个人简介

郭文丽，1985年出生，河南新乡人。2015年毕业于中国科学院生态环境研究中心。 主持和参与课题 有机磷农药毒死蜱与镉引发肝细胞复合毒性效应的作用机制 21377159 国家基金委 面上项目 2014.01-2017.12 90 5 基于金属组学揭示纳米银肝细胞毒性的分子机制 21407169 国家基金委 青年基金 2015.01-2017.12 26 2 纳米银通过改变遗传信息稳定性影响 红系前体细胞分化成熟的机理研究 21407172 国家基金委 青年基金 2015.01-2017.12 28 2 稀土氧化物纳米材料对DNA甲基化和羟甲基化的调控机理及其毒性研究 21577165 国家基金委 面上项目 2016.01-2019.12 66 2 PCBs与镉复合暴露诱发鱼类肝脏毒性的机制初探 qd15189 河南师范大学博士启动 2016.01-2018.12 8 1 渔业养殖水质氨氮检测试剂的研制 1621022 10071 河南省科技厅 科技攻关 2016.01-2017.12 10 1

研究领域

1.环境污染物以及外源因子对鱼类的致毒效应及机理； 2.渔业养殖中快速检测产品的研发：通过酶免、胶体金等方法检测水质、疾病和农残药残。

主要从事环境污染与水生动物健康相关研究。

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Guo W, Zhang S, Chen Y, Zhang D, Yuan L, Cong H, et al. An important role of the hepcidin-ferroportin signaling in affecting tumor growth and metastasis. Acta biochimica et biophysica Sinica. 2015;47(9):703-15. 2. Guo W, Zhang S, Liu S. Establishment of a novel orthotopic model of breast cancer metastasis to the lung. Oncology reports. 2015;33(6):2992-8. 3. Guo W, Zhang J, Li W, Xu M, Liu S. Disruption of iron homeostasis and resultant health effects upon exposure to various environmental pollutants: A critical review. Journal of environmental sciences (China). 2015;34:155-64. 4. Sun L*, Guo W*, Yin C, Zhang S, Qu G, Hou Y, et al. Hepcidin deficiency undermines bone load-bearing capacity through inducing iron overload. Gene. 2014;543(1):161-5. (*co-first author) 5. He W, Guo W, Qian Y, Zhang S, Ren D, Liu S. Synergistic hepatotoxicity by cadmium and chlorpyrifos: disordered hepatic lipid homeostasis. Molecular medicine reports. 2015;12(1):303-8. 6. Qian, Y.; Zhang, S.; Guo, W.; Ma, J.; Chen, Y.; Wang, L.; Zhao, M.; Liu, S. Polychlorinated biphenyls (PCBs) inhibit hepcidin expression through an estrogen-like effect associated with disordered systemic iron homeostasis. Chemical research in toxicology 2015, 28, 629-40. 7. Zhang S, Chen Y, Guo W, Yuan L, Zhang D, Xu Y, et al. Disordered hepcidin-ferroportin signaling promotes breast cancer growth. Cellular signalling. 2014;26(11):2539-50. 8. Zhang, M.; Liu, J.; Guo, W.; Liu, X.; Liu, S.; Yin, H. Icariin regulates systemic iron metabolism by increasing hepatic hepcidin expression through Stat3 and Smad1/5/8 signaling. International journal of molecular medicine 2016, 37, 1379-88. 9. Sun, L.; Zhang, S.; Guo, W.; He, W.; Qian, Y.; Qu, G.; Ji, H.; Rong, H.; Liu, S. Sublethal exposure of organophosphate pesticide chlorpyrifos alters cellular iron metabolism in hepatocytes and macrophages. International journal of molecular medicine 2014, 34, 1395-400. 10. Chen, Y.; Zhang, S.; Wang, X.; Guo, W.; Wang, L.; Zhang, D.; Yuan, L.; Zhang, Z.; Xu, Y.; Liu, S. Disordered signaling governing ferroportin transcription favors breast cancer growth. Cellular signalling 2015, 27, 168-76. 11. Sun, L.; Wang, L.; Wang, Z.; He, W.; Zhang, S.; Guo, W.; Qian, Y.; Ji, H.; Rong, H.; Liu, S. Cadmium depletes cellular iron availability through enhancing ferroportin translation via iron responsive element. Molecular medicine reports 2015, 11, 3129-33.