个人简介
2019.1-present Research assistant professor, Cancer Biology Shanghai Institute for Advanced Immunochemical studies (SIAIS), ShanghaiTech University.
2015.3-2018.12 Research assistant professor, Stem Cell Research Shanghai Institute for Advanced Immunochemical studies (SIAIS), ShanghaiTech University.
2011.4-2015.2 Postdoc, Cancer Biology Yale Comprehensive Cancer Center, School of Medicine, Yale University, New Haven CT USA
2004-2010 Ph.D. Genetics Department of Molecular Biochemistry, Biophysics and Molecular Biology, Iowa State University, IA USA 50010
研究领域
Study drug resistant mechanisms in non-small cell lung cancer; developing new strategies to overcome drug resistance using novel techniques including Proteolysis targeting chimera technology (PROTAC), antibody drug conjugates (ADC) and immunotherapy
近期论文
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Anna Truini, Jacqueline H Starrett, Tyler F Stewart, Kumar Dilip Ashtekar, Zenta Walther, Anna Wurtz, David Lu, Jin H Park, Michelle DeVeaux, Xiaoling Song, Scott Gettinger, Daniel Zelterman, Mark A. Lemmon, Sarah B. Goldberg and Katerina Politi. The EGFR Exon 19 Mutant L747-A750>P Exhibits Distinct Sensitivity to Tyrosine Kinase Inhibitors in Lung Adenocarcinoma. Clin Cancer Res. 2019 Jun 10. pii: clincanres.0780.2019. doi: 10.1158/1078-0432.CCR-19-0780. [Epub ahead of print] PMID: 31182434
David G. McFadden, Katerina Politi, Arjun Bhutkar, Frances K. Chen, Xiaoling Song, Mono Pirun, Philip M. Santiago, Caroline Kim-Kiselak, James T. Platt, Emily Lee, Emily Hodges, Adam P. Rosebrock, Roderick T. Bronson, Nicholas D. Socci, Gregory J. Hannon, Tyler Jacks, and Harold Varmus. Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma. Proc Natl Acad Sci USA. 2016 Oct 18;113(42):E6409-E6417. Epub 2016 Oct 4. PMID: 27702896
Xiaoling Song, Pang-Dian Fan, Amlak Bantikassegn, Udayan Guha, David Threadgill, Harold Varmus and Katerina Politi. ERBB3-Independent Activation of the PI3K Pathway in EGFR-Mutant Lung Adenocarcinomas. Cancer Research. 2015 Epub Jan 16. DOI: 10.1158/0008-5472.
Amlak Bantikassegn, Xiaoling Song, Katerina Politi. Isolation of Epithelial, Endothelial, and Immune Cells From Lungs of Transgenic Mice with Oncogene-Induced Lung Adenocarcinomas. American Journal of Respiratory Cell and Molecular Biology 2014 Oct 27.
Valentina Pirazzoli*, Caroline Nebhan*, Xiaoling Song, Zenta Walther, Guoping Cai, Anna Wurtz, Zhongming Zhao, Elisa de Stanchina, Leora Horn, David Carbone, Vincent Miller, Scott Gettinger, William Pao and Katerina Politi. Acquired resistance of EGFR mutant lung adenocarcinomas to afatinib plus cetuximab is associated with activation of the mTORC1. Cell Reports. 2014 May 22; 7(4): 999-1008.
Xiaoling Song, Pang-Dian Fan, Udayan Guha, David Threadgill, Harold Varmus, Katerina Politi. Activation of Putative Compensatory Pathways upon Deletion of Erbb3 in Mutant EGFR-driven Lung Cancer. Clin Cancer Res. February 1, 2012 18:B35; doi:10.1158/1078-0432.12
Ken Takezawa, Valentina Pirazzoli*, Maria E. Arcila*, Caroline A. Nebhan#, Xiaoling Song, Elisa de Stanchina, Kadoaki Ohashi, Yelena Y. Janjigian, Paula J. Spitzler, Mary Ann Melnick, Greg J. Riely, Mark G. Kris, Vincent A. Miller, Marc Ladanyi, Katerina Politi, William Pao. HER2 amplification: a potential mechanism of acquired resistance to EGFR inhibition in EGFR mutant lung cancers that lack the second-site EGFR T790M mutation. Cancer Discovery. 2012 Oct; 2(10): 922-933. * or # : authors contributed equally. PMID: 2295664
Xiaoling Song, Frederic W. Thalacker and Marit Nilsen-Hamilton. Synergistic and multidimensional regulation of plasminogen activator inhibitor type 1 expression by transforming growth factor type β and epidermal growth factor. The Journal of Biological Chemistry. 2012 Apr 6; 287(15):12520-8. Epub 2012 Feb 10. PMID: 22334677
Xiaoling SongMarit NilsenHamilton. EGF cooperates with TGFβ to regulate PAI-1 expression by a synergistic increase in transcription and stabilization of mRNA. FASEB J. 2010 24:lb71.
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