Wang, Linfa - National University of Singapore

个人简介

Education University of California, Davis Ph.D. Biochemistry (Molecular Biology), 1986 East China Normal University, Shanghai B.S. (Honors) Biology (Biochemistry), 1982 Professional Experience Professor, Programme in Emerging Infectious Diseases, Duke-NUS Medical School. - present Director and Professor, Programme in Emerging Infectious Diseases, Duke-NUS Medical School. 2012 -2020 OCE Science Leader, CSIRO Australian Animal Health 2008 Laboratory, Geelong, Vic. 2008 - 2015 Senior Principal Research Scientist and project leader, CSIRO Australian Animal Health Laboratory, Geelong, Vic. 2004 – 2008 Project Leader, Australian Biosecurity Cooperative Research Centre for Emerging Infectious Diseases (AB-CRC), Brisbane, Qld. 2003 – 2010 Principal Research Scientist and project leader, CSIRO Australian Animal Health Laboratory, Geelong, Vic. 1996 – 2004 Senior Research Scientist and project leader, CSIRO Australian Animal Health Laboratory, Geelong, Vic. 1992 – 1996 Research Scientist, CSIRO Australian Animal Health Laboratory, Geelong, Vic. 1990 – 1992 Senior Research Officer, the Centre for Molecular Biology and Medicine, Monash University, Clayton, Vic. 1990 – 1990 Senior Tutor, Department of Biochemistry, Monash University, Clayton, Vic. 1989 – 1990 Postdoctoral Research Fellow, Department of Biochemistry, University of California, Davis. 1986 – 1989 Postgraduate Student, Department of Biochemistry, University of California, Davis. 1982 – 1986

研究领域

His recent research contributions include developing antibody based serological tests to detect the SARS-CoV-2 virus, responsible for the COVID-19 outbreak, and the early and successful culture of the virus from an infected patents sample. His team is currently focusing on research into the origin of SARS-CoV-2 and developing assays which can better assess vaccine efficacy in the context of a potential immunity passport strategy and the challenges faced by the emergence of different virus variants.

近期论文

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Irving A, Ahn M, Goh G, Anderson AE, Wang L-F. (2020) Why bats? Lessons from host defenses of a unique viral reservoir. Nature (in press) Goh G, Ahn M, Zhu F, Lee LB, Luo D, Irving AT, Wang L-F. (2020) Complementary regulation of caspase-1 and IL-1β reveals additional mechanisms of dampened inflammation in bats. Proc Natl Acad Sci U S A. 26:202003352. doi: 10.1073/pnas.2003352117. Tan CW, Chia WN, Qin X, Liu P, Chen MI-C, Tiu C, Hu Z, Chen VC-W, Young BE, Sia WR, Tan Y-J, Foo R, Yi Y, Lye DC, Anderson DE, Wang, L.-F (2020) A SARS-CoV-2 surrogate virus neutralization test based on antibody-mediated blockage of ACE2-spike protein-protein interaction. Nat Biotech DOI: 10.1038/s41587-020-0631-z Wang L-F, Anderson DE, Mackenzie JS, Merson MH (2020) From Hendra to Wuhan: what has been learned in responding to emerging zoonotic viruses. Lancet 395(10224):e33-e34. doi: 10.1016/S0140-6736(20)30350-0. Ahn M, Anderson DE, Zhang Q, Tan CW, Lim BL, Luko K, Wen M, Chia WN, Mani S, Wang LC, Ng JHJ, Sobota RM, Dutertre C-A, Ginhoux F, Shi Z-L, Irving A and Wang L-F. (2019) Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host. Nat Microbiol. doi: 10.1038/s41564-019-0371-3. Zhou P, Fan H, Lan T, Yang XL, Shi WF, Zhang W, Zhu Y, Zhang YW, Xie QM, Mani S, Zheng XS, Li B, Li JM, Guo H, Pei GQ, An XP, Chen JW, Zhou L, Mai KJ, Wu ZX, Li D, Anderson DE, Zhang LB, Li SY, Mi ZQ, He TT, Cong F, Guo PJ, Huang R, Luo Y, Liu XL, Chen J, Huang Y, Sun Q, Zhang XL, Wang YY, Xing SZ, Chen YS, Sun Y, Li J, Daszak P, Wang L-F, Shi ZL, Tong YG, Ma JY (2018). Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin. Nature doi: 10.1038/s41586-018-0010-9. Zhang, G., Cowled, C., Shi, Z., Huang, Z., Bishop-Lilly, K.A., Fang, X., Wynne, J.W., Xiong, Z., Baker, M.L., Zhao, W., Tachedjian, M., Zhu, Y., Zhou, P., Jiang, X., Ng, J., Yang, L., Wu, L., Xiao, J., Feng, Y., Chen, Y., Sun, X., Zhang, Y., Marsh, G.A., Crameri, G., Broder, C.C., Frey, K.G., Wang, L.-F. and Wang, J. (2013) Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity. Science 339: 456-460. Chua, K.B., Crameri, C., Hyatt, A., Yu, M., Tompang, M.R., Rosli, J., McEachern, J., Crameri, S., Kumarasamy, V., Eaton, B.T. and Wang, L.-F. (2007) A previously unknown reovirus of bat origin is associated with an acute respiratory disease in humans. Proc. Natl. Acad. Sci. USA 104: 11424-11429. Eaton, B.T., Broder, C.C., Middleton, D. and Wang, L.-F. (2006). Hendra and Nipah viruses: different and dangerous. Nature Reviews Microbiol. 4: 23-35. Li, W., Shi, Z., Yu, M., Ren, W., Smith, C., Epstein, J.H., Wang, H., Crameri, G., Hu, Z., Zhang, H., Zhang, J., McEachern, J., Field, H., Daszak, P., Eaton, B.T., Zhang, S., and Wang, L.-F. (2005) Bats are natural reservoir of SARS-like coronaviruses. Science 310: 676-679.