Watts, Andrew - University of Bath - Department of Pharmacy and Pharmacology

个人简介

My research interests lie at the interface of chemistry and biology, utilising synthetic organic chemistry to investigate biological systems. I am involved in the design, synthesis and use of substrate derivatives as tools to study enzymes of biological and medical importance, with a particular emphasis on carbohydrate processing enzymes. These studies range from detailed investigations into the catalytic mechanisms of enzymes, to the use of this information in the design and synthesis of compounds as potential drug candidates. Some of the current research projects in my group include

近期论文

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Watts, A. and Kantner, T., 2016. Characterization of reactions between water soluble trialkylphosphines and thiol alkylating reagents: Implications for protein conjugation reactions. Bioconjugate Chemistry Young, B. L., Ali Khan, M., Chapman, T. J., Parry, R., Connolly, M. A. and Watts, A. G., 2015. Evaluation of the physiochemical and functional stability of diluted REMSIMA? upon extended storage—A study compliant with NHS (UK) guidance. International Journal of Pharmaceutics, 496 (2), IJP15271. Fischer, M., Hopkins, A. P., Severi, E., Hawkhead, J., Bawdon, D., Watts, A. G., Hubbard, R. E. and Thomas, G. H., 2015. Tripartite ATP-independent Periplasmic (TRAP) Transporters use an arginine-mediated selectivity filter for high affinity substrate binding. Journal of Biological Chemistry, 290 (45), pp. 27113-27123. Hader, S. and Watts, A., 2013. The synthesis of a series of deoxygenated 2,3-difluoro-N-acetylneuraminic acid derivatives as potential sialidase inhibitors. Carbohydrate Research, 374, pp. 23-28. Lasheen, D. S., Ismail, M. A. H., Abou El Ella, D. A., Ismail, N. S. M., Eid, S., Vleck, S., Glenn, J. S., Watts, A. G. and Abouzid, K. A. M., 2013. Analogs design, synthesis and biological evaluation of peptidomimetics with potential anti-HCV activity. Bioorganic and Medicinal Chemistry, 21 (10), pp. 2742-2755. Kim, J.-H., Resende, R., Wennekes, T., Chen, H.-M., Bance, N., Buchini, S., Watts, A. G., Pilling, P., Streltsov, V. A., Petric, M., Liggins, R., Barrett, S., Mckimm-Breschkin, J. L., Niikura, M. and Withers, S. G., 2013. Mechanism-based covalent neuraminidase inhibitors with broad spectrum influenza antiviral activity. Science, 340 (6128), pp. 71-75. Watts, Andrew, 2012. Materials and methods relating to glycosylation. A61K47/48- EP2442831 (A2), 25 April 2012. Watts, Andrew, 2012. Functionalising reagents and their uses. CN102317305 (A), 11 January 2012. Watts, Andrew, 2011. Thiol-Functionalising Reagents and Their Uses. C07K1/13- EP2373675 (A2), 12 October 2011. Telford, J. C., Yeung, J. H. F., Xu, G. G., Kiefel, M. J., Watts, A., Hader, S., Chan, J., Bennet, A. J., Moore, M. M. and Taylor, G. L., 2011. The Aspergillus fumigatus Sialidase Is a 3-Deoxy-D-glycero-D-galacto-2-nonulosonic Acid Hydrolase (KDNase): Structural and mechanistic insights. Journal of Biological Chemistry, 286 (12), pp. 10783-10792. Watts, Andrew, 2010. Materials and Methods Relating to Glycosylation. A61K47/48- CA2768155 (A1), 23 December 2010. Watts, Andrew, 2010. Compounds for Treating Viral Infections. C07H7/02- WO2010029302 (A2), 18 March 2010. Resende, R., Glover, C. and Watts, A. G., 2009. Palladium-catalysed allylic amination for the direct synthesis of epi-4-alkylamino-N-acetylneuraminic acid derivatives. Tetrahedron Letters, 50 (28), pp. 4009-4011. Mackenzie, Amanda, 2009. Detection and Functionalisation of S-Nitrosylated Polypeptides. G01N33/68- WO2009024791 (A1), 26 February 2009. Hewinson, J., Moore, S. F., Glover, C., Watts, A. and Mackenzie, A. B., 2008. A key role for redox signaling in rapid P2X7 receptor-induced IL-1 β processing in human monocytes. The Journal of Immunology, 180 (12), pp. 8410-8420. Newstead, S. L., Potter, J. A., Wilson, J. C., Xu, G., Chien, C. -H., Watts, A. G., Withers, S. G. and Taylor, G. L., 2008. The structure of Clostridium perfringens NanI sialidase and its catalytic intermediates. Journal of Biological Chemistry, 283 (14), pp. 9080-9088. Damager, I., Buchini, S., Amaya, M. F., Buschiazzo, A., Alzari, P., Frasch, A. C., Watts, A. G. and Withers, S. G., 2008. Kinetic and mechanistic analysis of Trypanosoma cruzi trans-sialidase reveals a classical ping-pong mechanism with acid/base catalysis. Biochemistry, 47 (11), pp. 3507-3512.