Woodman , Tim - University of Bath - Department of Pharmacy and Pharmacology

个人简介

BSc Hons (1st) Inorganic Chemistry, University of Warwick 1994 PhD Inorganic Chemistry, University of Warwick 1998 Royal Society Visiting Fellow, Auckland University, New Zealand 1998-1999 Post Doctoral Research Officer, University of Leeds, UK, 1999-2000 Post Doctoral Research Officer, University of East Anglia, UK, 2000-2005 NMR Spectroscopist, University of Bath, UK, 2005 -

研究领域

The role of alpha methyl acyl CoA racemase (AMACR/P504S) in prostate cancer. AMACR is an enzyme that is over-expressed in all cases of prostate cancer, and is currently of interest both as a better marker for the disease than the current prostate specific antigen (PSA) test and also as a potential target for inhibition by drug molecules. With Dr Matthew Lloyd, our research group of two PhD students is exploring the molecular biology of AMACR and attempting to identify high-throughput screening methods that will allow the isolation of potential inhibitors for this enzyme. Use of diffusion ordered NMR spectroscopy (DOSY) and PCA to characterise complex mixtures. DOSY can be applied to complex mixtures to enable the identification of individual compounds with the population. PCA is a technique where large amounts of data are reduced to a set of more simple components, providing much information on how similar (or different) further samples are from these components. Projects involving these techniques include the characterization of seized drug samples and the properties and origins of wines and whiskies.

近期论文

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Jevglevskis, M., Lee, G. L., Nathubhai, A., James, T., Threadgill, M., Woodman, T. and Lloyd, M., 2016. A convenient colorimetric assay for alpha-methylacyl-CoA racemase (AMACR; P504S) and testing for inhibitors. Jevglevskis, M., Lee, G. L., Nathubhai, A., James, T., Threadgill, M., Woodman, T. and Lloyd, M., 2016. A Convenient Colorimetric Assay for α-Methylacyl-CoA Racemase (AMACR; P504S) and Testing Of Inhibitors. In: Cancer Research @ Bath 13th symposium, 2016-04-27 - 2016-04-27, University of Bath. Jevglevskis, M., Lee, G. L., Sun, J., Zhou, S., Sun, X., Kociok-Kohn, G., James, T., Woodman, T. and Lloyd, M., 2016. A Study On The α-Methylacyl-CoA Racemase (AMACR) Elimination Reaction And Its Application To Inhibitor Testing. In: Cancer Research @ Bath 13th symposium, 2016-04-27 - 2016-04-27, University of Bath. Petrova, Y., Matan, H., Lee, G. L., Jevglevskis, M., Lloyd, M. and Woodman, T., 2016. High-throughput screening to identify novel inhibitors of human α-methylacyl-CoA racemase 1A (AMACR; P504S). In: Cancer Research @ Bath 13th symposium, 2016-04-27 - 2016-04-27, University of Bath. McKeown, P., Davidson, M.G., Lowe, J. P., Mahon, M. F., Thomas, L. H., Woodman, T. J. and Jones, M. D., 2016. Aminopiperidine based complexes for lactide polymerisation. Dalton Transactions, 45 (12), pp. 5374-5387. Parker, H. J., Chuck, C. J., Woodman, T. and Jones, M. D., 2016. Degradation of a β-O-4 model lignin species by vanadium Schiff-base catalysts:influence of catalyst structure and reaction conditions on activity and selectivity. Catalysis Today, 269, pp. 40-47. Jevglevskis, M., Lee, G. L., Sun, J., Zhou, S., Sun, X., Kociok-Kohn, G., James, T. D., Woodman, T. J. and Lloyd, M. D., 2016. A study on the AMACR catalysed elimination reaction and its application to inhibitor testing. Organic and Biomolecular Chemistry, 14 (2), pp. 612-622. Jevglevskis, M., Lee, G. L., Nathubhai, A., James, T., Threadgill, M., Woodman, T. and Lloyd, M., 2015. A Convenient Colorimetric Assay for α-Methylacyl-CoA Racemase (AMACR; P504S) and Testing Of Inhibitors. In: Cancer Research @ Bath symposium, 2015-11-11 - 2015-11-11, University of Bath, Claverton Down cmpus, builidng 5W. Jevglevskis, M., Lee, G. L., Sun, J., Zhou, S., Sun, X., Kociok-Kohn, G., James, T., Woodman, T. and Lloyd, M., 2015. A Study On The α-Methylacyl-CoA Racemase (AMACR) Elimination Reaction And Its Application To Inhibitor Testing. In: Cancer Research @ Bath symposium, 2015-11-11 - 2015-11-11, University of Bath, Claverton Down cmpus, builidng 5W. Petrova, Y., Matan, H., Lee, G. L., Jevglevskis, M., Woodman, T. and Lloyd, M., 2015. High-throughput screening to identify novel inhibitors of human α-methylacyl-CoA racemase 1A (AMACR; P504S). In: Cancer Research @ Bath symposium, 2015-11-11 - 2015-11-11, University of Bath, Claverton Down cmpus, builidng 5W. Lloyd, Matthew, 2015. methods (AMACR):None. C122Q 1/533- WO 2015 /114383 A1, 06 August 2015. Jones, M., Brady, L., Mckeown, P. M., Buchard, A., Schafer, P. M., Thomas, L. H., Mahon, M. F., Woodman, T. J. and Lowe, J. P., 2015. Metal influence on the iso- and hetero-selectivity of complexes of bipyrrolidine derived Salan ligands for the polymerisation of rac-lactide. Chemical Science, 6 (8), pp. 5034-5039. Lee, G. L., Jevglevskis, M., Threadgill, M., Woodman, T. and Lloyd, M., 2015. New routes to fight castrate-resistant prostate cancer: targeting α-methylacyl-CoA racemase (AMACR). In: 10th CR@B (Cancer Research at Bath) symposium, 2014-11-12 - 2014-11-12, University of Bath. Lee, G. L., Jevglevskis, M., Woodman, T. and Lloyd, M., 2015. New routes to fight castrate-resistant prostate cancer: targeting α-methylacyl-CoA racemase (AMACR). In: SET for Britain, 2015-03-09 - 2015-03-09, House of Commons. Lee, G. L., Jevglevskis, M., Threadgill, M., Woodman, T. and Lloyd, M., 2015. New routes to fight castrate-resistant prostate cancer: targeting α-methylacyl-CoA racemase (AMACR). In: European School of Medicinal Chemistry, 2015-06-28 - 2015-07-03. Cybulski, M. K., Riddlestone, I. M., Mahon, M. F., Woodman, T. J. and Whittlesey, M. K., 2015. Stoichiometric and catalytic C-F bond activation by the trans-dihydride complex [Ru(IEt2Me2)2(PPh3)2H2] (IEt2Me2 = 1,3-diethyl-4,5-dimethylimidazol-2-ylidene). Dalton Transactions, 44 (45), pp. 19597-19605. Jevglevskis, M., Lee, G. L., Threadgill, M. D., Woodman, T. J. and Lloyd, M. D., 2014. The perils of rational design – unexpected irreversible elimination of fluoride from 3-fluoro-2-methylacyl-CoA esters catalysed by α-methylacyl-CoA racemase (AMACR; P504S). Chemical Communications, 50 (91), pp. 14164-14166. Hathout, R. M. and Woodman, T. J., 2014. NMR diffusion-ordered spectroscopy can explain differences in skin penetration enhancement between microemulsion formulations. Nanomedicine: Nanotechnology, Biology, and Medicine, 10 (7), pp. 1389-1390. Forder, T. R., Mahon, M. F., Davidson, M. G., Woodman, T. and Jones, M. D., 2014. Synthesis and characterisation of unsymmetrical Zr(iv) amine tris(phenolate) complexes and their application in ROP of rac-LA. Dalton Transactions, 43 (31), pp. 12095-12099. Jevglevskis, M., Threadgill, M. D., Woodman, T. J. and Lloyd, M. D., 2014. A novel elimination reaction catalysed by human alpha-methylacyl-CoA racemase (AMACR; P504S) and potential applications for measuring enzyme activity. In: Early Career Researchers Day, Prostate Cancer UK, 2014, 2014-03-20.