McConville, Chris - University of Birmingham

个人简介

Chris completed his PhD in 2008 in the School of Pharmacy at Queens University Belfast. The work involved the development and characterisation of a novel rod insert vaginal ring (RIVR) for the delivery of protein based HIV microbicides. His subsequent postdoctoral position (Oct 2008 to July 2010) was also conducted in the School of Pharmacy at QUB and involved the development and evaluation of novel vaginal ring formulations, polymer blends and solid dosage forms for the delivery of HIV microbicides. In July 2010 he was appointed as a senior lecturer in pharmaceutics at Curtin University, Perth, Western Australia, where he continued his research on the development of HIV microbicide products, while also focusing on the solubility enhancement of poorly soluble drugs, the development of biodegradable implantable drug delivery devices and the use of microparticles for controlled pulmonary drug delivery. In June 2012 he was appointed senior lecturer in pharmaceutics at the University of Wolverhampton. In 2015 he was appointed as a Senior Lecturer in Pharmaceutics, Formulation and Drug Delivery at the University of Birmingham. His research is focused on the development of implantable drug delivery devices for the localised treatment of brain tumours, the development of vaginal dosage forms for the treatment of gynaecological cancers and the development of micro and nanoparticles for the sustained delivery of chemotherapeutic drugs. He is also researching the development of novel vaginal rings and tablets for use as Multipurpose Prevention Technologies that deliver multiple drugs using a single formulation to prevent unintended pregnancy; HIV and HSV infections

近期论文

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Shergill M, Patel M, Khan S, Bashir A, McConville C (2015) Development and Characterisation of Sustained Release Solid Dispersion Oral Tablets Containing the Poorly Water soluble Drug Disulfiram. International Journal of Pharmaceutics. 497:3-11. Tawari, PE., Wang, Z., Najlah, M., Tsang, CW., Kannappan, V., Liu, P., McConville, C., He, B., Armesilla, AL., Wang, W (2015) The cytotoxic mechanisms of disulfiram and copper(II) in cancer cells. Toxicology Research. 4:1439-1442. McConville, C., Tawari, P., and Wang, W (2015) Hot Melt Extruded and Injection Moulded Disulfiram-Loaded PLGA Millirods for the Treatment of Glioblastoma Multiforme via Stereotactic Injection. International Journal of Pharmaceutics 494:73-82 Chatta, D., Cottrell, L., Burnett, B., Laverty, G., McConville C. (2015) The use of Water-Soluble Mucoadhesive gels for the Intravesical Delivery of Epirubicin to the Bladder for the Treatment of non-Muscle-Invasive Bladder Cancer. Journal of Pharmacy and Pharmacology 67:1355-62 McConville, C., (2015). The use of Localised Vaginal Drug Delivery as Part of a Neoadjuvant Chemotherapy Strategy in the Treatment of Cervical Cancer. Gynecology and Obstetrics Research. 2:26-28 McConville, C., and Major, I (2015). Hot Melt Extruded and Injection Moulded Dosage Forms: Recent Research and Patents. Recent Patents on Drug Delivery & Formulation. 9: 194-200. McConville, C (2015). The Therapeutic Potential of Vaginal Drug Delivery in the Treatment of Cervical Cancer. Therapeutic Delivery. 6:559-70. Zembko, I., Ahmed, I., Farooq, A., Dail, J., Tawari, P., Wang, W., and McConville, C (2015). Development of Disulfiram-loaded PLGA Wafers for the Localised Treatment of Brain Tumours: A Comparison of Manufacturing Techniques. Journal of Pharmaceutical Science. 104: 1076-1086. McConville, C., Smith, J.M., McCoy, C.F., Srinivasan, P., Mitchell, J., Holder, A., Otten, R.A., Butera, S., Doncel, G.F., Friend , D.R., Malcolm, R.K (2015). Lack of in vitro–in vivo correlation for a UC781-releasing vaginal ring in macaques. Drug Delivery and Translational Research. 5(1): 27-37. ISSN: 2190-3948 Baffoe, C.S., Nguyen, N., Boyd, P., Wang, W., Morris, M., and McConville, C (2015). Preformulation and Development of Disulfiram-Loaded Immediate and Extended Release Vaginal Tablets for the Localised Treatment of Cervical Cancer. Journal of Pharmacy and Pharmacology. 67(2): 189-198. McConville, C (2014). Localised Drug Delivery for the Treatment of Cancer. Cancer Studies: Open Access. 1(1): 1-7. McConville, C (2014). HIV Microbicides and Multiple Prevention Technology as Methods to Stop the Spread of HIV. Austin Journal of HIV/AIDS Research. 1(2): 2-3. McConville, C (2014). HIV Microbicides and Multipurpose Prevention Technology in Preventing the Spread of HIV/AIDS. Clinical Research in HIV/ AIDS. 1(2): 1012-1019. Ramadhani, N., Shabir, M., and McConville, C (2014). Preparation and characterisation of Kolliphor? P 188 and P 237 solid dispersion oral tablets containing the poorly water soluble drug disulfiram. International Journal of Pharmaceutics. 475(1–2): 514–522. Boyd, P., Major, I., Wang, W., and McConville, C (2014). Development of Disulfiram-Loaded Vaginal Rings for the Localised Treatment of Cervical Cancer. European Journal of Pharmaceutics and Biopharmaceutics. 88(3):945-53. ISSN: 0939-6411 McConville, C., Boyd, P., and Major, I (2014). Efficacy of tenofovir 1% vaginal gel in reducing the risk of HIV-1 and HSV-2 infection. Clinical Medicine Insights: Women’s Health, 7: 1-8. McConville, C., Friend, D., Clarke, M. R., and Malcolm, R.K (2013). Preformulation and development of a once-daily sustained-release tenofovir vaginal tablet containing a single excipient. Journal of Pharmaceutical Science, 102(6): 1859-1868. McConville, C., and Friend, D (2013). Development and characterisation of a self-microemulsifying drug delivery systems (SMEDDSs) for the vaginal administration of the antiretroviral UC-781. European Journal of Pharmaceutics and Biopharmaceutics, 83(3): 322-329. McConville, C., Major, I., Friend, D., Clarke, M. R., and Malcolm, R.K (2012). Development of a UC781 Releasing Poly Ethylene Vinyl Acetate Vaginal Ring. Drug Delivery and Translational Research, 2(6): 489-497. McConville, C., Woolfson, A. D., and Malcolm, R. K (2012). The effect of freeze-drying parameters on the cure characteristics of freeze-dried BSA-loaded silicone elastomer. Journal of Applied Polymer Science, 127(6): 4402-4408.