Li, Wenhong - UT Southwestern Medical Center

个人简介

Education Undergraduate University of Science Technology - China Graduate School University of California-San Diego (1993) Graduate School University of California-San Diego (1996) Honors & Awards Junior Investigator Award American Cancer Society (2002) Career Development Award American Diabetes Association (2001) Martin D. Karmen Prize In recognition of the excellence of Ph.D. thesis, UCSD (1997) Jane Hart Memorial Award Department of Chemistry and Biochemistry, University of California, San Diego (1994)

研究领域

Research Interest Cell biology of diabetes and insulin release in islet beta cells Functional analysis of microRNAs Probe engineering and chemical biology

近期论文

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Jiahui Wu, Lin Liu, Tomoki Matsuda, Yongxin Zhao, Aleksander Rebane, Mikhail Drobizhev, Yu-Fen Chang, Satoko Araki, Yoshiyuki Arai, Kelsey March, Thomas E. Hughes, Ken Sagou, Takaki Miyata, Takeharu Nagai*, Wen-hong Li*, Robert E. Campbell*, Improved orange and red Ca2+ indicators and photophysical considerations for optogenetic applications, ACS Chemical Neuroscience, 2013 Mar 19. [Epub ahead of print] Wen-hong Li, Daliang Li Fluorescent probes for monitoring regulated secretion, Current Opinion in Chemical Biology, doi: 10.1016/j.cbpa.2013.04.026. [Epub ahead of print] Jennifer A. Schumacher, Shiuhwei Chen, Wen-Hong Li, Jennifer K. Pirri, Mark J. Alkema, Chieh Chang & Chiou-Fen Chuang, Intercellular calcium signaling in a gap junction-coupled cell network establishes asymmetric neuronal fates in C. elegans, Development, 2012, 139, 4191-4201. Wen-hong Li, Genhua Zheng, Photoactivatable fluorophores and techniques for biological imaging applications, Photochem Photobio Sci. 2012, 11, 460-471. Daliang Li, Shiuhwei Chen, Elisa A. Bellomo, Andrei I. Tarasov, Callan Kaut, Guy A. Rutter & Wen-hong Li, Imaging dynamic insulin release using a fluorescent zinc indicator for monitoring induced exocytotic release (ZIMIR). Proc Natl Acad Sci. 2011, 108, 21063-21068 Genhua Zheng, Luisa Cochella, Jie Liu, Oliver Hobert & Wen-hong Li, Temporal and spatial regulation of microRNA activity with photo-activatable cantimirs, ACS Chem Biol, 2011, DOI: 10.1021/cb200290e. Genhua Zheng, Victor Ambros, Wen-hong Li, Inhibiting miRNA in C. elegans using a potent and selective antisense reagent, Silence, 2010, 1:9 Genhua Zheng, Victor Ambros, Wen-hong Li, Fluorescently labeled antisense reagents for inhibiting miRNA in C. elegans, The Worm Breeder's Gazette 2009, 18:15. Wen-hong Li, Photo-activatable probes for the analysis of receptor function in living cells, Methods in Molecular Biology (Live Cell Imaging: Methods and Protocols), 591, 2009, 105 - 120. Zhuoru Wu, Kate Luby-Phelps, Abhijit Bugde, Laura A. Molyneux, Bray Denard, Wen-Hong Li, Qurol M. Suel & David L. Garbers, Capacity for stochastic self-renewal and differentiation in mammalian spermatogonial stem cells, J. Cell Biol., 2009, 187, 513-524. Xiaohu Ouyang, Ilya A. Shestopalov, Surajit Sinha, Genhua Zheng, Wen-Hong Li, Andrew J. Olsen & James K. Chen, Caged Morpholinos: Design, synthesis, and application, J. Am. Chem. Soc., 2009, 131, 13255 - 13269. Song Yang & Wen-hong Li, Assaying dynamic cell-cell junctional communication using noninvasive and quantitative fluorescence imaging techniques, LAMP and Infrared-LAMP, Nature Protocols, 2009, 4, 94-101. Yan-Ming Guo, Shiuhwei Chen, Premnath Shetty, Genhua Zheng, Rueyling Lin, Wen-hong Li, Imaging dynamic cell-cell junctional coupling in vivo using Trojan-LAMP. Nature Methods, 2008, 5, 835-841. Genghua Zheng, Yan-Ming Guo & Wen-hong Li, Photoactivatable and Water Soluble FRET Dyes with High Uncaging Cross Section. J. Am. Chem. Soc. 2007, 129, 10616-10617. René Bartz, Wen-Hong Li, Barney Venables, John K. Zehmer, Ruth Welti, Richard G. W. Anderson, Pingsheng Liu & Kent D. Chapman, Lipidomics reveals adiposomes store ether lipids and mediate phospholipid traffic, J. Lipid. Res. 2007, 48, 837 - 847. Kenneth Dakin & Wen-hong Li, Cell Membrane Permeable Esters of D-myo-Inositol 1,4,5-Trisphosphate Cell Calcium, 2007, 42, 291-301. Kenneth Dakin & Wen-hong Li, Infrared LAMP, two-photon uncaging and imaging of gap junctional communication in three dimensions, Nature Methods, 2006, 3, 959. Kenneth Dakin & Wen-Hong Li, Local Ca2+ rise near store operated Ca2+ channels inhibits cell coupling during capacitative Ca2+ influx in primary human fibroblasts, Cell Commun. Adhes. 2006, 13, 29-39. Quan Zheng, Houquan Dai, Matthew E. Merritt, Craig Malloy, CaiYuan Pan & Wen-Hong Li, A new class of macrocyclic lanthanide complexes for cell labeling and magnetic resonance imaging applications, J . Am. Chem. Soc., 2005, 127, 16178-16188. Guoxin Kang, Oleg G. Chepurny, Michael J Rindler, Leon Collis, Zina Chepurny, Wen-hong Li, Mark Harbeck, Michael W Roe & George G Holz, A cAMP and Ca2+ coincidence detector in support of Ca2+-induced Ca2+ release (CICR) in pancreatic beta cells, J. Physiology, 2005, 566, 173-188.