Thompson, Andrew - University of Bath - Department of Pharmacy and Pharmacology

研究领域

Studies on the DNA Duplex Adducts of Anti-cancer agents by High Field NMR

近期论文

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Nathubhai, A., Haikarainen, T., Hayward, P. C., Munoz-Descalzo, S., Thompson, A. S., Lloyd, M. D., Lehtio, L. and Threadgill, M., 2016. Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases. European Journal of Medicinal Chemistry, 118, pp. 316-327. Paine, H. A., Nathubhai, A., Woon, E. C. Y., Sunderland, P. T., Wood, P. J., Mahon, M. F., Lloyd, M. D., Thompson, A. S., Haikarainen, T., Narwal, M., Lehtio, L. and Threadgill, M. D., 2015. Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro. Bioorganic and Medicinal Chemistry, 23 (17), pp. 5891-5908. Twum, E. A., Nathubhai, A., Wood, P. J., Lloyd, M. D., Thompson, A. S. and Threadgill, M. D., 2015. Initial development of a cytotoxic amino-seco-CBI warhead for delivery by prodrug systems. Bioorganic and Medicinal Chemistry, 23 (13), pp. 3481-3489. Kumpan, K., Nathubhai, A., Zhang, C., Wood, P. J., Lloyd, M. D., Thompson, A. S., Haikarainen, T., Lehtio, L. and Threadgill, M. D., 2015. Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases. Bioorganic and Medicinal Chemistry, 23, pp. 3013-3032. Nathubhai, A., Wood, P. J., Lloyd, M. D., Thompson, A. S. and Threadgill, M. D., 2013. Design and discovery of 2?arylquinazolin-4-ones as potent and selective inhibitors of tankyrases. ACS Medicinal Chemistry Letters, 4 (12), pp. 1173-1177. Qu, X., Allan, A., Chui, G., Hutchings, T. J., Jiao, P., Johnson, L., Leung, W. Y., Li, P. K., Steel, G. R., Thompson, A. S., Threadgill, M. D., Woodman, T. J. and Lloyd, M. D., 2013. Hydrolysis of ibuprofenoyl-CoA and other 2-APA-CoA esters by human acyl-CoA thioesterases-1 and -2 and their possible role in the chiral inversion of profens. Biochemical Pharmacology, 86 (11), pp. 1621-1625. Woon, E. C. Y., Sunderland, P. T., Paine, H. A., Lloyd, M. D., Thompson, A. S. and Threadgill, M. D., 2013. One-pot tandem Hurtley–retro-Claisen–cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs. Bioorganic and Medicinal Chemistry, 21 (17), pp. 5218-5227. Nathubhai, A., Patterson, R., Woodman, T. J., Sharp, H. E. C., Chui, M. T. Y., Chung, H. H. K., Lau, S. W. S., Zheng, J., Lloyd, M. D., Thompson, A. S. and Threadgill, M. D., 2011. N3-Alkylation during formation of quinazolin-4-ones from condensation of anthranilamides and orthoamides. Organic and Biomolecular Chemistry, 9 (17), pp. 6089-6099. Woodman, T. J., Wood, P. J., Thompson, A. S., Hutchings, T. J., Steel, G. R., Jiao, P., Threadgill, M. D. and Lloyd, M. D., 2011. Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S)-a potential mechanism for the anti-cancer effects of ibuprofen. Chemical Communications, 47 (26), pp. 7332-7334. Hopton, S. R. and Thompson, A. S., 2011. Nuclear magnetic resonance solution structures of inter- and intrastrand adducts of DNA cross-linker SJG-136. Biochemistry, 50 (21), pp. 4720-4732. Hopton, S. R. and Thompson, A. S., 2011. Manipulative interplay of two adozelesin molecules with d(ATTAAT)2 achieving ligand-stacked Watson-Crick and Hoogsteen base-paired duplex adducts. Biochemistry, 50 (19), pp. 4143-4154. Holbourn, K. P., Lloyd, M. D., Thompson, A. S., Threadgill, M. D. and Acharya, K. R., 2011. Cloning, purification, crystallization and preliminary crystallographic analysis of the human histone deacetylase sirtuin 1. Acta Crystallographica Section F-Structural Biology and Crystallization Communications, 67 (4), pp. 461-463. Sunderland, P. T., Dhami, A., Mahon, M. F., Jones, L. A., Tully, S. R., Lloyd, M. D., Thompson, A. S., Javaid, H., Martin, N. M. B. and Threadgill, M. D., 2011. Synthesis of 4-alkyl-, 4-aryl- and 4-arylamino-5-aminoisoquinolin-1-ones and identification of a new PARP-2 selective inhibitor. Organic and Biomolecular Chemistry, 9 (3), pp. 881-891. Sunderland, P. T., Woon, E. C. Y., Dhami, A., Bergin, A. B., Mahon, M. F., Wood, P. J., Jones, L. A., Tully, S. R., Lloyd, M. D., Thompson, A. S., Javaid, H., Martin, N. M. B. and Threadgill, M. D., 2011. 5-benzamidoisoquinolin-1-ones and 5-(ω-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2). Journal of Medicinal Chemistry, 54 (7), pp. 2049-2059. Woodman, T.J., Wood, P. J., Thompson, A. S., Hutchings, T. J., Jiao, P., Steel, G. R., Threadgill, M. D. and Lloyd, M. D., 2011. Chiral inversion of NSAID-CoA esters by human ∝-methylacyl-CoA racemase. In: Cancer Research @ Bath Conference, 2011, 2011-05-01. Rahman, K. M., Thompson, A. S., James, C. H., Narayanaswamy, M. and Thurston, D. E., 2009. The pyrrolobenzodiazepine dimer SJG-136 forms sequence-dependent intrastrand DNA cross-links and monoalkylated adducts in addition to interstrand cross-links. Journal of the American Chemical Society, 131 (38), pp. 13756-13766.