Song, Yuanquan - University of Pennsylvania Perelman School of Medicine

个人简介

Education B.S. (Biotechnology), Shanghai Jiao Tong University, Shanghai, China, 2002 Ph.D. (Neuroscience), Perelman School of Medicine at the University of Pennsylvania, 2009 Specialty Certification Postgraduate Training Postdoctoral Fellow, Physiology, University of California, SanFrancisco; Howard Hughes Medical Institute, 2009-2016 Trainee, Spinal Cord Injury Research Training Program (SCITP) - 2 week course, Ohio State University, Department of Neuroscience, Ohio State University, Columbus, OH, 2015-2015 Awards and Honors University's Third Class Scholarship, Shanghai Jiao Tong University, 2000 University's Second Class Scholarship, Shanghai Jiao Tong University, 2001 Fine Science Tools Travel Award, University of Pennsylvania, 2005 Neuroscience Imaging Competition, Mahoney Institute of Neurological Sciences Retreat, University of Pennsylvania, 2008 Roman Reed Spinal Cord Injury Research Fund of California, 2012-2012 NIH/NINDS PA-11-197 NIH Pathway to Independence award (K99-R00), 2014-2019 IDDRC New Program Development Award/IDDRC at CHOP and Penn, 2016-2018 Roberts Functional Genomics Rapid Grant/CHOP, 2017-2018 CHOP Pilot grant, 2017-2018 Roberts Collaborative Forefront Grant/CHOP, 2018-2019 Wings for Life - Spinal Cord Research Foundation, 2018-2020 Craig H. Neilsen Foundation, 2019-2021 Roberts Functional Genomics Rapid Grant/CHOP, 2019-2019 The Foerderer award/CHOP, 2020-2021

研究领域

The long-term goal of the Song lab is to elucidate the cellular and molecular basis governing the formation, maintenance and function of neural circuits under physiological and pathological conditions, using both Drosophila and mammalian models. With a background in neural development, neural circuits and behavior, fly and mouse genetics, injury and neurodegeneration models, our lab offers a unique skillset and perspective for addressing physiological questions in developmental/functional neurobiology and neurological diseases.

近期论文

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The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation Li F*, Lo TY*, Miles L*, Wang Q*, Noristani HN, Li D, Niu J, Trombley S, Goldshteyn J, Wang C, Wang S, Qiu J, Pogoda K, Mandal K, Brewster M, Rompolas P, He Y, Janmey PA, Thomas GM, Li S, Song Y. Nature Communications 2021 Jun 22;12(1):3845. Pathogenic variants in SMARCA5, a chromatin remodeler, cause a range of syndromic neurodevelopmental features Li D*#, Wang Q*, Gong NN, Kurolap A, Feldman HB, Boy N, Brugger M, Grand K, McWalter K, Sacoto MJG, Wakeling E, Hurst J, March ME, Bhoj EJ, Nowaczyk MJM, Gonzaga-Jauregui C, Mathew M, Dava-Wala S, Siemon A, Bartholomew D, Huang Y, Lee H, Martinez JA, Schwaibold EMC, Brunet T, Choukair D, Pais LS, White SM, Christodoulou J, Brown D, Lindstrom K, Grebe T, Tiosano D, Kayser MS, Tan TY, Deardorff MA, Song Y#, Hakonarson A. Science Advances 2021 May 12;7(20):eabf2066. (#Co-corresponding author). Glial metabolic reprograming promotes axon regeneration and functional recovery in the central nervous system Li F, Sami A, Noristani HN, Slattery K, Qiu J, Groves T, Wang S, Veerasammy K, Chen YX, Morales J, Hanes P, Sehgal A, He Y, Li S*, and Song Y*. Cell Metabolism 2020 Sep 9;S1550-4131(20)30475-7. Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila Wang Q, Fan H, Li F, Sharum SR, Krishnamurthy V, Song Y*, Zhang K*. eLife 2020 Oct 6;9:e57395. (*Co-corresponding author). Bi-allelic loss-of-function variants in NUP188 cause a recognizable syndrome characterized by neurologic, ocular and cardiac abnormalities Muir AM, Cohen JL, Sheppard SE, Guttipatti P, Lo TY, Weed N, Doherty D, Fagerberg C, Kjærsgaard L, Larsen MJ, Wemmenhove-Lohner K, Hirsh Y, Zeevi DA, Zackai EH, Bhoj E, Song Y*, Mefford HC* (2020). Am J Hum Genet May 7;106(5):623-631. (*Co-corresponding author). The microtubule regulator ringer functions downstream of the RNA repair/splicing pathway to promote axon regeneration Monahan Vargas, EJ*, Matamoros AJ*, Qiu J*, Jan CH, Qin Wang, Gorczyca D, Han TW, Weissman JS, Jan YN, Banerjee S and Song Y (2020). Genes Dev Feb 1;34(3-4):194-208. The mechanosensitive ion channel Piezo inhibits axon regeneration Song Y*, Li D, Farrelly O, Miles L, Li F, Kim SE, Lo TY, Wang F, Li T, Thompson-Peer KL, Gong J, Murthy SE, Coste B, Yakubovich N, Patapoutian A, Yang X, Rompolas P, Jan LY, Jan YN* (2019). Neuron April 17;102(2):373-389. (*Co-corresponding author). The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation Li F*, Lo TY*, Miles L*, Wang Q*, Noristani HN, Li D, Niu J, Trombley S, Goldshteyn J, Wang C, Wang S, Qiu J, Pogoda K, Mandal K, Brewster M, Rompolas P, He Y, Janmey PA, Thomas GM, Li S, Song Y. Nature Communications 2021 Jun 22;12(1):3845. Pathogenic variants in SMARCA5, a chromatin remodeler, cause a range of syndromic neurodevelopmental features Li D*#, Wang Q*, Gong NN, Kurolap A, Feldman HB, Boy N, Brugger M, Grand K, McWalter K, Sacoto MJG, Wakeling E, Hurst J, March ME, Bhoj EJ, Nowaczyk MJM, Gonzaga-Jauregui C, Mathew M, Dava-Wala S, Siemon A, Bartholomew D, Huang Y, Lee H, Martinez JA, Schwaibold EMC, Brunet T, Choukair D, Pais LS, White SM, Christodoulou J, Brown D, Lindstrom K, Grebe T, Tiosano D, Kayser MS, Tan TY, Deardorff MA, Song Y#, Hakonarson A. Science Advances 2021 May 12;7(20):eabf2066. (#Co-corresponding author). The chromatin remodeler ISWI acts during Drosophila development to regulate adult sleep Gong NN, Dilley LC, Williams CE, Moscato EH, Szuperak M, Wang Q, Jensen M, Girirajan S, Tan TY, Deardorff MA, Li D, Song Y, Kayser MS. Science Advances 2021 In press. Genome-wide surveillance of transcription errors in response to genotoxic stress Fritsch C, Gout JF, Haroon S, Towheed A, Chung C, LaGosh J, McGann E, Zhang X, Song Y, Simpson S, Danthi PS, Benayoun BA, Wallace D, Thomas K, Lynch M, Vermulst M. PNAS 2021 In press. Glial metabolic reprograming promotes axon regeneration and functional recovery in the central nervous system Li F, Sami A, Noristani HN, Slattery K, Qiu J, Groves T, Wang S, Veerasammy K, Chen YX, Morales J, Hanes P, Sehgal A, He Y, Li S*, and Song Y*. Cell Metabolism 2020 Sep 9;S1550-4131(20)30475-7. Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila Wang Q, Fan H, Li F, Sharum SR, Krishnamurthy V, Song Y*, Zhang K*. eLife 2020 Oct 6;9:e57395. (*Co-corresponding author). Patterned neuronal activities dictate cell type-specific axon regeneration Ruppell KT*, Wang F*, Li F*, Shang Y, Gong J, Guttipatti P, Song Y, Xiang Y. Submitted. Bi-allelic loss-of-function variants in NUP188 cause a recognizable syndrome characterized by neurologic, ocular and cardiac abnormalities Muir AM, Cohen JL, Sheppard SE, Guttipatti P, Lo TY, Weed N, Doherty D, Fagerberg C, Kjærsgaard L, Larsen MJ, Wemmenhove-Lohner K, Hirsh Y, Zeevi DA, Zackai EH, Bhoj E, Song Y*, Mefford HC* (2020). Am J Hum Genet May 7;106(5):623-631. (*Co-corresponding author). Chloride intracellular channel 1 cooperates with potassium channel to promote medulloblastoma growth Francisco MA, Wanggou S, Fan JJ, Dong W, Chen X, Momin A, Abeysundara N, Min HK, Chan J, McAdam R, Sia M, Pusong RJ, Liu S, Patel N, Ramaswamy V, Kijima N, Wang LY, Song Y, Kafri R, Taylor MD, Li X, Huang X (2020). J. Exp. Med. 217.5: e20190971. The microtubule regulator ringer functions downstream of the RNA repair/splicing pathway to promote axon regeneration Monahan Vargas, EJ*, Matamoros AJ*, Qiu J*, Jan CH, Qin Wang, Gorczyca D, Han TW, Weissman JS, Jan YN, Banerjee S and Song Y (2020). Genes Dev Feb 1;34(3-4):194-208. The mechanosensitive ion channel Piezo inhibits axon regeneration Song Y*, Li D, Farrelly O, Miles L, Li F, Kim SE, Lo TY, Wang F, Li T, Thompson-Peer KL, Gong J, Murthy SE, Coste B, Yakubovich N, Patapoutian A, Yang X, Rompolas P, Jan LY, Jan YN* (2019). Neuron April 17;102(2):373-389. (*Co-corresponding author). A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression Chen X, Wanggou S, Bodalia A, Zhu M, Dong W, Fan FJ, Yin WC, Min HK, Hu M, Draghici D, Dou W, Li F, Coutinho FJ, Whetstone H, Kushida M, Dirks P, Song Y, Hui CC, Sun Y, Wang LY, Li X, Huang X (2018). Neuron Nov 21;100(4):799-815.e7. Targeted Delivery and Tolerability of MRI-Guided CED Infusion into the Cerebellum of NonHuman Primates Salegio E, Campagna MV, Allen PC, Stockinger DE, Song Y, Hwa GGC (2018). Human Gene Therapy Methods Aug;29(4):169-176.