid bilayer used for detergent-free extraction of membrane proteins. Nano Research 8(3):774-789; doi: 10.1007/s12274-014-0560-6. Fischer, I., G?rtner, Hsu, C-C., Müller, C., Overton, T.W., Thomas, O.R.T., Franzreb, M. (2013) ‘Continuous protein purification using functionalized magnetic nanoparticles and aqueous micellar two-phase systems’, J. Chromatogr. A, 1305: 7-16. DOI: 10.1016/j.chroma.2013.06.011 Olszewski, P., Willett, T.C., Theodosiou, E., Thomas, O.R.T., Walsh, J. L. (2013) ‘In situ modification of chromatography adsorbents using cold atmospheric pressure plasmas’, Appl. Phys. Lett., 102: 202104-1 – 20104-5. DOI: 10.1063/1.4807931. Müller, T.K.H., Cao, P., Ewert, S., Wohlgemuth, J., Liu, H., Willett, T.C., Theodosiou, E., Thomas, O.R.T., Franzreb, M. ‘Integrated system for temperature-controlled FPLC comprising improved copolymer modified beaded agarose adsorbents and a travelling cooling zone reactor (TCZR) arrangement’, J. Chromatogr. A, 1285: 97 – 109. DOI: 10.1016/j.chroma.2013.02.025. Brown, G.N., Müller, C., Theodosiou, E., Franzreb, M., Thomas, O.R.T. (2013) ‘Multi-cycle Recovery of Lactoferrin and Lactoperoxidase from Crude Whey using Fimbriated High-Capacity Magnetic Cation Exchangers and a Novel ‘Rotor-Stator’ High-Gradient Magnetic Separator’, Biotechnology and Bioengineering, 110(6): 1714 –1725. DOI: 10.1002/bit.24842. Jamshad, M., Lin, Y-P., Knowles, T.J. Parslow, R.A. Harris, C., Wheatley, M., Poyner, D.R., Bill, R.M., Thomas, O.R.T., Overduin, M. and Dafforn, T.R. (2011) ‘Surfactant-free purification of membrane proteins with intact native membrane environment’, Biochem. Soc. Trans., 39(3): 813-818. DOI: 10.1042/BST0390813. Arpanaei, A., Jensen, B.W., Theodosiou, E. Kingshott, P., Hobley, T.J., Thomas, O.R.T. (2010) ‘Surface modification of chromatography adsorbents by low temperature low pressure glow discharge plasma’, J. Chromatogr. A, 1217(44): 6905-6916. DOI: 10.1016/j.chroma.2010.08.069. Becker, J.S, Thomas, O.R.T. and Franzreb, M. (2009) ‘Protein separation with magnetic adsorbents in micellar aqueous two-phase systems’, Sep. Sci. Technol., 65(1): 46-53. Arpanaei, A., Heeb?ll-Nielsen, A., Hubbuch, J.J., Thomas, O.R.T. and Hobley, T.J. (2008) ‘Critical evaluation and comparison of fluid distribution systems for industrial scale expanded bed adsorption chromatography column’, J. Chromatogr. A, 1198-1199: 131-139. DOI: 10.1016/j.chroma.2008.05.44. Faber, C., Hobley, T.J.,Mollerup, J., Thomas, O.R.T. and Kaasgaard, S.G. (2008) ‘Factors affecting the solubility of Bacillus halmapalus a-amylase’, Chem. Eng. Processing, 47: 1007-117. DOI: 10.1016/j.cep.2007.02.015. Faber C., Hobley, T.J., Mollerup, J., Thomas, O.R.T. and Kaasgaard, S.G. (2007) ‘Study of the solubility of a modified Bacillus licheniformis a-amylase around the isoelectric point’, J. Chem. Eng. Data, 52: 707-713. Ebner, N., Gomes, C.S., Hobley, T.J., Thomas, O.R.T. and Franzreb, M. (2007) ‘Filter capacity predictions for the capture of superparamagnetic microparticles by high-gradient magnetic separation (HGMS)’ IEEE Trans. Magnetics, 43(5): 1941-1949. Bak, H., Kyhse-Andersen, J. and Thomas, O.R.T. (2007) ‘High-throughput immunoturbidimetric assays for in-process determination of polyclonal antibody concentration and functionality in crude samples’, J. Chromatogr. B, 848, 142-150. Bak, H, Thomas, O.R.T. and Abildskov, J. (2007)‘Lumped parameter model to predict initial breakthrough profiles from preparative chromatographic capture of polyclonal rabbit antibodies from clarified antiserum’, J. Chromatogr. B, 848, 131-141. Bak, H. and Thomas, O.R.T. (2007) ‘Evaluation of commercial chromatographic adsorbents for the direct capture of polyclonal rabbit antibodies from clarified antiserum’, J. Chromatogr. B, 848, 116-130. Franzreb, M., Siemann-Herzberg, M., Hobley, T.J., and Thomas, O.R.T. (2006) ‘Product recovery by high-gradient magnetic fishing (HGMF).’ In Process Scale Bioseparations for the Biopharmaceutical Industry, eds. A.A. Shukla, M.R. Etzel, S. Gadam, Taylor and Francis – CRC press (ISBN: 1574445170, publication date: 12/07/2006). Franzreb, M., Siemann-Herzberg, M., Hobley, T.J. and Thomas, O.R.T. (2006) ‘Protein purification using magnetic adsorbent particles’, Appl. Microb. Biotechnol., 70: 505-516. Guillaumie, F., Justesen, S.F.L., Mutenda, K.E., Roepstorff, P., Jensen, K.J. and Thomas, O.R.T. (2006) ‘Fractionation, solid-phase immobilization and chemical degradation of long pectin oligogalacturonides. Initial steps towards sequencing of oligosaccharides,’ Carbohydr. Res., 341(1): 118-129.