Paine , Helen - University of Bath - Department of Pharmacy and Pharmacology

个人简介

I qualified as a Pharmacist in 2009 following a split pre-registration position with AstraZeneca and the University Hospitals of Leicester NHS trust. Post-qualification, the majority of my Pharmacy experience has been in the community. I have always been interested in the design of new medicines and as such, in 2013, I completed a PhD in Medicinal Chemistry where I developed and tested new potential anti-cancer medicines which work through inhibition of the tankyrases; enzymes involved in the regulation of telomere length. Throughout my PhD I was involved in teaching undergraduates here at Bath and having thoroughly enjoyed this experience, went on to complete a formal teaching qualification (PGCE) in 2014. I am particularly interested in how Pharmacy education can be delivered to undergraduates using creative and innovative techniques and approaches.

近期论文

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Paine, H. A., Nathubhai, A., Woon, E. C. Y., Sunderland, P. T., Wood, P. J., Mahon, M. F., Lloyd, M. D., Thompson, A. S., Haikarainen, T., Narwal, M., Lehtio, L. and Threadgill, M. D., 2015. Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro. Bioorganic and Medicinal Chemistry, 23 (17), pp. 5891-5908. Paine, H. A., 2014. Inhibitors of the tankyrases, triple-function targets in the cancer cell. Thesis (Doctor of Philosophy (PhD)). University of Bath. Woon, E. C. Y., Sunderland, P. T., Paine, H. A., Lloyd, M. D., Thompson, A. S. and Threadgill, M. D., 2013. One-pot tandem Hurtley–retro-Claisen–cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs. Bioorganic and Medicinal Chemistry, 21 (17), pp. 5218-5227.