Urrutia, Araxi - University of Bath - Department of Biology & Biochemistry

研究领域

I’m interested in the evolution of genes and genomes and how it impacts on the evolution of phenotypes. My research projects relate to the study of gene transcription changes during evolution and disease states and the evolution of gene and genome’s sequence, structure and organisation.

近期论文

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Monzón Sandoval, J., Castillo Morales, A., Urrutia, A. and Gutierrez, H., 2016. Modular reorganization of the global network of gene regulatory interactions during perinatal human brain development. BMC Developmental Biology, 16, 13. Ockendon, N. F., O'Connell, L. A., Bush, S. J., Monzón Sandoval, J., Barnes, H., Szekely, T., Hofmann, H. A., Dorus, S. and Urrutia, A. O., 2016. Optimization of next-generation sequencing transcriptome annotation for species lacking sequenced genomes. Molecular Ecology Resources, 16 (2), pp. 446-458. Tovar-Corona, J. M., Castillo-Morales, A., Chen, L., Olds, B. P., Clark, J. M., Reynolds, S. E., Pittendrigh, B. R., Feil, E. J. and Urrutia, A. O., 2015. Alternative splice in alternative lice. Molecular Biology and Evolution, 32 (10), pp. 2749-2759. Bush, S. J., Kover, P. X. and Urrutia, A. O., 2015. Lineage-specific sequence evolution and exon edge conservation partially explain the relationship between evolutionary rate and expression level in A. thaliana. Molecular Ecology, 24 (12), pp. 3093-3106. Porazinski, S., Wang, H., Asaoka, Y., Behrndt, M., Miyamoto, T., Morita, H., Hata, S., Sasaki, T., Krens, S. F. G., Osada, Y., Asaka, S., Momoi, A., Linton, S., Miesfeld, J. B., Link, B. A., Senga, T., Castillo-Morales, A., Urrutia, A. O., Shimizu, N., Nagase, H., Matsuura, S., Bagby, S., Kondoh, H., Nishina, H., Heisenberg, C. P. and Furutani-Seiki, M., 2015. YAP is essential for tissue tension to ensure vertebrate 3D body shape. Nature, 521 (7551), pp. 217-221. Chen, L., Bush, S.J., Tovar-Corona, J.M., Castillo Morales, A. and Urrutia, A.O., 2014. Correcting for differential transcript coverage reveals a strong relationship between alternative splicing and organism complexity. Molecular Biology and Evolution, 31 (6), pp. 1402-1413. Bush, S. J., Castillo Morales, A., Tovar-Corona, J. M., Chen, L., Kover, P. X. and Urrutia, A. O., 2014. Presence-absence variation in A. thaliana is primarily associated with genomic signatures consistent with relaxed selective constraints. Molecular Biology and Evolution, 31 (1), pp. 59-69. Zhang, Y., Castillo Morales, A., Jiang, M., Zhu, Y., Hu, L., Urrutia, A. O., Kong, X. and Hurst, L. D., 2013. Genes that escape X-inactivation in humans have high intraspecific variability in expression, are associated with mental impairment but are not slow evolving. Molecular Biology and Evolution, 30 (12), pp. 2588-2601. Castillo Morales, A., Monzón Sandoval, J., Urrutia, A. O. and Gutierrez, H., 2013. Increased brain size in mammals is associated with size variations in gene families with cell signalling, chemotaxis and immune-related functions. Proceedings of the Royal Society B: Biological Sciences, 281 (1775), p. 20132428. Wu, X., Tronholm, A., Fernandez Cáceres, E., Tovar-Corona, J. M., Chen, L., Urrutia, A.O. and Hurst, L.D., 2013. Evidence for deep phylogenetic conservation of exonic splice-related constraints:Splice-related skews at exonic ends in the brown alga Ectocarpus are common and resemble those seen in humans. Genome Biology and Evolution, 5 (9), pp. 1731-1745. Chen, L., Tovar-Corona, J. M. and Urrutia, A. O., 2012. Alternative splicing:Α potential source of functional innovation in the eukaryotic genome. International Journal of Evolutionary Biology, 2012, 596274. Gutierrez, H., Castillo Morales, A., Monzon, J. and Urrutia, A. O., 2011. Protein amino acid composition: a genomic signature of encephalization in mammals. PLoS ONE, 6 (11), e27261. Chen, L., Tovar-Corona, J. M. and Urrutia, A. O., 2011. Increased levels of noisy splicing in cancers, but not for oncogene-derived transcripts. Human Molecular Genetics, 20 (22), pp. 4422-4429. Urrutia, A. and Urrutia Fucugauchi, J., 2011. Poblamiento temprano de America. In: Quaternario. National University of Mexico, UNAM. Urrutia, A. O., Ocana, L. B. and Hurst, L. D., 2008. Do Alu repeats drive the evolution of the primate transcriptome? Genome Biology, 9 (2), R25.