周宇 - 中国科学院上海药物研究所 -

个人简介

教育经历 1999.09 — 2003.07 沈阳药科大学制药工程学士 2003.09 — 2008.07 沈阳药科大学药物化学博士工作经历 2008.07 — 2010.07 中科院上海药物所博士后 2010.09 — 2016.09 中科院上海药物所副研究员 2016.09 — 2019.10 中科院上海药物所研究员 2019.10 — 至今中科院上海药物所研究员、课题组长

研究领域

药物化学、创新药物研究、高效合成技术开发

近期论文

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Qiaolan Yang, Chenglin Wu, Jianhui Zhou, Guoxue He, Hong Liu* and Yu Zhou*. Highly selective C–H bond activation of N-arylbenzimidamide and divergent couplings with diazophosphonate compounds: a catalyst-controlled selective synthetic strategy for 3-phosphorylindoles and 4-phosphorylisoquinolines. Org. Chem. Front. 2019, 6, 393-398. Chenglin Wu, Jianhui Zhou, Guoxue He, Huihui Li, Qiaolan Yang, Run Wang, Yu Zhou* and Hong Liu*. Ruthenium(II)-Catalyzed Selective C-H Bond Activation of Imidamides and Coupling with Sulfoxonium Ylides: An Efficient Approach for the Synthesis of Highly Functional 3-Ketoindoles. Org. Chem. Front. 2019, 6, 1183-1188. Jianhui Zhou, Jian Li, Yazhou Li, Chenglin Wu, Guoxue He, Qiaolan Yang, Yu Zhou* and Hong Liu*. Direct Synthesis of 3-Acylindoles through Rhodium(III)-Catalyzed Annulation of N-Phenylamidines with α-Cl Ketones. Org. Lett. 2018, 20, 7645-7649. Feifei Fang, Chunmei Zhang, Chaofan Zhou, Yazhou Li, Yu Zhou* and Hong Liu*. Rh(III)-Catalyzed C-H Activation of Benzoylacetonitriles and Tandem Cyclization with Diazo Compounds to Substituted Benzo[ de]chromenes. Org. Lett. 2018, 20, 1720-1724. Chaofan Zhou, Feifei Fang, Yilang Cheng, Yazhou Li, Hong Liu* and Yu Zhou*. Rh(III)‐Catalyzed C‐H Activation of Benzoylacetonitriles and Cyclization with Sulfoxonium Ylides to Naphthols. Adv. Synth. Catal. 2018, 360 (13), 2546-2551. Yazhou Li, Jianhui Zhou, Feifei Fang, Bin Xu, Hong Liu* and Yu Zhou*. Rhodium(III)-Catalyzed C-H Activation of alpha-Iminonitriles or alpha-Imino Esters and Cyclization with Acrylates to 2 H-Isoindoles. J. Org. Chem. 2018, 83, 11736-11746. Xiaowei Wu, Bao Wang, Shengbin Zhou, Yu Zhou* and Hong Liu.* Ruthenium-Catalyzed Redox-Neutral [4+1] Annulation of Benzamides and Propargyl alcohols via C-H Bond Activation. ACS Catal. 2017, 7, 2494–2499. Wenjing Xia, Hong Yao, Dan Liu, Linxiang Zhao, Yu Zhou* and Hong Liu*. Enantioselective N-Heterocyclic Carbene-Catalyzed [3+3] Annulation of α,β-Unsaturated Esters with Methyl Ketoimine. Adv. Synth. Catal. 2016, 358, 1864-1869. Yu Zhou, Jiang Wang, Zhanni Gu, Shuni Wang,Wei Zhu, Jose Acena,Vadim Soloshonok, Kunisuke Izawa, Hong Liu*. Next Generation of Fluorine-containing Pharmaceuticals Compounds Currently in Phase II-III Clinical Trials of Major Pharmaceutical Companies; New Structural Trends and Therapeutic Areas. Chem. Rev. 2016, 116, 422–518. Yu Zhou, Jun Liu, Mingyue Zheng, Shuli Zheng, Chunyi Jiang, Xiaomei Zhou, Dong Zhang, Jihui Zhao, Deju Ye, Mingfang Zheng, Hualiang Jiang, Dongxiang Liu, Jian Cheng and Hong Liu. Structural optimization and biological evaluation of 1,5-disubstituted pyrazole-3-carboxamines as potent inhibitors of human 5-lipoxygenase. Acta Pharmaceutica Sinica B. 2016, 6, 32–45.