Nudler, Evgeny A. - New York University School of Medicine - Department of Biochemistry and Molecular Pharmacology

个人简介

Education 1989 B.A. Biology Division of Biology, Moscow State University, Moscow, USSR 1992 M.S. Genetics Department of Genetics, Moscow State University, Russia 1995 Ph.D. Biochemistry Institute of Molecular Genetics, Russian Academy of Sciences Postdoctoral Training 1995-1997 Molecular Biology Dr. A. Goldfarb Public Health Research Institute, New York Academic Appointments 1997-2003 Assistant Professor, New York University School of Medicine, New York, NY 2003-2005 Associate Professor (tenured), New York University School of Medicine 2005-2008 Professor, Dept. of Biochemistry, NYU School of Medicine 2008- Julie Wilson Anderson Professor, NYU School of Medicine 2013- Investigator, Howard Hughes Medical Institute

研究领域

Mechanisms of Cellular Stress Responses Our lab studies fundamental issues concerning cellular adaptation to genotoxic and proteotoxic stress. In particular, we attempt to understand how cells rapidly detect damage to their macromolecules (DNA and proteins) to promptly activate corrective processes. The failure to react appropriately has major pathological and evolutionary consequences, such as mutagenesis, cellular transformation, aging, and cell death. We use various model systems, including bacteria, nematodes, and mammalian cells to study these processes, and have developed powerful genomic, proteomic, and analytical tools that enhance our research capabilities. Bacteria Nematodes Mammalian cells

近期论文

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Shatalin K, Nuthanakanti A, Kaushik A, Shishov D, Peselis A, Shamovsky I, Pani B, Lechpammer M, Vasilyev N, Shatalina E, Rebatchouk D, Mironov A, Fedichev P, Serganov A, Nudler E Inhibitors of bacterial H2S biogenesis targeting antibiotic resistance and tolerance. Science. 11 Jun 2021. 372(6547):1169-1175 Rabow Z, Morningstar T, Showalter M, Heil H, Thongphanh K, Fan S, Chan J, Martinez-Cerdeno V, Berman R, Zagzag D, Nudler E, Fiehn O, Lechpammer M Exposure to DMSO during infancy alters neurochemistry, social interactions, and brain morphology in long-evans rats. Brain Behav. 01 May 2021. 11(5):e02146 Valencia-Sanchez MI, Abini-Agbomson S, Wang M, Lee R, Vasilyev N, Zhang J, De Ioannes P, La Scola B, Talbert P, Henikoff S, Nudler E, Erives A, Armache KJ The structure of a virus-encoded nucleosome. Nat Struct Mol Biol. 01 May 2021. 28(5):413-417 Wang B, Svetlov V, Wolf YI, Koonin EV, Nudler E, Artsimovitch I Allosteric activation of SARS-CoV-2 RdRp by remdesivir triphosphate and other phosphorylated nucleotides. bioRxiv. 28 Apr 2021. epub ahead of print Grau D, Zhang Y, Lee CH, Valencia-Sanchez M, Zhang J, Wang M, Holder M, Svetlov V, Tan D, Nudler E, Reinberg D, Walz T, Armache KJ Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction. Nat Commun. 29 Jan 2021. 12(1):714 Hao Z, Epshtein V, Kim KH, Proshkin S, Svetlov V, Kamarthapu V, Bharati B, Mironov A, Walz T, Nudler E Pre-termination Transcription Complex: Structure and Function. Mol Cell. 01 Dec 2020. epub ahead of print Alexander Mironov, Tatyana Seregina, Konstantin Shatalin, Maxim Nagornykh, Rustem Shakulov, Evgeny Nudler CydDC functions as a cytoplasmic cystine reductase to sensitize Escherichia coli to oxidative stress and aminoglycosides Proc Natl Acad Sci U S A. 08 Sep 2020. epub Wu X, Siggel M, Ovchinnikov S, Mi W, Svetlov V, Nudler E, Liao M, Hummer G, Rapoport TA Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex. Science. 24 Apr 2020. 368(6489):epub ahead of print Svetlov V, Nudler E Towards the unified principles of transcription termination. EMBO J. 03 Feb 2020. 39(3):e104112 Magan A, Amman F, El-Isa F, Hartl N, Shamovsky I, Nudler E, Schroeder R, Sedlyarova N iRAPs curb antisense transcription in E. coli. Nucleic Acids Res. 18 Nov 2019. 47(20):10894-10905 Chou HT, Apelt L, Farrell DP, White SR, Woodsmith J, Svetlov V, Goldstein JS, Nager AR, Li Z, Muller J, Dollfus H, Nudler E, Stelzl U, DiMaio F, Nachury MV, Walz T The Molecular Architecture of Native BBSome Obtained by an Integrated Structural Approach. Structure. 03 Sep 2019. 27(9):1384-1394.e4 Luhachack L, Rasouly A, Shamovsky I, Nudler E Transcription factor YcjW controls the emergency H2S production in E. coli. Nat Commun. 28 Jun 2019. 10(1):2868 Hou L, Wang Y, Liu Y, Zhang N, Shamovsky I, Nudler E, Tian B, Dynlacht BD Paf1C regulates RNA polymerase II progression by modulating elongation rate. Proc Natl Acad Sci U S A. 27 Jun 2019. epub ahead of print Rasouly A, Nudler E Reactive oxygen species as the long arm of bactericidal antibiotics. Proc Natl Acad Sci U S A. 14 May 2019. 116(20):9696-9698 Valencia-Sanchez MI, De Ioannes P, Wang M, Vasilyev N, Chen R, Nudler E, Armache JP, Armache KJ Structural Basis of Dot1L Stimulation by Histone H2B Lysine 120 Ubiquitination. Mol Cell. 08 Apr 2019. epub ahead of print Schneider JA, Craven TW, Kasper AC, Yun C, Haugbro M, Briggs EM, Svetlov V, Nudler E, Knaut H, Bonneau R, Garabedian MJ, Kirshenbaum K, Logan SK Design of Peptoid-peptide Macrocycles to Inhibit the beta-catenin TCF Interaction in Prostate Cancer. Nat Commun. 23 Oct 2018. 9(1):4396 Toliver-Kinsky T, Cui W, Toro G, Lee SJ, Shatalin K, Nudler E, Szabo C H2S: a Bacterial Defense Mechanism Against the Host Immune Response. Infect Immun. 15 Oct 2018. epub ahead of print Gusarov I, Nudler E Glycogen at the Crossroad of Stress Resistance, Energy Maintenance, and Pathophysiology of Aging. Bioessays. 01 Sep 2018. 40(9):e1800033 Abolhasani Khaje N, Mobley CK, Misra SK, Miller L, Li Z, Nudler E, Sharp JS Variation in FPOP Measurements Is Primarily Caused by Poor Peptide Signal Intensity. J Am Soc Mass Spectrom. 01 Sep 2018. 29(9):1901-1907 Ekimova IV, Plaksina DV, Pastukhov YF, Lapshina KV, Lazarev VF, Mikhaylova ER, Polonik SG, Pani B, Margulis BA, Guzhova IV, Nudler E New HSF1 inducer as a therapeutic agent in a rodent model of Parkinson's disease. Exp Neurol. 01 Aug 2018. 306:199-208