Wei, Wei - Institute for Systems Biology -

个人简介

Dr. Wei Wei is an Assistant Professor at the Institute for Systems Biology. He also has the positions of Affiliated Assistant Professor at the UCLA Department of Molecular and Medical Pharmacology and member of the Jonsson Comprehensive Cancer Center. He received his B.S. in Fundamental Sciences (Mathematics and Physics) at Tsinghua University (Beijing) and M.S. in Materials Sciences and Engineering at UC San Diego. He obtained his Ph.D. at California Institute of Technology in 2014 with cross-disciplinary training that included both physical and biological sciences. Before joining ISB, Wei was an Assistant Professor at UCLA until mid-2018. Wei received the Chinese Government Award for Outstanding Student Abroad in 2013. In 2014, he was the sole recipient of the Milton and Francis Clauser Doctoral Prize – the highest honor for a Caltech Ph.D. He received the Andy Hill Cancer Research Endowment Distinguished Researchers award in 2019. Currently, he is the co-director of the NCI-funded ISB/UCLA Physical Sciences in Oncology Program (PS-OP), and a Project Lead in NCI-funded NSB Cancer Center. 2014 Ph.D. in Materials Sciences, California Institute of Technology 2008 M.S. in Materials Sciences and Engineering, UC San Diego 2005 B.S. in Fundamental Sciences (Mathematics and Physics), Tsinghua University

研究领域

Wei’s research interests reside in a highly cross-disciplinary field of BioMEMS, molecular and cellular analysis, and systems biomedicine. Wei’s group is developing and deploying a unique suite of single-cell tools and computational approaches to cultivate new understanding in cancer systems biology and address significant questions in translational cancer research. Single-cell analysis, BioMEMS, cancer molecular diagnosis, cancer epigenetic plasticity, multivariate data analysis

近期论文

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Cheng, Hanjun, Zhonghan Li, Zhili Guo, Shiqun Shao, Li Mo, Wei Wei, and Min Xue. 2021. “Single-Cell Profiling of D-2-Hydroxyglutarate Using Surface-Immobilized Resazurin Analogs.” Biosensors and Bioelectronics, 113368. https://doi.org/10.1016/j.bios.2021.113368. Yang, Liu, Xiaowei Yan, Jie Chen, Qiong Zhan, Yingqi Hua, Shili Xu, Ziming Li, et al. 2021. “Hexokinase 2 Discerns a Novel Circulating Tumor Cell Population Associated with Poor Prognosis in Lung Cancer Patients.” Proceedings of the National Academy of Sciences of the United States of America 118 (11). https://doi.org/10.1073/pnas.2012228118. Cheng, Hanjun, Rong Fan, and Wei Wei. 2020. “Cancer Systems Biology in the Era of Single-Cell Multi-Omics.” Proteomics 20 (13): e1900106. https://doi.org/10.1002/pmic.201900106. Yang, Liu, Xiaowei Yan, Jie Chen, Qiong Zhan, Yingqi Hua, Shili Xu, Yu Dong, et al. 2020. “Resolving an Underrepresented Circulating Tumor Cell Population in Lung Cancer Enabled by Hexokinase 2 Analysis.” BioRxiv, 2020.04.27.064345. https://doi.org/10.1101/2020.04.27.064345. Su, Yapeng, Marcus Bintz, Yezi Yang, Lidia Robert, Alphonsus H. C. Ng, Victoria Liu, Antoni Ribas, James R. Heath, and Wei Wei. 2019. “Phenotypic Heterogeneity and Evolution of Melanoma Cells Associated with Targeted Therapy Resistance.” PLoS Computational Biology 15 (6): e1007034. https://doi.org/10.1371/journal.pcbi.1007034. Wei, Wei, and Rong Fan. 2019. “Special Issue on Single-Cell Multi-Omics for Immuno-Oncology and Cancer Systems Biology.” Proteomics, e1900235. https://doi.org/10.1002/pmic.201900235. Shao, Shiqun, Zhonghan Li, Hanjun Cheng, Siwen Wang, Nicole G. Perkins, Priyanka Sarkar, Wei Wei, and Min Xue. 2018. “A Chemical Approach for Profiling Intracellular AKT Signaling Dynamics from Single Cells.” Journal of the American Chemical Society. https://doi.org/10.1021/jacs.8b08931. Lu, Yao, Liu Yang, Wei Wei, and Qihui Shi. 2017. “Microchip-Based Single-Cell Functional Proteomics for Biomedical Applications.” Lab on a Chip 17 (7): 1250–63. https://doi.org/10.1039/c7lc00037e. Su, Yapeng, Wei Wei, Lidia Robert, Min Xue, Jennifer Tsoi, Angel Garcia-Diaz, Blanca Homet Moreno, et al. 2017. “Single-Cell Analysis Resolves the Cell State Transition and Signaling Dynamics Associated with Melanoma Drug-Induced Resistance.” Proceedings of the National Academy of Sciences of the United States of America 114 (52): 13679–84. https://doi.org/10.1073/pnas.1712064115. Su, Yapeng, Qihui Shi, and Wei Wei. 2017. “Single Cell Proteomics in Biomedicine: High-Dimensional Data Acquisition, Visualization, and Analysis.” Proteomics 17 (3–4). https://doi.org/10.1002/pmic.201600267. Tang, Yin, Zhuo Wang, Ziming Li, Jungwoo Kim, Yuliang Deng, Yan Li, James R. Heath, Wei Wei, Shun Lu, and Qihui Shi. 2017. “High-Throughput Screening of Rare Metabolically Active Tumor Cells in Pleural Effusion and Peripheral Blood of Lung Cancer Patients.” Proceedings of the National Academy of Sciences of the United States of America 114 (10): 2544–49. https://doi.org/10.1073/pnas.1612229114. Wei, Wei, Young Shik Shin, Min Xue, Tomoo Matsutani, Kenta Masui, Huijun Yang, Shiro Ikegami, et al. 2016. “Single-Cell Phosphoproteomics Resolves Adaptive Signaling Dynamics and Informs Targeted Combination Therapy in Glioblastoma.” Cancer Cell 29 (4): 563–73. https://doi.org/10.1016/j.ccell.2016.03.012. Xue, Min, Wei Wei, Yapeng Su, Dazy Johnson, and James R. Heath. 2016. “Supramolecular Probes for Assessing Glutamine Uptake Enable Semi-Quantitative Metabolic Models in Single Cells.” Journal of the American Chemical Society 138 (9): 3085–93. https://doi.org/10.1021/jacs.5b12187. Yang, Liu, Zhihua Wang, Yuliang Deng, Yan Li, Wei Wei, and Qihui Shi. 2016. “Single-Cell, Multiplexed Protein Detection of Rare Tumor Cells Based on a Beads-on-Barcode Antibody Microarray.” Analytical Chemistry 88 (22): 11077–83. https://doi.org/10.1021/acs.analchem.6b03086. Xue, Min, Wei Wei, Yapeng Su, Jungwoo Kim, Young Shik Shin, Wilson X. Mai, David A. Nathanson, and James R. Heath. 2015. “Chemical Methods for the Simultaneous Quantitation of Metabolites and Proteins from Single Cells.” Journal of the American Chemical Society 137 (12): 4066–69. https://doi.org/10.1021/jacs.5b00944. Jing, Yi, Xinyu Bao, Wei Wei, Chun Li, Ke Sun, David P. R. Aplin, Yong Ding, Zhong-Lin Wang, Yoshio Bando, and Deli Wang. 2014. “Catalyst-Free Heteroepitaxial MOCVD Growth of InAs Nanowires on Si Substrates.” The Journal of Physical Chemistry C 118 (3): 1696–1705. https://doi.org/10.1021/jp406428z. Yu, Jing, Jing Zhou, Alex Sutherland, Wei Wei, Young Shik Shin, Min Xue, and James R. Heath. 2014. “Microfluidics-Based Single-Cell Functional Proteomics for Fundamental and Applied Biomedical Applications.” Annual Review of Analytical Chemistry (Palo Alto, Calif.) 7: 275–95. https://doi.org/10.1146/annurev-anchem-071213-020323. Yu, Jing, Jing Zhou, Alex Sutherland, Wei Wei, Young Shik Shin, Min Xue, and James R. Heath. 2014. “Microfluidics-Based Single-Cell Functional Proteomics for Fundamental and Applied Biomedical Applications.” Annual Review of Analytical Chemistry 7 (1): 275–95. https://doi.org/10.1146/annurev-anchem-071213-020323. Wei, Wei, Young Shik Shin, Chao Ma, Jun Wang, Meltem Elitas, Rong Fan, and James R. Heath. 2013. “Microchip Platforms for Multiplex Single-Cell Functional Proteomics with Applications to Immunology and Cancer Research.” Genome Medicine 5 (8): 75. https://doi.org/10.1186/gm479. Wei, Wei, Qihui Shi, Francoise Remacle, Lidong Qin, David B. Shackelford, Young Shik Shin, Paul S. Mischel, R. D. Levine, and James R. Heath. 2013. “Hypoxia Induces a Phase Transition within a Kinase Signaling Network in Cancer Cells.” Proceedings of the National Academy of Sciences of the United States of America 110 (15): E1352-1360. https://doi.org/10.1073/pnas.1303060110.