李兴淑 - 福州大学

个人简介

2006.09-2010.06 福州大学化学化工学院，制药工程专业，学士 2010.09-2015.06 福州大学化学学院，生物化工专业，博士（导师：黄剑东研究员） 2015.10-2018.11 韩国梨花女子大学化学与纳米科学院，博士后（合作导师：Juyoung Yoon） 2018.12-2019.05 加拿大多伦多大学药学院，博士后（合作导师：Shana O. Kelley） 2019.09-2020.02 韩国梨花女子大学化学与纳米科学院，博士后（合作导师：Juyoung Yoon） 2020.05-至今福州大学化学学院，闽江学者教授

研究领域

功能染料，超分子光敏剂，纳米诊疗剂主要从事基于功能染料分子构建具有疾病治疗与成像检测功能的超分子光敏剂和纳米诊疗剂，研究内容涉及到应用化学、药物化学和生物医学工程等多个学科的交叉领域。

近期论文

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M. Yang, X. Li*, J. Yoon*. Activatable supramolecular photosensitizers: advanced design strategies. Mater. Chem. Front., 2020, DOI: 10.1039/d0qm00827c. X. Li, Y. H. Jeong, N. Kwon, J. G. Park, G. Tian, H. R. Kim, J. D. Huang*, D. S. Lee*, J. Yoon*. In vivo-assembled phthalocyanine/albumin supramolecular complexes combined with a hypoxia-activated prodrug for enhanced photodynamic immunotherapy of cancer. Biomaterials, 2021, 266, 120430. B. D. Zheng, Q. X. He, X. Li*, J. Yoon*, J. D. Huang*. Phthalocyanines as contrast agents for photothermal therapy. Coord. Chem. Rev., 2021, 426, 213548. X. Li, J. F. Lovell*, J. Yoon*, X. Chen*. Clinical development and potential of photothermal and photodynamic therapies for cancer. Nat. Rev. Clin. Oncol., 2020, 17, 657-674. E. Lee, X. Li*, J. Oh, N. Kwon, G. Kim, D. Kim*, J. Yoon*. A boronic acid-functionalized phthalocyanine with an aggregation-enhanced photodynamic effect for combating antibiotic-resistant bacteria. Chem. Sci., 2020, 11, 5735. X. Li, E. Y. Park, Y. Kang, N. Kwon, M. Yang, S. Lee, W. J. Kim*, C. Kim*, J. Yoon*. Supramolecular phthalocyanine assemblies for improved photoacoustic imaging and photothermal therapy. Angew. Chem. Int. Ed., 2020, 59, 8630-8634. Z. H. Yu, X. Li, F. Xu, X. L. Hu, J. Yan, N. Kwon, G. R. Chen, T. Tang, X. Dong, Y. Mai*, D. Chen*, J. Yoon*, X. P. He*, H. Tian. A supramolecular-based dual-wavelength phototherapeutic agent with broad spectrum antimicrobial activity against drug resistant bacteria. Angew. Chem. Int. Ed., 2020, 59, 3658-3664. X. Li, K. Jeong, Y. Lee, T. Guo, D. Lee, J. Park, N. Kwon, J. H. Na, S. K. Hong, S. S. Cha, J. D. Huang*, S. Choi*, S. Kim*, J. Yoon*. Water-soluble phthalocyanines selectively bind to albumin dimers: a green approach toward enhancing tumor-targeted photodynamic therapy. Theranostics, 2019, 9, 6412-6423. X. Li, H. Fan, T. Guo, H. Bai, N. Kwon, K. H. Kim, S. Yu, Y. Cho, H. Kim, K. T. Nam*, J. Yoon*, X. B. Zhang*, W. Tan. A sequential protein-responsive nanophotosensitizer complex for enhancing tumor-specific therapy. ACS Nano, 2019, 13, 6702-6710. X. Li, S. Yu, Y. Lee, T. Guo, N. Kwon, D. Lee, S. C. Yeom, Y. Cho, G. Kim, J. D. Huang*, S. Choi*, K. T. Nam*, J. Yoon*. In vivo albumin traps photosensitizer monomers from self-assembled phthalocyanine nanovesicles: A facile and switchable theranostic approach. J. Am. Chem. Soc., 2019, 141, 1366-1372. X. Li, H. Bai, Y. Yang, J. Yoon*, S. Wang*, X. Zhang*. Supramolecular antibacterial materials for combatting antibiotic resistance. Adv. Mater., 2019, 31, 1805092. X. Li, B. D. Zheng, X. H. Peng, S. Z. Li, J. W. Ying, Y. Zhao, J. D. Huang*, J. Yoon*. Phthalocyanines as medicinal photosensitizers: developments in the last five years. Coord. Chem. Rev., 2019, 379, 147-160. X. Li, C. y. Kim, J. M. Shin, D. Lee, G. Kim, H. M. Chung*, K. S. Hong*, J. Yoon*. Mesenchymal stem cell-driven activatable photosensitizers for precision photodynamic oncotherapy. Biomaterials, 2018, 187, 18-26. X. Li, D. Lee, J. D. Huang*, J. Yoon*. Phthalocyanine-assembled nanodots as photosensitizers for highly efficient type I photoreactions in photodynamic therapy. Angew. Chem. Int. Ed., 2018, 57, 9885-9890. X. Li*, N. Kwon, T. Guo, Z. Liu*, J. Yoon*. Innovative strategies for hypoxic-tumor photodynamic therapy. Angew. Chem. Int. Ed., 2018, 57, 11522-11531. X. Li*, S. Lee, J. Yoon*. Supramolecular photosensitizers rejuvenate photodynamic therapy. Chem. Soc. Rev., 2018, 47, 1174-1188. X. Li, X. H. Peng, B. D. Zheng, J. Tang, Y. Zhao, B. Y. Zheng, M. R. Ke, J. D. Huang*. New application of phthalocyanine molecules: from photodynamic therapy to photothermal therapy by means of structural regulation rather than formation of aggregates. Chem. Sci., 2018, 9, 2098-2104. X. Li, S. Yu, D. Lee, G. Kim, B. Lee, Y. Cho, B. Y. Zheng, M. R. Ke, J. D. Huang*, K. T. Nam*, X. Chen*, J. Yoon*. Facile supramolecular approach to nucleic-acid-driven activatable nanotheranostics that overcome drawbacks of photodynamic therapy. ACS Nano, 2018, 12, 681-688. X. Li, C. y. Kim, S. Lee, D. Lee, H. M. Chung, G. Kim, S. H. Heo, C. Kim*, K. S. Hong*, J. Yoon*. Nanostructured phthalocyanine assemblies with protein-driven switchable photoactivities for biophotonic imaging and therapy. J. Am. Chem. Soc., 2017, 139, 10880-10886. X. Li, J. Kim, J. Yoon*, X. Chen*. Cancer-associated, stimuli-driven, turn on theranostics for multimodality imaging and therapy. Adv. Mater., 2017, 29, 1606857.