Xian, Ming - Brown University - Department of Chemistry

个人简介

Dr. Ming Xian received his B.S. in chemistry from Nankai University, China. He then joined Professor Jin-Pei Cheng’s group at Nankai for his early graduate study. In 1999, he moved to the Wayne State University to continue his research under Professor Peng George Wang. After received his Ph.D. in organic chemistry in 2003, he did postdoctoral research with Professor Amos B. Smith, III as a DOD postdoctoral fellow at the University of Pennsylvania. In August 2006, he joined the faculty at the Washington State University in the Department of Chemistry. He and his lab moved to Brown University in July 2020. Career Experience 2022- J. H. Metcalf Professor of Chemistry, Brown University, Providence, RI 2020-2022 Professor of Chemistry, Brown University, Providence, RI; Adjunct Professor, Washington State University, Pullman, WA 2017–2020 Ralph G. Yount Distinguished Professor, Washington State University, Pullman, WA 2016-2020 Associate Chair for Graduate Studies, Chemistry, WSU, Pullman, WA 2015-2020 Professor of Chemistry, Washington State University, Pullman, WA 2011 – 2014 Associate Professor of Chemistry, Washington State University, Pullman, WA 2006 – 2011 Assistant Professor of Chemistry, Washington State University, Pullman, WA Professional Service and Awards Jesse Houghton Metcalf Endowed Professorship, Brown University, 2022- “Molecule” Lectureship, Center for Chemical Imaging in Biomedicine, University of Cincinnati, 2022 Editor, Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) Fellow of the American Association for the Advancement of Science (AAAS), 2021 Editorial Board member, Journal of Sulfur Chemistry, 2021– External Advisory Committee Member, the Nebraska Center for Integrated Biomolecular Communication (NCIBC) (2020-) Guest Editor, Antioxidants & Redox Signaling (2020) World Science Leaders’ Lectureship, Tsukuba University, Japan, (2016) Tohoku Medical Society Lectureship, Tohoku University, Japan (2013, 2016) Visiting Professor (Honorary), Shanxi University, 2012, 2016, 2017, 2018 Visiting Professor (Honorary), Guangzhou Medical University, 2018 Mid-Career Achievement Award in Scholarship/Research/Creative Activities, College of Arts and Sciences, Washington State University (2013) NIH/NSF Study Panels (SBCA, SBCB, EBIT-J, BCMB-D, F04-WL, MDCN-B, MSFA, NOMD, CSDM, etc) Chair-Elect, American Chemical Society Washington-Idaho Border Section (2013) Teva USA Scholar Award, American Chemical Society (2012) Chinese-American Chemistry & Chemical Biology Professors Association (CAPA) Distinguished Faculty Award (2012) Burroughs Wellcome Fund (BWF) Collaborative Research Travel Award, 2012 Chair, Pacific Northwest Undergraduate Research Symposium on Organic Chemistry, 2010; Co-Chair, 2009&2011. NSF CAREER Award (2009) Young Faculty Achievement Award, College of Arts and Sciences, Washington State University (2009) Thieme Chemistry Journals Award (Synthesis, Synlett, Synfacts) (2009) U. S. Army Prostate Cancer Research Program Postdoctoral Fellowship (2005)

研究领域

The core of Dr. Xian’s research interests comprises the desire to combine organic synthesis with bioorganic chemistry to examine, understand, and solve problems of biological and medicinal significance. Currently our group is working on the following projects: Bioorthogonal reactions of S-nitrosothiols and new methods for the study of protein S-nitrosylation Synthetic applications of S-nitrosothiols Controllable hydrogen sulfide, persulfide, polysulfide donors New methods for the detection of reactive sulfur species in biological systems New chemical tools for reactive sulfur species research The development of bio-based materials Synthetic methodology development

近期论文

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Ni, X.; Marutani, E.; Shieh, M.; Lam, Y.; Ichinose, F.; Xian, M. Selenium-based catalytic scavengers for concurrent scavenging of H2S and reactive oxygen species. Angew. Chem. Int. Ed. In press. Bai, J.; Jiao, F.; Salmeron, A. G.; Xu, S.; Xian, M.; Huang, L.; Chen, D. B. Mapping pregnancy-dependent sulfhydrome unfolds diverse functions of protein sulfhydration in human uterine artery. Endocrinology, 2023, 164, bqad107. Xu, S.; Shieh, M.; Paul, B. D.; Xian, M. Hydrogen sulfide: recent development of its dual donors and hybrid drugs. Br. J. Pharmacol. 2023, in press. Tharmalingam, N.; Xu, S.; Felix, L. O.; Roy, B.; Xian, M.; Mylonakis, E.; Fuchs, B. B. Gold complex compounds that inhibit drug-resistant Staphylococcus aureus by targeting thioredoxin reductase. Front. Antibiot. 2023, 2, 1179354. Lindahl, S.; Xian, M. Recent development of polysulfides: Chemistry and biological applications. Curr. Opin. Chem. Biol. 2023, 75, 102325. Roy, B.; Shieh, M.; Ramush, G.; Xian, M. Organelle-targeted fluorescent probes for sulfane sulfur species. Antioxidants 2023, 12, 590. Li, Z.; Xia, H.; Sharp, III, T. E.; LaPenna, K. B.; Katsouda, A.; Elrod, J. W.; Pfeilschifter, J.; Beck, K. -F.; Xu, S.; Xian, M.; Goodchild, T. T.; Papapetropoulos, A.; Lefer, D. J. Endothelium-derived hydrogen sulfide modulates endothelial-mesenchymal transition in heart failure. Circulation Research, 2023, 132, 154-166. Roy, B.; Shieh, M.; Xu, S.; Ni, X.; Xian, M. A single component photo-responsive template for the controlled release of NO and H2S2. J. Am. Chem. Soc., 2023, 145, 277-287. Day, J. J.; Zhang, T.; Hamsath, A.; Neill, D. L.; Xu, S.; Qian, W. -J.; Xian, M. A chemical approach for the specific generation of cysteine sulfinylation. Tetrahedron Lett. 2023, 114, 154284. (Special issue in honor of Prof. John Wood). Shieh, M.; Xu, S.; Lederberg, O. L.; Xian, M. Detection of sulfane sulfur species in biological systems. Redox Biol. 2022, 57, 102502. Cui, Q.; Pan, T. W.; Shieh, M.; Kelly, S. S.; Xu, S.; Qian, W. J.; Xian, M. Controllable cycloadditions between 2H-(thio)pyran-2-(thi)ones and strained alkynes: a click-and-release strategy for COS/H2S generation. Org. Lett., 2022, 24, 7334-7338. Hamsath, A.; Lederberg, O. L.; Cui, Q.; Shieh, M.; Lam, Y.; Brummett, B. J.; Xu, S.; Robinson, J. R.; Xian, M. Intramolecular tetrazine-acryloyl cycloaddition: chemistry and applications. Chem. Sci. 2022, 13, 10336-10341. Shieh, M.; Ni, X.; Xu, S.; Lindahl, S. P.; Yang, M.; Matsunaga, T.; Flaumenhaft, R.; Akaike, T.; Xian, M. Shining a light on SSP4: a comprehensive analysis and biological applications for the detection of sulfane sulfurs. Redox Biol. 2022, 56, 102433. Li, Z.; Xia, H.; Sharp III, T. E.; LaPenna, K. B.; Elrod, J. W.; Casin, K. M.; Liu, K.; Calvert, J. W.; Chau, V. Q.; Salloum, F. N.; Xu, S.; Xian, M.; Nagahara, N.; Goodchild, T. T.; Lefer, D. J. Mitochondrial H2S Regulates BCAA Catabolism in Heart Failure. Circulation Research 2022, 131, 222-235. Kelly, S. S.; Ni, X.; Yuen, V.; Radford, M. N.; Xian, M. C-Nitrosothioformamide: a donor template for dual release of HNO and H2S. ChemBioChem 2022, 23, e202200101. (front cover) Xu, S.; Knight, J. R.; Brummett, B. J.; Shieh, M.; Cui, Q.; Wang, Y.; Ramush, G.; Xian, M. Benzothiazole-derived sulfones and sulfoxides as reactive templates for biothiols and sulfane sulfurs. Org. Lett. 2022, 24, 2546-2550. Amer, M.; Ni, X.; Xian, M.; Chen, R. K. Photo-responsive hydrogel Mns with interlocking control for easy extraction in sustained ocular drug delivery. ASME J. Eng. Sci. Med. Diagn. Ther. 2022, 5, 011001. Wang, Y.; Ni, X.; Chadha, R.; McCartney, C.; Lam, Y.; Brummett, B.; Ramush, G.; Xian, M. Methods for suppressing hydrogen sulfide in biological systems. Antioxid. Redox Signal. 2022, 36, 294-308. Li, X.; Day, N. J.; Gaffrey, M. J.; Feng, S.; Lin, T. D.; Paurus, V. L.; Monroe, M.; Moore, R. J.; Yang, B.; Xian, M.; Qian, W. J. Mass spectrometry-based direct detection of multiple types of protein thiol modifications in pancreatic beta cells under endoplasmic reticulum stress. Redox Biol. 2021, 46, 102111. Ni, X.; Li, X.; Shen, T. L.; Qian, W. J.; Xian, M. A sweet H2S/H2O2 dual release system and specific protein S-persulfidation mediated by thioglucose/glucose oxidase. J. Am. Chem. Soc. 2021, 143, 13325-13332. Miyazaki, Y.; Marutani, E.; Ikeda, T.; Ni, X.; Hanaoka, K.; Xian, M.; Ichinose, F. A sulfonyl azide based sulfide scavenger rescues mice from lethal hydrogen sulfide intoxication. Toxicol. Sci. 2021, 183, 393-403. Ni, X.; Kelly, S. S.; Xu, S.; Xian, M. The path to controlled delivery of reactive sulfur species. Acc. Chem. Res. 2021, 54, 3968-3978. Marutani, E.; Morita, M.; Hirai, S.; Kai, S.; Grange, R. M. H.; Miyazaki, Y.; Nagashima, F.; Traeger, L.; Magliocca, A.; Ida, T.; Matsunaga, T.; Flicker, D. R.; Corman, B. H. P.; Mori, N.; Yamazaki, Y.; Batten, A.; Li, R.; Tanaka, T.; Ikeda, T.; Nakagawa, A.; Atochin, D.; Ihara, H.; Olenchock, B. A.; Shen, X.; Nishida, M.; Hanaoka, K.; Kevil, C. G.; Xian, M.; Bloch, D. B.; Akaike, T.; Hindle, A. G.; Motohashi, H.; Ichinose, F. Sulfide catabolism ameliorates hypoxic brain injury. Nat. Commun. 2021, 12, 3108. Kelly, S. S.; Shen, T. L.; Xian, M.; Oxygen-to-oxygen silyl migration of alpha-siloxy sulfoxides and oxidation-triggered allicin formation. Org. Lett. 2021, 23, 3741-3745. Wang, Y.; Lam, Y.; McCartney, C.; Brummett, B.; Ramush, G.; Xian, M. Fluorescent probes for H2S detection: cyclization-based approaches. A chapter for the book “Hydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies”, Wiley Series in Drug Discovery and Development, 2021, accepted. Wang, Y.; Cai, L.; Chen, W.; Wang, D.; Xu, S.; Wang, L.; Kononov, M. A.; Ji. S.; Xian, M. Development of xanthene-based fluorescent dyes: machine learning-assisted prediction vs TD-DFT prediction and experimental validation. Chemistry-Methods, 2021, 1, 389-396. Knight, J. R.; Wang, Y.; Xu, S.; Chen, W.; Berkman, C. E.; Xian, M. A modular template for the design of thiol-triggered sensors and prodrugs. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2021, 247, 119072. (invited paper for the special issue of fluorescent probes) Duan, J.; Zhang, T.; Gaffrey, M. J.; Weitz, K. K.; Moore, R. J.; Li, X.; Xian, M.; Thrall, B. D.; Qian, W. J. Stochiometric quantification of the thiol redox proteome of macrophages reveals subcellular compartmentalization and susceptibility to oxidative perturbations. Redox Biol. 2020, 36, 101649. Chen, W.; Xian, M. Washington Red (WR) dyes and their imaging applications. Meth. Enzymol. 2020, 640, 149-163. Wang, Y.; Xu, X.; Xian, M. Specific reactions of RSNO/HSNO/HNO and their applications in the design of fluorescent probes. Chem. Eur. J. 2020, 26, 11673-11683. Li, X.; Li, N.; Huang, L.; Xu, S.; Hamsath, A.; Dai, L.; Zhang, M.; Zhang, H.; Zheng, X.; Wong, J. J. L.; Xian, M.; Yang, C. T.; Liu, J. Is hydrogen sulfide a concern during treatment of lung adenocarcinoma with ammonium tetrathiomolybdate? Front. Oncol. 2020, 10, 234. Hamsath, A.; Xian, M. Chemistry and chemical biology of selenenyl sulfides (RSeSR) and thioseleninic acids (RSeSH). Antioxid. Redox Signal. 2020, 33, 1143-1157. Zhao, X.; Liu, L.; An, T.; Xian, M.; Luckanagul, J. A.; Su, Z.; Lin, Y.; Wang, Q. A hydrogen sulfide releasing alginate dressing for effective wound healing. Acta Biomaterialia, 2020, 104, 85-94. Hamsath, A.; Xian, M. Trityl Thionitrite. Encyclo. Reagents for Org. Syn. 2020. Xu, S.; Wang, Y.; Parent, Z. T.; Xian, M. Diacyl disulfides as the precursors for hydrogen persulfides (H2S2). Bioorg. Med. Chem. Lett. 2020, 30, 126903. Olson, K. R.; Briggs, A.; Devireddy, M.; Xian, M.; Gao, Y. Are the beneficial effects of ‘antioxidant’ lipoic acid mediated through metabolism of reactive sulfur species? Free Radical Biol. Med. 2020, 146, 139-149. Yang, C. T.; Devarie-Baez, N. O.; Hamsath, A.; Fu, X. D.; Xian, M. S-Persulfidation: chemistry, chemical biology, and significance in health and disease. Antioxid. Redox Signal. 2020, 33, 1092-1114.