Whitley, Paul - University of Bath - Department of Biology & Biochemistry

个人简介

PhD University of Edinburgh, 1991 Postdoctoral work at Stockholm University and Karolinska Institute, Sweden, 1991-1999 At University of Bath since January 1999 Lecturer in Cell Biology since September 2000 Senior lecturer since September 2011

研究领域

My lab is interested in endosomal sorting machineries and the cellular processes in which they are involved. Many eukaryotic cell surface proteins (such as growth factor receptors) are selectively removed from the plasma membrane by endocytosis and then either sorted into late endosomes/multivesicular bodies (MVBs) for degradation or recycled back to the plasma membrane. The fate of endocytic cargoes has implications for cell programming and can influence cellular processes such as the cell cycle, apoptosis, migration and cell fate determination. Defects in endocytic sorting have been linked to a variety of human diseases such as cancer and neurodegeneration.

近期论文

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Gulsen, T., Hadjicosti, I., Li, Y., Zhang, X., Whitley, P. R. and Chalmers, A. D., 2016. Truncated RASSF7 promotes centrosomal defects and cell death. Developmental Biology, 409 (2), pp. 502-517. Helsby, M. A., Leader, P. M., Fenn, J. R., Gulsen, T., Bryant, C., Doughton, G., Sharpe, B., Whitley, P., Caunt, C. J., James, K., Pope, A. D., Kelly, D. H. and Chalmers, A. D., 2014. CiteAb:A searchable antibody database that ranks antibodies by the number of times they have been cited. BMC Cell Biology, 15 (1), 6. Koumanov, F., Pereira, V. J., Whitley, P. R. and Holman, G. D., 2012. GLUT4 Traffic through an ESCRT-III-Dependent Sorting Compartment in Adipocytes. PLoS ONE, 7 (9), e44141. Dukes, J. D., Whitley, P. and Chalmers, A. D., 2012. The PIKfyve inhibitor YM201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells. PLoS ONE, 7 (3), e28659. Chalmers, A. and Whitley, P., 2012. Continuous endocytic recycling of tight junction proteins: how and why? Essays in Biochemistry, 53, pp. 41-54. Dukes, J. D., Whitley, P. and Chalmers, A. D., 2011. The MDCK variety pack: choosing the right strain. BMC Cell Biology, 12, 43. Dukes, J. D., Fish, L., Richardson, J. D., Blaikley, E., Burns, S., Caunt, C. J., Chalmers, A. D. and Whitley, P., 2011. Functional ESCRT machinery is required for constitutive recycling of claudin-1 and maintenance of polarity in vertebrate epithelial cells. Molecular Biology of the Cell, 22 (17), pp. 3192-3205. Whitley, P., Hinz, S. and Doughty, J., 2009. Arabidopsis FAB1/PIKfyve proteins are essential for development of viable pollen. Plant Physiology, 151 (4), pp. 1812-1822. Bangs, F., Yin, Y., Paton, R., Prescott, A., James, J., Davey, M., Whitley, P., Genikhovich, G., Technau, U. and Briscoe, J., 2009. The developmental mutant talpid3 lacks primary cilia. Mechanisms of Development, 126, S262. Yin, Y., Bangs, F., Paton, I. R., Prescott, A., James, J., Davey, M. G., Whitley, P., Genikhovich, G., Technau, U., Burt, D. W. and Tickle, C., 2009. The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation. Development, 136 (4), pp. 655-664. Dukes, J. D., Richardson, J. D., Simmons, R. and Whitley, P., 2008. A dominant-negative ESCRT-III protein perturbs cytokinesis and trafficking to lysosomes. Biochemical Journal, 411 (2), pp. 233-239.