Zhang, Fuzhong - Washington University in St. Louis - Department of Energy, Environmental and Chemical Engineering

个人简介

PhD, University of Toronto, 2009 MS, McMaster University, 2005 BS, Peking University, 2003 Fuzhong Zhang became an assistant professor in the Department of Energy, Environmental & Chemical Engineering at Washington University in St. Louis in 2012. He received his bachelor degree at Peking University, master at McMaster University, PhD at University of Toronto, and postdoctoral training at UC Berkeley/Joint BioEnergy Institute. Dr. Zhang is a recipient of the DARPA Young Faculty Award (2013), ORAU Junior Faculty Enhancement Award (2013), NSF CAREER Award (2014), Young Investigator Program from AFOSR, ONR, and HFSP (2015), NASA Early Career Faculty Award (2015), Biotech & Bioeng Daniel Wang Award (2016), Dean’s Faculty Award for Innovation in Research (2016), the SIMB Young Investigator Award (2017) and NIH Maximizing Investigators' Research Award (2019).

研究领域

Fuzhong Zhang’s research focuses on developing synthetic biology tools and systems for the sustainable production of structurally-defined chemicals and high-performance materials. Current research projects include: (1) engineering microbial metabolic dynamics and heterogeneity; (2) engineering metabolic pathways to produce structure-defined biofuels and chemicals; (3) developing microbial factories to produce high-performance materials.

近期论文

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Bowen C.H., Sargent C.J., Wang A., Zhu Y., Li J., Chang X., Mu X., Galazka J.M., Jun Y., Keten S., Zhang F.* Microbial Production of Megadalton Titin Yields Fibers with Advantageous Mechanical Properties. Nature Communications, doi: 10.1038/s41467-021-25360-6 (2021) Li J., Zhu Y., Yu H., Dai B., Jun Y., Zhang F.* Microbially Synthesized Polymeric Amyloid Fiber Promotes β-Nanocrystal Formation and Displays Gigapascal Tensile Strength. ACS Nano, doi: 10.1021/acsnano.1c02944 (2021) Schmitz A., Zhang F.* Massively parallel gene expression variation measurement of a synonymous codon library. BMC Genomics. 22, 149, doi: 10.1186/s12864-021-07462-z, (2021). Lin PC., Zhang F., Pakrasi HB. Enhanced limonene production in a fast-growing cyanobacterium through combinatorial metabolic engineering. Metab Eng Commun. 12, e00164, doi: 10.1016/j.mec.2021.e00164, (2021). Hartline C., Schmitz A., Han Y., Zhang F.,* Dynamic control in metabolic engineering: theories, tools and applications. Metab Eng. 63, 126-140, doi: 10.1016/j.ymben.2020.08.015, (2020). Han Y., Zhang F.,* Control strategies to manage trade-offs during microbial production. Curr Opin Biotechnol. 66, 158-164, doi: 10.1016/j.copbio.2020.07.004, (2020). Kim E., Qin X., Qiao JB., Zeng Q., Fortner J.D., Zhang F.,* Graphene oxide/mussel foot protein composites for high-strength and ultra-tough thin films. Sci Rep. 10, 19082. doi: 10.1038/s41598-020-76004-6, (2020). Hartline C., Mannan A.A., Zhang F.*, Oyarzún DA.*, Metabolite sequestration enables rapid recovery from fatty acid depletion in Escherichia coli. mBio, 11(2). pii: e03112-19. doi: 10.1128/mBio.03112-19. (2020) Evans T.D., Zhang F.,* Bacterial Metabolic Heterogeneity: Origins and Applications in Engineering and Infectious Disease. Curr Opin Biotechnol. 64, 183-189, doi: 10.1016/j.copbio.2020.04.007, (2020). Han Y., Zhang F.,* Heterogeneity coordinates bacterial multitasking in single cells. PLoS Comput Biol. 16(1):e1007643. doi: 10.1371/journal.pcbi.1007643. (2020) Lin PC, Zhang F, Pakrasi HB. Enhanced production of sucrose in the fast-growing cyanobacterium Synechococcus elongatus UTEX 2973. Sci Rep. 10(1):390. doi: 10.1038/s41598-019-57319-5. (2020) Bowen C.H., Reed T.J., Sargent C.J., Mpamo B., Galazka J.M., Zhang F.*, Seeded Chain-Growth Polymerization of Proteins in Living Bacterial Cells. ACS Synthetic Biology, 8. 2651-2658. doi.org/10.1021/acssynbio.9b00362 (2019) Bai W., Sargent C.J., Choi J., Pappu R.V., Zhang F.*, Covalently-assembled, single-chain protein nanostructures with ultra-high stability. Nature Communications, 10, 3317. doi://doi.org/10.1038/s41467-019-11285-8 (2019) Roell G.W., Carr R.R., Campbell T., Shang Z., Henson W.R., Czajka J.J., Martín H.G., Zhang F., Foston M., Dantas G., Moon T.S., Tang Y. J., A concerted systems biology analysis of phenol metabolism in Rhodococcus opacus PD630. Metab Eng, 55, 120-130, doi: 10.1016/j.ymben.2019.06.013. (2019) Bai W., Geng W., Wang S., Zhang F., Biosynthesis, Regulation and Engineering of Microbially-produced Branched Biofuels. Biotechnol Biofuels, 12:84. doi:10.1186/s13068-019-1424-9. (2019). Dai B., Sargent C.J., Gui X., Liu C., Zhang F., Fibril self-assembly of amyloid–spider silk block polypeptides. Biomacromolecules, 20(5):2015-2023. doi: 10.1021/acs.biomac.9b00218. (2019) Kim E., Dai B., Qiao J.B., Li W., Fortner J.D., Zhang F., Microbially Synthesized Repeats of Mussel Foot Protein Display Enhanced Underwater Adhesion. ACS Appl. Mater. Interfaces, 10 (49), 43003–43012 (2018) DOI: 10.1021/acsami.8b14890. Bowen C.H.*, Dai B.*, Sargent C.J., Bai W, Ladiwala P, Feng H., Huang W, Kaplan D.L., Galazka J.M., Zhang F., Recombinant Spidroins Replicate Mechanical Properties of Natural Spider Silk. Biomacromolecules, 19 (9), 3853–3860 (2018) DOI: 10.1021/acs.biomac.8b00980. *These authors contributed equally. Xiao Y, Wang S, Rommelfanger S, Balassy A, Barba-Ostria C, Gu P, Galazka JM, Zhang F. Developing a Cas9-based tool to engineer native plasmids in Synechocystis sp. PCC 6803. Biotechnol Bioeng. Jun 13. (2018) doi: 10.1002/bit.26747. Guamán LP*, Barba-Ostria C*, Zhang F, Oliveira-Filho ER, Gomez JGC, Silva LF. Engineering xylose metabolism for production of polyhydroxybutyrate in the non-model bacterium Burkholderia sacchari. Microb Cell Fact. 17(1):74. (2018) doi: 10.1186/s12934-018-0924-9.*These authors contributed equally.