Wang, Yiming - University of Pittsburgh

个人简介

Yiming was born in Shanghai, China, and grew up in Boulder, Colorado. He graduated with an AB/AM degree in chemistry & physics and mathematics from Harvard University in 2008 after conducting research in the group of Professor Andrew Myers. After obtaining his PhD under the supervision of Professor Dean Toste at the University of California, Berkeley in 2013, he conducted postdoctoral research in the laboratory of Professor Stephen Buchwald at the Massachusetts Institute of Technology as a National Institutes of Health Postdoctoral Fellow. He joined the Department of Chemistry at the University of Pittsburgh in the Fall of 2017.

研究领域

The Wang Group is engaged in the discovery and development of new catalytic reactions for efficient, sustainable organic synthesis. Research activities in the group focus on the development of novel catalysts, reagents, and conditions for the construction of challenging bonds and stereocenters found in products of interest to pharmaceutical and materials research. Iron catalysis: Our group is investigating metal-assisted deprotonation as an underexplored catalytic strategy for the C–H functionalization of alkynes, alkenes, and allenes: Vinyl cation chemistry: Our group is also investigating applications of vinyl cation chemistry, including various hydrofunctionalization reactions of alkynes:

近期论文

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Transition Metal Mimetic π-Activation by Cationic Bismuth(III) Catalysts for Allylic C–H Functionalization of Olefins Using C═O and C═N Electrophiles Wang, R.; Martínez, S.; Schwarzmann, J.; Zhao, C. Z.; Ramler, J.; Lichtenberg, C.*; Wang, Y.-M.* J. Am. Chem. Soc. 2024, 146, 22122. A C–H Functionalization Approach to Diverse Nitrogenous Scaffolds Through Conjugate Addition of Catalytic Allyliron Nucleophiles Scrivener, S. G.; Wang, Y.-M.* Chem. Sci. 2024, 15, 8850. Synthesis of 1,3-Enynes by Iron-Catalyzed Propargylic C–H Functionalization: An Alkyne Analogue for the Eschenmoser Methenylation Dey, S.; Charlack, A. D.; Durham, A. C.; Zhu, J.; Wang, Y.; Wang, Y.-M.* Org. Lett. 2024, 26, 3355. (An OL top 20 most read article in May 2024) Enantioselective and Regiodivergent Synthesis of Propargyl- and Allenylsilanes through Catalytic Propargylic C−H Deprotonation Zhu, J.; Xiang, H.; Chang, H.; Corcoran, J. C.; Ding, R.; Xia, Y.; Liu, P.*; Wang, Y.-M.* Angew. Chem. Int. Ed. 2024, 63, e202318040. Iron-Mediated C−H Functionalization of Unactivated Alkynes for the Synthesis of Derivatized Dihydropyrrolones: Regioselectivity Under Thermodynamic Control Durham, A. C.; Liu, C. R.; Wang, Y.-M.* Chem. Eur. J. 2023, 29, e202301195. Iron-Catalyzed Coupling of Alkenes and Enones: Sakurai–Michael-type Conjugate Addition of Catalytic Allyliron Intermediates Scrivener, S. G.; Wang, Y.; Wang, Y.-M.* Org. Lett. 2023, 25, 1420. (An OL top 20 most read article in March 2023) Designed Iron Catalysts for Allylic C−H Functionalization of Propylene and Simple Olefins Wang, R.(+); Wang, Y.(+); Ding, R.; Staub, P. B.; Zhao, C. Z.; Liu, P.*; Wang, Y.-M.* Angew. Chem. Int. Ed. 2023, 62, e202216309. Synthesis of 1,1-Disubstituted Allenylic Silyl Ethers through Iron-Catalyzed Regioselective C(sp2)–H Functionalization of Allenes Ding, R.; Wang, Y.; Wang, Y.-M.* Synthesis 2023, 55, 733. α-C–H functionalization of π-Bonds Using Iron Complexes Xia, Y.; Wang, Y.-M.* Handbook of CH-Functionalization 2023, Wiley (book chapter) Vinyl Cation-Mediated Intramolecular Hydroarylation of Alkynes Using Pyridinium Reagents Corcoran, J. C.(+); Guo, R.(+); Xia, Y.; Wang, Y.-M.* Chem. Commun. 2022, 58, 11523. [(+): Equally contributing authors] Enantioselective and Diastereodivergent Allylation of Propargylic C–H Bonds Zhu, J.; Wang, Y.; Charlack, A. D.; Wang, Y.-M.* J. Am. Chem. Soc. 2022, 144, 15480. Enantioselective and Diastereodivergent Allylation of Propargylic C–H Bonds Zhu, J.; Wang, Y.; Charlack, A. D.; Wang, Y.-M.* J. Am. Chem. Soc. 2022, 144, 15480. Contrasteric Coupling of Allenes and Tetrahydroisoquinolines by Iron-catalysed Allenic C(sp2)–H Functionalisation Xia, Y.; Wade, N. W.; Palermo, P. N.; Wang, Y.*, Wang, Y.-M.* Chem. Commun. 2021, 57, 13329. Iron-Catalyzed Contrasteric Functionalization of Allenic C(sp2)–H Bonds: Synthesis of α-Aminoalkyl 1,1-Disubstituted Allenes Wang, Y.; Scrivener, S. G.; Zuo, X.-D.; Wang, R.; Palermo, P. N.; Murphy, E.; Durham, A. C.; Wang, Y.-M.* J. Am. Chem. Soc. 2021, ASAP. Regiocontrolled Coupling of Alkynes and Dipolar Reagents: Iron-Mediated [3+2] Cycloadditions Revisited Zhu, J.(+); Durham, A. C.(+); Wang, Y.; Corcoran, J. C.; Zuo, X.-D.; Geib, S. J.; Wang, Y.-M.* Organometallics 2021, 40, 2295. [(+): Equally contributing authors] Iron-Catalyzed α-C–H functionalization of π-Bonds: Cross-Dehydrogenative Coupling and Mechanistic Insights Wang, Y.; Zhu, J.; Guo, R.; Lindberg, H.; Wang, Y.-M.* Chem. Sci. 2020, 11, 12316. Redox-Neutral Propargylic C-H Functionalization by Using Iron Catalysis (Synpacts account) Durham, A. C.; Wang, Y.; Wang, Y.-M.* Synlett 2020, 31, 1747. (A Synlett top 10 most read article in September 2020) Stereodivergent Alkyne Hydrofluorination Using Protic Tetrafluoroborates as Tunable Reagents Guo, R.; Qi, X.; Xiang, H.; Geaneotes, P.; Wang, R.; Liu, P.*; Wang, Y.-M.* Angew. Chem. Int. Ed. 2020, 59, 16651. α-C–H Functionalization of π-Bonds Using Iron Complexes: Catalytic Hydroxyalkylation of Alkynes and Alkenes Wang, Y.; Zhu, J.; Durham, A. C.; Lindberg, H.; Wang, Y.-M.* J. Am. Chem. Soc. 2019, 141, 19594. (A JACS top 20 most read article in December 2019) Remote Migratory Cross-Electrophile Coupling and Olefin Hydroarylation Reactions Enabled by in Situ Generation of NiH Chen, F.; Chen, K.; Zhang, Y.; He, Y.; Wang, Y.-M.*; Zhu, S.* J. Am. Chem. Soc. 2017, 139, 13929.