Lloyd , Matthew - University of Bath - Department of Pharmacy and Pharmacology

个人简介

2002 Lecturer in Molecular Enzymology (University of Bath) 1995-2001 Senior Post-Doctoral Research Associate (University of Oxford) 1993-1994 Post-Doctoral Research Associate (Brown University) 1989-1992 D.Phil. 'Biosynthesis of Clavulanic acid' (University of Oxford) 1986-1989 Bsc (hons) Biological Chemistry (University of Leicester)

研究领域

Research in my group is aimed at understanding the in vivo role of proteins in metabolism in normal cells and diseases such as cancer. The work utilizes a wide range of different techniques, including molecular biology, expression and purification of recombinant proteins, activity assays, chemical rescue, steady-state kinetic analysis, and isolation of products and spectroscopic characterization

近期论文

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T. J. Woodman, P. J. Wood, A. S. Thompson, T. Hutchings, P. Jiao, G. R. Steel, M. D. Threadgill, M. D. Lloyd, "Chiral inversion of NSAID-CoA esters by human alpha-methylacyl-CoA racemase 1A", Chem. Commun., 2011, DOI:10.1039/C1CC10763A; P. T. Sunderland, E. C. Y. Woon, A. Dhami, A. B. Bergin, M. F. Mahon, P. J. Wood, L. A. Jones, S. R. Tully, M. D. Lloyd, A. S. Thompson, H. Javaid, N. M. B. Martin, M. D. Threadgill, 5-Benzamidoisoquinolin-1-ones and 5-(omega-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose)polymerase-2 (PARP-2), 2011, J. Med. Chem. 54, 2049-2059; S. Pilgrim, G. Kociok-Kohn, M. D. Lloyd, S. E. Lewis, "InosAminoAcids": Novel inositol-amino acid hybrid structures accessed by microbial arene oxidation", 2011, Chem. Commun. 47, 4799-4801; K. P. Holbourn, M. D. Lloyd, A.S. Thompson, M. D. Threadgill, K. R. Acharya, 'Cloning, purification, crystallisation and preliminary crystallographic analysis of the human histone deacetylase sirtuin 1, 2011, Acta Crys., F67, 461-463; P. T. Sunderland, A. Dhami, M. F. Mahon, L. A. Jones, S. R. Tully, M. D. Lloyd, A. S. Thompson, H. Javaid, N. B. Martin, M. D. Threadgill, 'Synthesis of 4-alkyl-, 4-aryl-, and arylamino-5-substituted isoquinolin-1-ones and identification of a new PARP-2 selective inhibitor", 2011, Org. Biomol. Chem. 9, 881-891. F. A. Sattar, D. J. Darley, F. Politano, T. J. Woodman, M. D. Threadgill and M. D. Lloyd, "Unexpected stereoselective exchange of straight-chain fatty acyl-CoA alpha-protons by human alpha-methylacyl-CoA racemase 1A (P504S)", 2010, Chem. Commun., 46, 3348-3350 G. Cozier, M. Leese, M. D. Lloyd, M. Baker, N. Thiayagarajan, K. R. Acharya and B. V. L. Potter, "Structures of human carbonic anhydrase II/inhibitor complexes reveal a second binding site for steroidal and non-steroidal inhibitors" 2010, Biochemistry, 49, 3464-3476 A. Dhami, M. F. Mahon, M. D. Lloyd and M. D. Threadgill, "4-Substituted 5-nitroisoquinolin-1-ones from intramolecular Pd-catalysed reaction of N-(2-alkenyl)-2-halo-3-nitrobenzamides", Tetrahedron, 2009, 65, 4751-4765. A.-M. Lord, M. Mahon, M. D. Lloyd and M. D. Threadgill, “Design, synthesis and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose) polymerase-1 (PARP-1) inhibitor”, J. Med. Chem., 2009, 52, 868-877. D. J. Darley, D. S. Butler, S. J. Prideaux, T. W. Thornton, A. D. Wilson, T. J. Woodman, M. D. Threadgill and M. D. Lloyd “Synthesis and use of isotope-labelled substrates for a mechanistic study on human α-methylacyl-CoA racemase 1A (AMACR; P504S)”, Org. Biomol. Chem., 2009, 7, 543-552. A. L. Ball, K. A. Chambers, M. Hewinson, S. Navaratnarajah, L. Samrin, N. Thomas, A. E. H. Tyler, A. J. Wall, M.D. Lloyd, “A microtitre plate assay for measuring glycosidase activity”, J. Enzy. Inhibit. Med. Chem., 2008, 23, 131-135. M. D. Lloyd, D. J. Darley, A. S. Wierzbicki, M. D. Threadgill “α-Methylacyl-CoA racemase: An ‘obscure’ metabolic enzyme takes centre stage”, FEBS J. 2008, 275, 1089-1102. M. 6.J. S. W. Kwong, M. F. Mahon, M. D. Lloyd, M. D. Threadgill, “Synthesis of diastereoisomeric homochiral O-protected 4-(arylsulfonimidoyl)butane-1,2,3-triols and conformational and configurational studies”. Tetrahedron, 2007, 12601-12607. M. D. Lloyd, K. D. E. Boardman, A. Smith, D. M. van den Brink, R. J. A. Wanders, and M. D. Threadgill, “Characterisation of recombinant human aldehyde dehydrogenase 10: Implications for Sj?gren-Larsson syndrome”, J. Enzy. Inhibit. Med. Chem., 2007, 22, 584-590. T. Searles, D. Butler, W. Chien, M. Mukherji, M. D. Lloyd and C. J. Schofield, “Studies on the specificity of unprocessed and mature forms of phytanoyl-CoA 2-hydroxylase and mutation of iron-binding residues”, J. Lipid Res., 2005, 46, 1660-1666. K. R. Acharya and M. D. Lloyd, “The advantages and limitations of protein crystal structures”, Trends in Pharmacological Sciences, 2005, 26, 10-14 (review). M. D. Lloyd, N. Thiyagarajan, Y. T. Ho, L. W. L. Woo, O. B. Sutcliffe, A. Purohit, M. J. Reed, K. R. Acharya, B. V. L. Potter, “First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors”, Biochemistry, 2005, 44, 6858-6866. M.D. Lloyd, R. L. Pedrick, R. Natesh, L. W. L. Woo, A. Purohit, M. J. Reed, K. R. Acharya and B. V. L. Potter, Crystal structure of human carbonic anhydrase II at 1.95 ? resolution in complex with 667-coumate, a novel anti-cancer agent”, Biochem. J., 2005, 385, 715-720. M. D. Lloyd, S. J. Lipscomb, K. S. Hewitson, C. M. H. Hensgens,, J. E. Baldwin, C. J. Schofield, “Controlling the substrate selectivity of deacetoxy/deacetylcephalosporin C synthase”, J. Biol. Chem., 2004, 279, 15420-15426.