杨恭 - 复旦大学 - 肿瘤研究所

个人简介

2001年毕业于中国科学院微生物研究所，获得博士学位。2001年至2005年先后在美国休斯敦霍华德·休斯医学研究所、美国M.D. Anderson肿瘤中心从事博士后研究工作。2005年任美国德克萨斯大学M.D. Anderson癌症研究中心病理系讲师，并于2008年升职为美国德克萨斯大学M.D. Anderson癌症研究中心病理系助理教授。2010年回国工作，担任复旦大学附属肿瘤医院研究所研究员，博士生导师，实验研究中心/研究所副主任。2012年6-8月作为客座教授在日本金沢大学癌症研究所工作。2013年至今，任复旦大学附属肿瘤医院研究所研究员，博士生导师,妇科肿瘤/肿瘤化疗研究课题组长/PI；复旦大学附属上海市第五人民医院特聘教授，博士生导师,中心实验室常务副主任,组织样本库/慢性病平台负责人。杨恭教授目前在Nature Communications，Molecular Cancer、JNCI、PNAS、Clin Cancer Res、JBC、Cancer Res、Theranotics、Molecular Therapy、Oncogene、Cancer letter、European Journal of Cancer、International Journal of Cancer等国际知名杂志上发表SCI论文近70余篇。主持国家自然科学基金/重大研发计划5项，教育部博士点基金博导类1项；上海市浦江人才计划1项；上海市卫生局局级基金2项；参与科技部重大研发计划（子课题）精准医学项目 1项，重大慢性非传染性疾病项目（子课题）1项。

研究领域

肿瘤微环境IL-8和ECM1促进肿瘤转移复发、干细胞分化和化疗抵抗的机制细胞永生化与转化动物模型构建及分析细胞衰老与恶性转化 RAS/P53相关基因突变与细胞凋亡、衰老以及EMT、自噬的关系肿瘤靶向药物的筛选与开发 DNA损伤修复与肿瘤放化疗抵抗及其与肿瘤干细胞调控的机制

近期论文

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Huijing Yin# , Jingshu Wang#, Hui Li#, Yinjue Yu#, Xiaoling Wang, Lili Lu, Cuiting Lv, Bin Chang, Wei Jin, Wenwen Guo, Chunxia Ren*, Gong Yang*. Extracellular matrix protein-1 secretory isoform promotes ovarian cancer through increasing alternative mRNA splicing and stemness. Nature Communications. 2021 Jul 9; 12(1):4230. Jiao Meng#, Kaiyi Liu#, Yang Shao#, Xu Feng, Zhaodong Ji, Bin Chang, Yan Wang*, Ling Xu*, Gong Yang*. ID1 confers cancer cell chemoresistance through STAT3/ATF6-mediated induction of autophagy. Cell Death & Disease. 2020 Feb 20; 11(2):137. Yang Shao#, Xiaomin Liu#, Jiao Meng#, Xiaofei Zhang, Zhongliang Ma*, Gong Yang*. MicroRNA-1251-5p Promotes Carcinogenesis and Autophagy via Targeting the Tumor Suppressor TBCC in Ovarian Cancer Cells. Molecular Therapy. 2019 Sep 4; 27(9):1653-64. Xiaofei Zhang#, Zihao Qi#, Huijing Yin, Gong Yang*. Interaction between p53 and Ras signaling controls cisplatin resistance via HDAC4- and HIF-1α-mediated regulation of apoptosis and autophagy. Theranostics.2019 Jan 30; 9(4):1096-114. Yan Wang #, Ziliang Wang#, Zihao Qi, Sheng Yin, Na Zhang, Yang Liu, Mingming Liu, Jiao Meng, Rongyu Zang*, Zhen Zhang*, Gong Yang*. The negative interplay between Aurora A/B and BRCA1/2 controls cancer cell growth and tumorigenesis via distinct regulation of cell cycle progression, cytokinesis, and tetraploidy. Mol Cancer, 2014 Apr 28; 13:94. Gong Yang#, Xue Xiao, Daniel G. Rosen, Xi Cheng, Xiaohua Wu, Bin Chang, Guangzhi Liu, Fengxia Xue, Mercado-Uribe Imelda, Paul Chiao, Xiang Du, Jinsong Liu*. The Biphasic Role of NF-{kappa}B in Tumor Progression and Chemoresistance of Ovarian Cancer. Clin Cancer Res, 2011 Apr 15; 17(8):2181-94. Gong Yang#, Daniel G. Rosen, Guangzhi Liu, Fan Yang, Xiaoqing Guo, Xue Xiao, Fengxia Xue, Mercado-Uribe Imelda, Jiaoti Huang, Sue-Hwa Lin, Gordon B. Mills, Jinsong Liu*.CXCR2 promotes ovarian cancer growth through dysregulated cell cycle, diminished apoptosis, and enhanced angiogenesis. Clin Cancer Res, 2010 Aug 1; 16(15):3875-86. Gong Yang#, Bin Chang, Fan Yang, Xiaoqing Guo, Kathy Qi Cai, Xue (Sherry)Xiao, Huamin Wang, Subrata Sen, Mien-Chie Hung, Gordon B. Mills, Sandy Chang, Asha S. Multani, Mercado-Uribe Imelda, Jinsong Liu*. Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. Clin Cancer Res, 2010 Jun 15; 16(12):3171-81. Guangzhi Liu#, Gong Yang #, Bin Chang, Imelda Mercado-Uribe, Miao Huang, Jingfang Zheng, Robert C. Bast, Sue-Hwa Lin, Jinsong Liu*. Stanniocalcin 1 and ovarian tumorigenesis. J Natl Cancer Inst, 2010 Jun 2; 102(11):812-27. Gong Yang#, Daniel G Rosen, Zhihong Zhang, Robert C Bast Jr, Gordon B Mills, Justin A Colacino, Imelda Mercado-Uribe, Jinsong Liu*. The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis. PNAS. 2006 Oct 31; 103(44):16472-7.